<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml">With the increasing use of landfill sites, leachates produced by uncontrolled waste disposal have became a serious threat for the aquatic environment. The aim of this study was to evaluate the genotoxicity of leachate and of well water sampled close to the town of Settat in Morocco using the micronucleus test and proliferation kinetics of human peripheral blood lymphocytes <italic>in vitro.</italic> We also analysed a number of physical and chemical parameters, including pH, % O2, chemical oxygen demand (COD), HCO3-, Ca2+, Mg2+, Cl-, and conductivity.The analysis showed much higher levels of nearly all parameters than the Moroccan standard. Increased micronucleus frequencies were also found for both leachate and well water. Preliminary results indicate that both types of water are genotoxic and pose environmental and human health risk.</abstract>

With the increasing use of landfill sites, leachates produced by uncontrolled waste disposal have became a serious threat for the aquatic environment. The aim of this study was to evaluate the genotoxicity of leachate and of well water sampled close to the town of Settat in Morocco using the micronucleus test and proliferation kinetics of human peripheral blood lymphocytes in vitro. We also analysed a number of physical and chemical parameters, including pH, % O2, chemical oxygen demand (COD), HCO3-, Ca2+, Mg2+, Cl-, and conductivity.The analysis showed much higher levels of nearly all parameters than the Moroccan standard. Increased micronucleus frequencies were also found for both leachate and well water. Preliminary results indicate that both types of water are genotoxic and pose environmental and human health risk.

<italic>In Vitro</italic> Genotoxicity of Settat Town Landfill Leachate, Morocco

Agrofood and Health Laboratory, Faculty of Science and Technology, University Hassan I, Settat, Morocco

Laboratory of Toxicology, Scientific Institute of Public Health, Brussels, Belgium

Archives of Industrial Hygiene and Toxicology

 Genotoxicity of Settat Town Landfill Leachate, Morocco

With the increasing use of landfill sites, leachates produced by uncontrolled waste disposal have became a serious threat for the aquatic environment. The aim...

In Vitro Genotoxicity of Settat Town Landfill Leachate, Morocco

Publicado en línea: 06 jul 2009

Páginas: 179 - 184

DOI: https://doi.org/10.2478/10004-1254-60-2009-1925

Palabras clave
dose-effect, lymphocyte, micronucleus, physico-chemical properties, proliferation index, toxicity

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