Effects of methylphenidate on height, weight and blood biochemistry parameters in prepubertal boys with attention deficit hyperactivity disorder: an open label prospective study
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De Sousa A, Kalra G. Drug therapy of attention deficit hyperactivity disorder: current trends. Mens Sana Monogr 2012;10(1):45-69.De SousaAKalraG. Drug therapy of attention deficit hyperactivity disorder: current trends. 2012;10(1):45-69.Search in Google Scholar
Thomas R, Sanders S, Doust J, Beller E, Glasziou P. Prevalence of attention-deficit/hyperactivity disorder: a systematic review and meta-analysis. Pediatrics 2015;135(4):e994-e1001.ThomasRSandersSDoustJBellerEGlasziouP. Prevalence of attention-deficit/hyperactivity disorder: a systematic review and meta-analysis. 2015;135(4):e994-e1001.Search in Google Scholar
Slobodin O, Davidovitch M. Gender differences in objective and subjective measures of ADHD among clinic-referred children. Front Hum Neurosci 2019;13:441.SlobodinODavidovitchM. Gender differences in objective and subjective measures of ADHD among clinic-referred children. 2019;13:441.Search in Google Scholar
Hodgkins P, Shaw M, Coghill D, Hechtman L. Amfetamine and methylphenidate medications for attention-deficit/hyperactivity disorder: complementary treatment options. Eur Child Adolesc Psychiatry 2012;21 (9):477-92.HodgkinsPShawMCoghillDHechtmanL. Amfetamine and methylphenidate medications for attention-deficit/hyperactivity disorder: complementary treatment options. 2012;21 (9):477-92.Search in Google Scholar
Cortese S, Adamo N, Del Giovane C, Mohr-Jensen C, Hayes AJ, Carucci S et al. Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis. Lancet Psychiatry 2018;5(9):727-38.CorteseSAdamoNDel GiovaneCMohr-JensenCHayesAJCarucciS. Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis. 2018;5(9):727-38.Search in Google Scholar
Wilens TE. Effects of methylphenidate on the catecholaminergic system in attention-deficit/hyperactivity disorder. J Clin Psychopharmacol. 2008;28(3 Suppl 2):s46-53.WilensTE. Effects of methylphenidate on the catecholaminergic system in attention-deficit/hyperactivity disorder. . 2008;28(3Suppl 2):s46-53.Search in Google Scholar
Faraone SV. The pharmacology of amphetamine and methylphenidate: relevance to the neurobiology of attention-deficit/hyperactivity disorder and other psychiatric comorbidities. Neurosci Biobehav Rev 2018;87:255-70.FaraoneSV. The pharmacology of amphetamine and methylphenidate: relevance to the neurobiology of attention-deficit/hyperactivity disorder and other psychiatric comorbidities. 2018;87:255-70.Search in Google Scholar
Ptacek R, Kuzelova H. Methylphenidate and growth in ADHD children. Act Nerv Super Rediviv. 2011;53(2):45-8. Available from http://www.rediviva.sav.sk/53i2/45.pdf. Date of access: October 6, 2020PtacekRKuzelovaH. Methylphenidate and growth in ADHD children. . 2011;53(2):45-8. Available from http://www.rediviva.sav.sk/53i2/45.pdf. Date of access: October 6, 2020Search in Google Scholar
Satterfield JH, Cantwell DP, Schell A., Blaschke T. Growth of hyperactive children treated with methylphenidate. Arch Gen Psychiatry 1979;36(2):212-7.SatterfieldJHCantwellDPSchellA.BlaschkeT. Growth of hyperactive children treated with methylphenidate. 1979;36(2):212-7.Search in Google Scholar
Dura-Trave T, Yoldi-Petri ME, Gallinas-Victoriano F, Zardoya-Santos P. Effects of osmotic-release methylphenidate on height and weight in children with attention-deficithyperactivitydisorder (ADHD) following up to four years of treatment. J Child Neurol 2012;27(5):604-9.Dura-TraveTYoldi-PetriMEGallinas-VictorianoFZardoya-SantosP. Effects of osmotic-release methylphenidate on height and weight in children with attention-deficithyperactivitydisorder (ADHD) following up to four years of treatment. 2012;27(5):604-9.Search in Google Scholar
Faraone SV, Biederman J, Morley CP, Spencer TJ. Effect of stimulants on height and weight: a review of the literature. J Am Acad Child Adolesc Psychiatry 2008;47(9):994-1009.FaraoneSVBiedermanJMorleyCPSpencerTJ. Effect of stimulants on height and weight: a review of the literature. 2008;47(9):994-1009.Search in Google Scholar
Kim HW, Kim SO, Shon S, Lee JS, Lee HJ, Choi JH. Effect of methylphenidate on height and weight in Korean children and adolescents with attention deficit hyperactivity disorder: a retrospective chart review. J Child Adolesc Psychopharmacol 2014;24(8):448-53.KimHWKimSOShonSLeeJSLeeHJChoiJH. Effect of methylphenidate on height and weight in Korean children and adolescents with attention deficit hyperactivity disorder: a retrospective chart review. 2014;24(8):448-53.Search in Google Scholar
Schachar RJ, Cunningham C, Corkum PV. Behavioral, situational and temporal effects of treatment of ADHD with methylphenidate. J Am Acad Child Adolesc Psychiatry 1997;36(6):754-63.SchacharRJCunninghamCCorkumPV. Behavioral, situational and temporal effects of treatment of ADHD with methylphenidate. 1997;36(6):754-63.Search in Google Scholar
Gurbuz F, Gurbuz BB, Celik GG, Yildirim V, Ucakturk SA, Seydaoglu G, et al. Effects of methylphenidate on appetite and growth in children diagnosed with attention deficit and hyperactivity disorder. J Pediatr Endocrinol Metab 2016;29(1):85-92.GurbuzFGurbuzBBCelikGGYildirimVUcakturkSASeydaogluG, . Effects of methylphenidate on appetite and growth in children diagnosed with attention deficit and hyperactivity disorder. 2016;29(1):85-92.Search in Google Scholar
Charach A, Figueroa M, Chen S, Ickowicz A, Schachar R. Stimulant treatment over 5 years: effects on growth. J Am Acad Child Adolesc Psychiatry 2006;45(4):415-21.CharachAFigueroaMChenSIckowiczASchacharR. Stimulant treatment over 5 years: effects on growth. 2006;45(4):415-21.Search in Google Scholar
Díez-Suárez A, Vallejo-Valdivielso M, Marín-Méndez JJ, deCastro-Manglano P, Soutullo CA. Weight, height, and body mass index in patients with attention-deficit/hyperactivity disorder treated with methylphenidate. J Child Adolesc Psychopharmacol 2017;27(8):723-30.Díez-SuárezAVallejo-ValdivielsoMMarín-MéndezJJdeCastro-ManglanoPSoutulloCA. Weight, height, and body mass index in patients with attention-deficit/hyperactivity disorder treated with methylphenidate. 2017;27(8):723-30.Search in Google Scholar
Turan S, Akay A. The effects of methylphenidate on weight, height, and body mass index in Turkish children and adolescents with ADHD. Alpha Psychiatry 2020;21(2):211-7.TuranSAkayA. The effects of methylphenidate on weight, height, and body mass index in Turkish children and adolescents with ADHD. 2020;21(2):211-7.Search in Google Scholar
Koonrungsesomboon K, Koonrungsesomboon N. The effects of methylphenidate treatment on child growth in Thai children and adolescents with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol 2020;30(3):189-97.KoonrungsesomboonKKoonrungsesomboonN. The effects of methylphenidate treatment on child growth in Thai children and adolescents with attention-deficit/hyperactivity disorder. 2020;30(3):189-97.Search in Google Scholar
Zhang H, Du M, Zhuang S. Impact of long-term treatment of methylphenidate on height and weight of school age children with ADHD. Neuropediatrics 2010;41 (2):55-9.ZhangHDuMZhuangS. Impact of long-term treatment of methylphenidate on height and weight of school age children with ADHD. 2010;41 (2):55-9.Search in Google Scholar
Moungnoi P, Maipang P. Long-term effects of short-acting methylphenidate on growth rates of children with attention deficit hyperactivity disorder at Queen Sirikit, National Institute of Child Health. J Med Assoc Thai 2011;94(Suppl 3):S158-63.MoungnoiPMaipangP. Long-term effects of short-acting methylphenidate on growth rates of children with attention deficit hyperactivity disorder at Queen Sirikit, National Institute of Child Health. 2011;94(Suppl 3):S158-63.Search in Google Scholar
Lisska MC, Rivkees SA. Daily methylphenidate use slows the growth of children: a community based study. J Pediatr Endocrinol Metab 2003;16(5):711-8.LisskaMCRivkeesSA. Daily methylphenidate use slows the growth of children: a community based study. 2003;16(5):711-8.Search in Google Scholar
Harstad EB, Weaver AL, Katusic SK, Colligan RC, Kumar S, Chan E, et al. ADHD, stimulant treatment, and growth: a longitudinal study. Pediatrics 2014;134(4):e935-44.HarstadEBWeaverALKatusicSKColliganRCKumarSChanE, . ADHD, stimulant treatment, and growth: a longitudinal study. 2014;134(4):e935-44.Search in Google Scholar
Greenhill LL, Swanson JM, Hechtman L, Waxmonsky J, Arnold LE, Molina BSG, et al. Trajectories of growth associated with long-term stimulant medication in the multimodal treatment study of attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 2020;59(8):978-89.GreenhillLLSwansonJMHechtmanLWaxmonskyJArnoldLEMolinaBSG, . Trajectories of growth associated with long-term stimulant medication in the multimodal treatment study of attention-deficit/hyperactivity disorder. 2020;59(8):978-89.Search in Google Scholar
Swanson JM, Arnold LE, Molina BSG, Sibley MH, Hechtman LT, Hinshaw SP, et al. Young adult outcomes in the follow-up of the multimodal treatment study of attention-deficit/hyperactivity disorder: symptom persistence, source discrepancy, and height suppression. J Child Psychol Psychiatry 2017;58(6):663-78.SwansonJMArnoldLEMolinaBSGSibleyMHHechtmanLTHinshawSP, . Young adult outcomes in the follow-up of the multimodal treatment study of attention-deficit/hyperactivity disorder: symptom persistence, source discrepancy, and height suppression. 2017;58(6):663-78.Search in Google Scholar
Zeiner P. Body growth and cardiovascular function after extended treatment (1.75 years) with methylphenidate in boys with attention-deficit hyperactivity disorder. J Child Adolesc Psychopharmacol 1995 5 (2):129-38.ZeinerP. Body growth and cardiovascular function after extended treatment (1.75 years) with methylphenidate in boys with attention-deficit hyperactivity disorder. 19955 (2):129-38.Search in Google Scholar
Bereket A, Turan S, Karaman MG, Haklar G, Ozbay F, Yazgan MY. Height, weight, IGF-I, IGFBP-3 and thyroid functions in prepubertal children with attention deficit hyperactivity disorder: effect of methylphenidate treatment. Horm Res 2005;63(4):159-64.BereketATuranSKaramanMGHaklarGOzbayFYazganMY. Height, weight, IGF-I, IGFBP-3 and thyroid functions in prepubertal children with attention deficit hyperactivity disorder: effect of methylphenidate treatment. 2005;63(4):159-64.Search in Google Scholar
Kang KD, Yun SW, Chung U, Kim TH, Park JH, Park IH, et al. Effects of methylphenidate on body index and physical fitness in Korean children with attention deficit hyperactivity disorder. Hum Psychopharmacol 2016;31(2):76-82.KangKDYunSWChungUKimTHParkJHParkIH, . Effects of methylphenidate on body index and physical fitness in Korean children with attention deficit hyperactivity disorder. 2016;31(2):76-82.Search in Google Scholar
Lahat E, Weiss M, Ben-Shlomo A, Evans S, Bistritzer T. Bone mineral density and turnover in children with attention-deficit hyperactivity disorder receiving methylphenidate. J Child Neurology 2000;15(7):436-9.LahatEWeissMBen-ShlomoAEvansSBistritzerT. Bone mineral density and turnover in children with attention-deficit hyperactivity disorder receiving methylphenidate. 2000;15(7):436-9.Search in Google Scholar
Poulton A, Briody J, McCorquodale T, Melzer E, Herrmann M, Baur LA, et al. Weight loss on stimulant medication: how does it affect body composition and bone metabolism? – A prospective longitudinal study. Int J Pediatr Endocrinol 2012;2012(1):30.PoultonABriodyJMcCorquodaleTMelzerEHerrmannMBaurLA, . Weight loss on stimulant medication: how does it affect body composition and bone metabolism? – A prospective longitudinal study. 2012;2012(1):30.Search in Google Scholar
Poulton AS, Bui Q, Melzer E, Evans R. Stimulant medication effects on growth and bone age in children with attention-deficit/hyperactivity disorder: a prospective cohort study. Int Clinical Psychopharmacol 2016:31(2):93–9.PoultonASBuiQMelzerEEvansR. Stimulant medication effects on growth and bone age in children with attention-deficit/hyperactivity disorder: a prospective cohort study. 2016:31(2):93–9.Search in Google Scholar
Feuer AJ, Thai A, Demmer RT, Vogiatzi M. Association of stimulant medication use with bone mass in children and adolescents with attention-deficit/hyperactivity disorder. JAMA Pediatr 2016:170(12):e162804.FeuerAJThaiADemmerRTVogiatziM. Association of stimulant medication use with bone mass in children and adolescents with attention-deficit/hyperactivity disorder. 2016:170(12):e162804.Search in Google Scholar
Kim WJ, Bang YR, Kang JW, Yoo JH, Kim SH, Park JH. Preliminary investigation of association between methylphenidate and serum growth markers in children with attention-deficit/hyperactivity disorder: a cross-sectional case-control study. Soa Chongsonyon Chongsin Uihak 2020;31(3):154–60.KimWJBangYRKangJWYooJHKimSHParkJH. Preliminary investigation of association between methylphenidate and serum growth markers in children with attention-deficit/hyperactivity disorder: a cross-sectional case-control study. 2020;31(3):154–60.Search in Google Scholar
Goldman RD. ADHD stimulants and their effect on height in children. Can Fam Physician 2010;56(2):145-6.GoldmanRD. ADHD stimulants and their effect on height in children. 2010;56(2):145-6.Search in Google Scholar
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders: Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. Arlington, VA. American Psychiatric Association, 2013.American Psychiatric Association. , Fifth Edition. Arlington, VA. American Psychiatric Association, 2013.Search in Google Scholar
Pelham WE, Gnagy EM, Burrows-Maclean L, Williams A, Fabiano GA, Morrisey SM, et al. Once-a-day concerta methylphenidate versus three-times-daily methylphenidate in laboratory and natural settings. Pediatrics 2001;107(6):e105.PelhamWEGnagyEMBurrows-MacleanLWilliamsAFabianoGAMorriseySM. Once-a-day concerta methylphenidate versus three-times-daily methylphenidate in laboratory and natural settings. 2001;107(6):e105.Search in Google Scholar
ceddcozum.com. Istanbul, Turkey: Turkish Pediatric Endocrinology and Diabetes Society; c2017-06-1 [updated 2020 June 3; cited 2021 Jan 29]. Available from: https://www.ceddcozum.com. Istanbul, Turkey: Turkish Pediatric Endocrinology and Diabetes Society; c2017-06-1 [updated 2020 June 3; cited 2021 Jan 29]. Available from: https://www.ceddcozum.comSearch in Google Scholar
Demir K, Özen S, Konakçı E, Aydın M, Darendeliler F. A comprehensive online calculator for pediatric endocrinologists: ÇEDD çözüm/TPEDS Metrics. J Clin Res Pediatr Endocrinol 2017:9(2):182–4.DemirKÖzenSKonakçıEAydınMDarendelilerF. A comprehensive online calculator for pediatric endocrinologists: ÇEDD çözüm/TPEDS Metrics. 2017:9(2):182–4.Search in Google Scholar
Neyzi O, Bundak R, Gökçay G, Günöz H, Furman A, Darendeliler F, et al. Reference values for weight, height, head circumference, and body mass index in Turkish children. J Clin Res Pediatric Endocrinol 2015;7(4):280–93.NeyziOBundakRGökçayGGünözHFurmanADarendelilerF. Reference values for weight, height, head circumference, and body mass index in Turkish children. 2015;7(4):280–93.Search in Google Scholar
Spencer TJ, Faraone SV, Biederman J, Lerner M, Cooper KM, Zimmerman B, et al. Does prolonged therapy with a long-acting stimulant suppress growth in children with ADHD?. J Am Acad Child Adolesc Psychiatry 2006;45:527–37.SpencerTJFaraoneSVBiedermanJLernerMCooperKMZimmermanB. Does prolonged therapy with a long-acting stimulant suppress growth in children with ADHD?. 2006;45:527–37.Search in Google Scholar
Bou Khalil R, Fares N, Saliba Y, Tamraz J, Richa S. L’effet de la méthylphénidate sur l’appétit et le poids [The effect of methylphenidate on appetite and weight]. Encephale 2017;43(6):577–81.Bou KhalilRFaresNSalibaYTamrazJRichaS. L’effet de la méthylphénidate sur l’appétit et le poids [The effect of methylphenidate on appetite and weight]. 2017;43(6):577–81.Search in Google Scholar
Poulton A. Growth on stimulant medication; clarifying the confusion: a review, Archives of Disease in Childhood. 2005;90:801–806. https://doi.org/10.1136/adc.2004.056952PoultonA. . 2005;90:801–806. https://doi.org/10.1136/adc.2004.056952Search in Google Scholar
Faraone SV, Lecendreux M, Konofal E. Growth dysregulation and ADHD: an epidemiologic study of children in France. J Atten Disord 2012;16 (7): 572–8.FaraoneSVLecendreuxMKonofalE. Growth dysregulation and ADHD: an epidemiologic study of children in France. 2012;16 (7): 572–8.Search in Google Scholar
Hanć T, Cieślik J. Growth in stimulant-naive children with attention-deficit/hyperactivity disorder using cross-sectional and longitudinal approaches. Pediatrics 2008;121(4):e967–74.HanćTCieślikJ. Growth in stimulant-naive children with attention-deficit/hyperactivity disorder using cross-sectional and longitudinal approaches. 2008;121(4):e967–74.Search in Google Scholar
Wigal SB, Wilens TE, Wolraich M, Lerner M. Hematologic and blood biochemistry monitoring during methylphenidate treatment in children with attention-deficit/hyperactivity disorder: 2-year, open-label study results. Pediatrics 2007;120(1):e120–8.WigalSBWilensTEWolraichMLernerM. Hematologic and blood biochemistry monitoring during methylphenidate treatment in children with attention-deficit/hyperactivity disorder: 2-year, open-label study results. 2007;120(1):e120–8.Search in Google Scholar
Charach G, Karniel E, Grosskopf I, Rabinovich A, Charach L. Methylphenidate has mild hyperglycemic and hypokalemia effects and increases leukocyte and neutrophil counts. Medicine (Baltimore) 2020;99(27):e20931.CharachGKarnielEGrosskopfIRabinovichACharachL. Methylphenidate has mild hyperglycemic and hypokalemia effects and increases leukocyte and neutrophil counts. 2020;99(27):e20931.Search in Google Scholar
Ilgin N, Senol S, Gucuyener K, Gokcora N, Sener S. Is increased D2 receptor availability associated with response to stimulant medication in ADHD. Dev Med Child Neurol 2001;43(11):755–60.IlginNSenolSGucuyenerKGokcoraNSenerS. Is increased D2 receptor availability associated with response to stimulant medication in ADHD. 2001;43(11):755–60.Search in Google Scholar
García-Tornadú I, Ornstein AM, Chamson-Reig A, Wheeler MB, Hill DJ, Arany E, et al. Disruption of the dopamine d2 receptor impairs insulin secretion and causes glucose intolerance. Endocrinology 2010;151(4): 1441–50.García-TornadúIOrnsteinAMChamson-ReigAWheelerMBHillDJAranyE. Disruption of the dopamine d2 receptor impairs insulin secretion and causes glucose intolerance. 2010;151(4): 1441–50.Search in Google Scholar
Shankar E, Santhosh KT, Paulose CS. Dopaminergic regulation of glucose-induced insulin secretion through dopamine D2 receptors in the pancreatic islets in vitro. IUBMB Life 2006;58(3):157–63.ShankarESanthoshKTPauloseCS. Dopaminergic regulation of glucose-induced insulin secretion through dopamine D2 receptors in the pancreatic islets in vitro. 2006;58(3):157–63.Search in Google Scholar
Bilinski WJ, Paradowski PT, Sypniewska G. Bone health and hyperglycemia in pediatric populations. Crit Rev Clin Lab Sci 2020;57(7):444–57.BilinskiWJParadowskiPTSypniewskaG. Bone health and hyperglycemia in pediatric populations. 2020;57(7):444–57.Search in Google Scholar
Pollock NK, Bernard PJ, Gower BA, Gundberg CM, Wenger K, Misra S, et al. Lower uncarboxylated osteocalcin concentrations in children with prediabetes is associated with beta-cell function. J Clin Endocrinol Metab 2011;96(7):e1092–9.PollockNKBernardPJGowerBAGundbergCMWengerKMisraS. Lower uncarboxylated osteocalcin concentrations in children with prediabetes is associated with beta-cell function. 2011;96(7):e1092–9.Search in Google Scholar
Giudici KV, Kindler JM, Martin BR, Laing EM, McCabe GP, McCabe LD, et al. Associations among osteocalcin, leptin and metabolic health in children ages 9-13 years in the United States. Nutr Metab (Lond) 2017;14:25.GiudiciKVKindlerJMMartinBRLaingEMMcCabeGPMcCabeLD. Associations among osteocalcin, leptin and metabolic health in children ages 9-13 years in the United States. 2017;14:25.Search in Google Scholar
Seibel MJ. Biochemical markers of bone turnover: part I: biochemistry and variability. Clin Biochem Rev 2005;26(4):97–122.SeibelMJ. Biochemical markers of bone turnover: part I: biochemistry and variability. 2005;26(4):97–122.Search in Google Scholar
Cashman KD. Vitamin D in childhood and adolescence. Postgrad Medical J 2007;83(978):230–5.CashmanKD. Vitamin D in childhood and adolescence. 2007;83(978):230–5.Search in Google Scholar
Khoshbakht Y, Bidaki R, Salehi-Abargouei A. Vitamin D status and attention deficit hyperactivity disorder. a systematic review and meta-analysis of observational studies. Adv Nutr 2018;9(1):9–20.KhoshbakhtYBidakiRSalehi-AbargoueiA. Vitamin D status and attention deficit hyperactivity disorder. a systematic review and meta-analysis of observational studies. 2018;9(1):9–20.Search in Google Scholar
Allen PJ. Creatine metabolism and psychiatric disorders: Does creatine supplementation have therapeutic value?. Neurosci Biobehav Rev 2012;36(5):1442–62.AllenPJ. Creatine metabolism and psychiatric disorders: Does creatine supplementation have therapeutic value?. 2012;36(5):1442–62.Search in Google Scholar
Ozer MK. Constitution of reference intervals of biochemical tests in pediatrics in İstanbul Medical Faculty, İstanbul University [dissertation in medicine on the Internet]. İstanbul University School Of Medicine Clinical Biochemistry Department. 2013. Available from https://tez.yok.gov.tr/UlusalTezMerkezi/tezSorguSonucYeni.jsp. Date of access: October 6, 2020OzerMK. . İstanbul University School Of Medicine Clinical Biochemistry Department. 2013. Available from https://tez.yok.gov.tr/UlusalTezMerkezi/tezSorguSonucYeni.jsp. Date of access: October 6, 2020Search in Google Scholar
Ng KW. Regulation of glucose metabolism and the skeleton. Clin Endocrinol (Oxf) 2011;75(2):147–55.NgKW. Regulation of glucose metabolism and the skeleton. 2011;75(2):147–55.Search in Google Scholar
Eapen E, Grey V, Don-Wauchope A, Atkinson SA. Bone health in childhood: usefulness of biochemical biomarkers. EJIFCC 2008;19(2):123–36.EapenEGreyVDon-WauchopeAAtkinsonSA. Bone health in childhood: usefulness of biochemical biomarkers. 2008;19(2):123–36.Search in Google Scholar