Selected classical and novel antiepileptic drugs – mechanisms of action, neuroprotection, and effectiveness in epileptic and non-epileptic conditions

Bialer M., Johannessen S.I., Kupferberg H.J., Levy R.H., Perucca E., Tomson T.:Progress report on new antiepileptic drugs: a summary of the Seventh Eilat Conference (EILAT VII). Epilepsy Res., 2004, 61: 1–48.10.1016/j.eplepsyres.2004.07.010Search in Google Scholar

Biton V., Bourgeois B.F.:Topiramate in patients with juvenile myoclonic epilepsy. Arch. Neurol., 2005, 11: 1705–1708.10.1001/archneur.62.11.1705Search in Google Scholar

Blaheta R.A., Michaelis M., Hernaiz Driever P., Cinatl J. Jr.:Evolving anticancer drug valproic acid: Insights into the mechanism and clinical studies. Med. Res. Rev., 2005, 25: 383–397.10.1002/med.20027Search in Google Scholar

Bolanos A.R., Sarkisian M., Yang Y., Hori A., Heimers S.L., Mikati M. et al.:Comparison of valproate and Phenobarbital treatment after status epilepticus in rats. Neurology, 1998, 51: 41–48.10.1212/WNL.51.1.41Search in Google Scholar

Bootsma H.P.R., Coolen F., Aldenkamp A.P., Arends J., Diepman L., Hulsman J. et al.:Topiramate in clinical practice: longterm experience in patients with refractory epilepsy referred to tertiary epilepsy center. Epilepsy Behav., 2004, 5: 380–387.10.1016/j.yebeh.2004.03.002Search in Google Scholar

Borowicz K.K., Banach M., Zarczuk R., Lukasik D., Łuszczki J.J., Czuczwar S.J.:Acute and chronic treatment with mianserin differentially affects the anticonvulsant activity of conventional antiepileptic drugs in the mouse maximal electroshock model. Psychopharmacology, 2007a, 195: 167–174.10.1007/s00213-007-0878-9Search in Google Scholar

Borowicz K.K., Furmanek-Karwowska K., Sawicka K., Łuszczki J.J., Czuczwar S.J.:Chronically administered fluoxetine enhances the anticonvulsant activity of conventional antiepileptic drugs in the mouse maximal electroshock model. Eur. J. Pharmacol., 2007b, 567: 77–82.10.1016/j.ejphar.2007.03.015Search in Google Scholar

Borowicz K.K., Łuszczki J., Czuczwar S.J.:2-Chloroadenosine, a preferential agonist of adenosine A1 receptors, enhances the anticonvulsant activity of carbamazepine and clonazepam in mice. Eur. Neuropsychopharmacol., 2002a, 12: 173–179.10.1016/S0924-977X(02)00009-3Search in Google Scholar

Borowicz K.K., Świąder M., Zgrajka W., Sawulski C., Turski W.A., Czuczwar S.J.:Influence of several convulsants on the protective activity of a non-competitive AMPA/kainate antagonist, LY 300164, and lamotrigine against maximal electroshock in mice. J. Physiol. Pharmacol., 2002b, 53: 859–869.Search in Google Scholar

Bowden C.L., Calabrese J.R., McElroy S.L., Gyulai L., Wassef A., Petty F. et al.:A randomized, placebo-controlled 12-month trial of divalproex and lithium in the treatment of outpatients with bipolar I disorder. Arch. Gen. Psychiatry, 2000, 57: 481–489.10.1001/archpsyc.57.5.48110807488Search in Google Scholar

Brandt C., Gastens A.M., Sun M.Z., Hausknecht M., Löscher W.:Treatment with valproate after status epilepticus: effect on neuronal damage, epileptogenesis, and behavioral alterations in rats. Neuropharmacology, 2006, 51: 789–804.10.1016/j.neuropharm.2006.05.02116806297Search in Google Scholar

Brodie M.J., Schachter S.C.:Fast Facts. Epilepsy. 2^nd edn. Health Press, Oxford 2001.Search in Google Scholar

Calabrese J.R., Bowden C.L., Sachs G.S., Ascher J.A., Monagham E., Rudd G.D.:A double-blind placebo-controlled study of lamotrigine monotherapy in outpatients with bipolar I depression. J. Clin. Psychiatry, 1999, 60: 79–88.10.4088/JCP.v60n020310084633Search in Google Scholar

Calabresi P., Stefani A., Marfia G.A., Hainsworth A.H., Centonze D., Saulle E. et al.:Electrophysiology of sipatrigine: a lamotrigine derivative exhibiting neuroprotective effects. Exp. Neurol., 2000, 162: 171–179.10.1006/exnr.2000.728510716897Search in Google Scholar

Cascino G.D.:When drugs and surgery don’t work. Epilepsia, 2008, 49 (Suppl 9): 79–84.10.1111/j.1528-1167.2008.01930.x19087121Search in Google Scholar

Chrościńska M., Jargiełło M., Czuczwar S.J.:Influence of caffeine on the protective action of some conventional and novel antiepileptic drugs – an experimental evidence. Pharmacol. Rep., 2007, 59: 118.Search in Google Scholar

Cinatl J. Jr., Kotchetkov R., Blaheta R.A., Driever P.H., Vogel J.-U., Cinatl J.:Induction of differentiation and suppression of malignant phenotype of human neuroblastoma BE(2)-C cells by valproic acid: enhancement by combination with interferonalpha. Int. J. Oncol., 2002, 20: 97–106.10.3892/ijo.20.1.97Search in Google Scholar

Conti C.F., de Oliveira M.M., Valbuza J.S., Prado L.B., de Carvalho L.B., do Prado G.F.:Anticonvulsants to treat idiopathic restless legs syndrome. Arq. Neuropsiquiatr., 2008, 66: 431–435.10.1590/S0004-282X2008000300034Search in Google Scholar

Crumrine R.C., Bergstrand K., Cooper A.T., Faison W.L., Cooper B.R.:Lamotrigine protects hippocampal CA1 neurons from ischemic damage after cardiac arrest. Stroke, 1997, 28: 2230–2236. discussion 2237.10.1161/01.STR.28.11.22309368570Search in Google Scholar

Curia G., Longo D., Biagini G., Jones R.S.G., Avoli M.:The pilocarpine model of temporal lobe epilepsy. J. Neurosci. Methods, 2008, 172: 143–157.10.1016/j.jneumeth.2008.04.019251822018550176Search in Google Scholar

Czapinski P., Blaszczyk B., Czuczwar S.J.:Mechanisms of action of antiepileptic drugs. Curr. Top. Med. Chem., 2005, 5: 3–14.10.2174/156802605338696215638774Search in Google Scholar

Czuczwar P., Kaczmarczyk P., Czuczwar S.J.:New experimental data on the combinations of antiepileptic drugs. Epileptologia, 2009a, 17: 247–254.Search in Google Scholar

Czuczwar S.J., Kaplanski J., Swiderska-Dziewit G., Gergont A., Kroczka S., Kacinski M.:Pharmacodynamic interactions between antiepileptic drugs: preclinical data based on isobolography. Expert Opin. Drug Metab. Toxicol., 2009b, 5: 131–136.10.1517/1742525080267782619210232Search in Google Scholar

Dahlof C., Loder E., Diamond M., Rupnow M., Papadopoulos G., Mao L.:The impact of migraine prevention on daily activities: a longitudinal and responder analysis from three topiramate placebo-controlled clinical trials. Health Qual. Life Outcomes, 2007, 4: 56.10.1186/1477-7525-5-56209393017916258Search in Google Scholar

De Sarro G., Gratteri S., Bonacci F., Musumeci S.A., Elia M., De Sarro A.:Topiramate potentiates the antiseizure activity of some anticonvulsants in DBA/2 mice. Eur. J. Pharmacol., 2000, 388: 163–170.10.1016/S0014-2999(99)00779-7Search in Google Scholar

Deckers C.L.P., Czuczwar S.J., Hekster Y.A., Keyser A., Kubova H., Meinardi H. et al.:Selection of antiepileptic drug polytherapy based on mechanism of action: the evidence reviewed. Epilepsia, 2000, 41: 1364–1374.10.1111/j.1528-1157.2000.tb00111.x11077449Search in Google Scholar

Dinnerstein E., Jobst B.C., Williamson P.D.:Lamotrigine intoxication provoking status epilepticus in an adult with localization-related epilepsy. Arch. Neurol., 2007, 64: 1344–1346.10.1001/archneur.64.9.134417846277Search in Google Scholar

Doheny H.C., Whittington M.A., Jefferys J.G., Patsalos P.N.:A comparison of the efficacy of carbamazepine and the novel anti-epileptic drug levetiracetam in the tetanus toxin model of focal complex partial epilepsy. Br. J. Pharmacol., 2002, 135: 1425–1434.10.1038/sj.bjp.0704606157326811906955Search in Google Scholar

Domingues R.B., Kuster G.W., Aquino C.C.:Treatment of trigeminal neuralgia with low doses of topiramate. Arq. Neuropsiquiatr., 2007, 65: 792–794.10.1590/S0004-282X2007000500011Search in Google Scholar

Dudra-Jastrzębska M., Andres-Mach M.M., Łuszczki J.J., Czuczwar S.J.:Mood disorders in patients with epilepsy. Pharmacol. Rep., 2007, 59: 369–378.Search in Google Scholar

Eisensehr I., Ehrenberg B.L., Rogge Solti S., Noachtar S.:Treatment of idiopathic restless legs syndrome (RLS) with slow-release valproic acid compared with slow release levodopa/benserazid. J. Neurol., 2004, 5: 579–583.10.1007/s00415-004-0367-615164191Search in Google Scholar

Eyal S., Lamb J.G., Smith-Yockman M., Yagen B., Fibach E., Altschuler Y. et al.:The antiepileptic and anticancer agent, valproic acid, induces P-glycoprotein in human tumour cell lines and in rat liver. Brit. J. Pharmacol., 2006, 149: 250–260.10.1038/sj.bjp.0706830201427716894351Search in Google Scholar

Ferraro D., Di Trapani G.:Topiramate in the prevention of pediatric migraine: literature review. J. Headache Pain, 2008, 9: 147–150.10.1007/s10194-008-0030-1238684818385933Search in Google Scholar

Fisher R.S., van Emde Boas W., Blume W., Elger C., Genton P., Lee P. et al.:Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia, 2005, 46: 470–472.10.1111/j.0013-9580.2005.66104.x15816939Search in Google Scholar

Follett P.L., Deng W., Dai W., Talos D.M., Massillon L.J., Rosenberg P.A. et al.:Glutamate receptor-mediated oligodendrocyte toxicity in periventricular leukomalacia: A protective role for topiramate. J. Neurosci., 2004, 24: 4412–4420.10.1523/JNEUROSCI.0477-04.2004672945115128855Search in Google Scholar

French J.A., Kanner A.M., Bautista J., Abou-Khalil B., Browne T., Harden C.L. et al.:Efficacy and tolerability of the new antiepileptic drugs II: treatment of refractory epilepsy. Report of the therapeutics and technology assessment subcommittee and quality standards subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology, 2004, 62: 1261–1273.10.1212/01.WNL.0000123695.22623.32Search in Google Scholar

Frye M.A., Ketter T.A., Kimbrell T.A., Dunn R.T., Speer A.M., Osuch E.A. et al.:A placebo-controlled study of lamotrigine and gabapentin monotherapy in refractory mood disorders. J. Clin. Psychopharmacol., 2000, 20: 607–614.10.1097/00004714-200012000-00004Search in Google Scholar

Gilron I., Booher S.L., Rowan J.S., Max M.B.:Topiramate in trigeminal neuralgia: a randomized, placebo-controlled, multiple crossover pilot study. Clin. Neuropharmacol., 2001, 24: 109–112.10.1097/00002826-200103000-00009Search in Google Scholar

Gracia-Naya M., Latorre-Jiménez A.M., Ríos-Gómez C., Santos-Lasaosa S., Mauri J.A., Sánchez-Valiente S. et al.:Topiramate in chronic daily headache due to migraine. Rev. Neurol., 2007, 45: 456–459.10.33588/rn.4508.2007265Search in Google Scholar

Hanaya R., Sasa M., Ujihara H., Ishihara K., Serikawa T., Iida K. et al.:Suppression by topiramate of epileptiform burst discharges in hippocampal CA3 neurons of spontaneously epileptic rat in vitro. Brain Res., 1998, 789: 274–282.10.1016/S0006-8993(98)00116-4Search in Google Scholar

Hanon E., Klitgaard H.:Neuroprotective properties of the novel antiepileptic drug levetiracetam in the rat middle cerebral artery occlusion model of focal cerebral ischemia. Seizure, 2001, 10: 287–293.10.1053/seiz.2000.051111466025Search in Google Scholar

Hawker K., Frohman E., Racke M.:Levetiracetam for phasic spasticity in multiple sclerosis. Arch. Neurol., 2003, 60: 1772–1774.10.1001/archneur.60.12.177214676055Search in Google Scholar

Jankiewicz K., Chrościńska-Krawczyk M., Błaszczyk B., Czuczwar S.J:Kofeina a leki przeciwpadaczkowe: dane doświadczal-ne i kliniczne. Przeg. Lek., 2007, 64: 965–967.Search in Google Scholar

Jędrzejczak J., Kuncikova M., Magureanu S., VIPe Study Group:An observational study of first-line valproate monotherapy in focal epilepsy. Eur. J. Neurol., 2008, 15: 66–72.Search in Google Scholar

Kelly K., Stephen L.J., Sills G.J., Brodie M.J.:Topiramate in patients with learning disability and refractory epilepsy. Epilepsia, 2002, 43: 399–402.10.1046/j.1528-1157.2002.47401.x11952770Search in Google Scholar

Koinig H., Morimoto Y., Zornow M.H.:The combination of lamotrigine and mild hypothermia prevents ischemia-induced increase in hippocampal glutamate. J. Neurosurg. Anesthesiol., 2001, 13: 106–112.10.1097/00008506-200104000-0000711294451Search in Google Scholar

Kwan P., Brodie M.:Early identification of refractory epilepsy. N. Engl. J. Med., 2000, 342: 314–319.10.1056/NEJM20000203342050310660394Search in Google Scholar

Lampl C., Katsarava Z., Diener H.C., Limmroth V.:Lamotrigine reduces migraine aura and migraine attacks in patients with migraine with aura. J. Neurol. Neurosurg. Psychiat., 2005, 76: 1730–1732.10.1136/jnnp.2005.063750Search in Google Scholar

Lasoń W., Dudra-Jastrzębska M., Rejdak K., Czuczwar S.J.:Basic mechanisms of antiepileptic drugs and their pharmacokinetic/pharmacodynamic interactions – an update. Pharmacol. Rep., 2011, 63: 271–292.10.1016/S1734-1140(11)70497-2Search in Google Scholar

Leach J.P., Brodie M.J.:New antiepileptic drugs – an explosion of activity. Seizure, 1995, 4: 5–17.10.1016/S1059-1311(05)80074-3Search in Google Scholar

Lee C.Y., Fu W.M., Chen C.C., Su M.J., Liou H.H.:Lamotrigine inhibits postsynaptic AMPA receptor and glutamate release in the dentate gyrus. Epilepsia, 2008a, 49: 588–597.10.1111/j.1528-1167.2007.01526.xSearch in Google Scholar

Lee J.H., Hwang Y.S., Shin J.J., Kim T.H., Shin H.S., Park S.K.:Surgical complications of epilepsy surgery procedures: experience of 179 procedures in a single institute. J. Korean Neurosurg. Soc., 2008b, 44: 234–239.10.3340/jkns.2008.44.4.234Search in Google Scholar

Lee H.O., Koh E.J., Oh Y.M., Park S.S., Kwon K.H., Choi H.Y.:Effect of vagus nerve stimulation in post-traumatic epilepsy and failed epilepsy surgery: preliminary report. J. Korean Neurosurg. Soc., 2008c, 44: 196–198.10.3340/jkns.2008.44.4.196Search in Google Scholar

Lee W.T., Shen Y.Z., Chang C.:Neuroprotective effect of lamotrigine and MK-801 on rat brain lesions induced by 3-nitro-propionic acid: evaluation by magnetic resonance imaging and in vivo proton magnetic resonance spectroscopy. Neuroscience, 2000, 95: 89–95.10.1016/S0306-4522(99)00410-8Search in Google Scholar

Leker R.R., Neufeld M.Y.:Anti-epileptic drugs as possible neuroprotectants in cerebral ischemia. Brain Res., 2003, 42: 187–203.10.1016/S0165-0173(03)00170-XSearch in Google Scholar

Li X., Ketter T.A., Frye M.A.:Synaptic, intracellular, and neuroprotective mechanisms of anticonvulsants: are they relevant for the treatment and course of bipolar disorders? J. Affect. Disord., 2002, 69: 1–14.10.1016/S0165-0327(00)00361-XSearch in Google Scholar

Lin D., Mok H., Yatham L.N.:Polytherapy in bipolar disorder. CNS Drugs, 2006, 20: 29–42.10.2165/00023210-200620010-0000316396522Search in Google Scholar

Liu Y., Barks J.D., Xu G., Silverstein F.S.:Topiramate extends the therapeutic window for hypothermia-mediated neuroprotection after stroke in neonatal rats. Stroke, 2004, 35: 1460–1465.10.1161/01.STR.0000128029.50221.faSearch in Google Scholar

Löscher W.:Basic pharmacology of valproate. CNS Drugs, 2002, 16: 669–694.10.2165/00023210-200216100-00003Search in Google Scholar

Löscher W., Fassbender C.P., Nolting B.:The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. II. Maximal electroshock seizure models. Epilepsy Res., 1991, 8: 79–94.10.1016/0920-1211(91)90075-QSearch in Google Scholar

Löscher W., Potschka H.:Role of multidrug transporters in pharmacoresistance to antiepileptic drugs. J. Pharmacol. Exp. Ther., 2002, 301: 7–14.10.1124/jpet.301.1.711907151Search in Google Scholar

Lukyanetz E.A., Shkryl V.M., Kostyuk P.G.:Selective blockade of N-type calcium channels by levetiracetam. Epilepsia, 2002, 43: 9–18.10.1046/j.1528-1157.2002.24501.x11879381Search in Google Scholar

Lynch B.A., Lambeng N., Nocka K., Kensel-Hammes P., Bajjalieh S.M., Matagne A. et al.:The synaptic vesicle protein SV2A in the binding site for the antiepileptic drug levetiracetam. Proc. Natl. Acad. Sci. USA, 2004, 101: 9861–9866.10.1073/pnas.030820810147076415210974Search in Google Scholar

Łuszczki J.J., Czernecki R., Wojtal K., Borowicz K.K., Czuczwar S.J.:Agmatine enhances the anticonvulsant action of phenobarbital and valproate in the mouse maximal electroshock seizure model. J. Neural Transm., 2008, 115: 1485–1494.10.1007/s00702-008-0046-318379717Search in Google Scholar

Łuszczki J.J., Danysz W., Czuczwar S.J.:Interactions of MRZ 2/576 with febamate, lamotrygine, oxcarbazepine and topiramate in the mouse maximal electroshock – induced seizure model. Pharmacology, 2008, 81: 259–265.10.1159/00011487018253065Search in Google Scholar

Łuszczki J.J., Kozicka M., Świąder M.J., Czuczwar S.J.:2-Chlo-ro-N6-cyclopentyladenosine enhances the anticonvulsant action of carbamazepine in the mouse maximal electroshock-induced seizure model. Pharmacol. Rep., 2005, 57: 787–792.Search in Google Scholar

Łuszczki J.J., Sawicka K.M, Kozińska J., Dudra-Jastrzębska M., Czuczwar S.J.:Amiloride enhances the anticonvulsant action of various antiepileptic drugs in the mouse maximal electroshock seizure model. J. Neural. Transm., 2009, 116: 57–66.10.1007/s00702-008-0152-219030777Search in Google Scholar

Łuszczki J.J., Sawicka K.M., Kozinska J., Borowicz K.K., Czuczwar S.J.:Furosemide potentiates the anticonvulsant action of valproate in the mouse maximal electroshock seizure model. Epilepsy Res., 2007a, 76: 66–72.10.1016/j.eplepsyres.2007.06.01017659862Search in Google Scholar

Łuszczki J.J., Trojnar M.K., Trojnar M.P., Kimber-Trojnar Ż., Szostakiewicz B., Zadrożniak B. et al.:Effects of three calcium channel antagonists (amlodipine, diltiazem and verapamil) on the protective action of lamotrigine in the mouse maximal electroshock – induced seizure model. Pharmacol. Rep., 2007b, 59: 672–682.Search in Google Scholar

Macdonald R.L., Kelly K.M.:Antiepileptic drug mechanisms of action. Epilepsia, 1995, 36: 2–12.10.1111/j.1528-1157.1995.tb05996.xSearch in Google Scholar

Maj R., Fariello R.G., Ukmar G., Varasi M., Pevarello P., McArthur R.A. et al:PNU-151774E protects against kainate-induced status epilepticus and hippocampal lesions in the rat. Eur. J. Pharmacol., 1998, 359: 27–32.10.1016/S0014-2999(98)00554-8Search in Google Scholar

Majkowski J.:One-year observation of topiramate in add-on therapy in patients with drug resistant epilepsy. Epileptologia, 2004a, 12: 55–64.Search in Google Scholar

Majkowski J.:Advances in characteristics and pathogenesis understanding of drug resistant epilepsy. Epileptologia, 2004b, 12: 137–147.Search in Google Scholar

Majkowski J.:The place of epileptology in the contemporary medicine – from research to practice. Epileptologia, 2006, 14: 263–273.Search in Google Scholar

Majkowski J., Neto W., Wapenaar R., Van Oene J.:Time course of adverse events in patients with localization – related epilepsy receiving topiramate added to carbamazepine. Epilepsia, 2005, 46: 648–653.10.1111/j.1528-1167.2005.35904.xSearch in Google Scholar

Małek R., Borowicz K.K., Kimber-Trojnar Z., Sobieszek G., Piskorska B., Czuczwar S.J.:Remacemide – a novel potential antiepileptic drug. Pol. J. Pharmacol., 2003, 55: 691–698.Search in Google Scholar

Mapstone T.B.:Vagus nerve stimulation: current concepts. Neu-rosurg. Focus, 2008, 25: E9.10.3171/FOC/2008/25/9/E9Search in Google Scholar

Margolin A., Avants S.K., DePhilips D., Kosten T.R.:A preliminary investigation of lamotrygine for cocaine abuse in HIV-seropositive patients. Am. J. Drug. Alcohol Abuse, 1998, 24: 85–101.10.3109/00952999809001700Search in Google Scholar

Marson A.G., Al-Kharusi A.M., Alwaidh M., Appleton R., Baker G.A., Chadwick D.W. et al:The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randqeomised controlled trial. Lancet, 2007, 369: 1000–1015.10.1016/S0140-6736(07)60460-7Search in Google Scholar

Marson A.G., Hutton J.L., Leach J.P., Castillo S., Schmidt D., White S. et al.:Levetiracetam, oxcarbazepine, remacemide and zonisamide for drug resistant localization-related epilepsy: a systematic review. Epilepsy Res., 2001, 46: 259–270.10.1016/S0920-1211(01)00287-XSearch in Google Scholar

Mazarati A.M., Baldwin R., Klitgaard H., Matagne A., Wasterlain C.G.:Anticonvulsant effects of levetiracetam and levetiracetam-diazepam combinations in experimental status epilepticus. Epilepsy Res., 2004, 58: 167–174.10.1016/j.eplepsyres.2004.02.00215120747Search in Google Scholar

Morland C., Boldingh K.A., Iversen E.G., Hassel B.:Valproate is neuroprotective against malonate toxicity in rat striatum: An association with augmentation of high-affinity glutamate uptake. J. Cereb. Blood Flow Metab., 2004, 24: 1226–1234.10.1097/01.WCB.0000138666.25305.A715545916Search in Google Scholar

Murakami A., Ishikawa T., Takechi K., Ago J., Matsumoto N., Kamei C.:Effects of certain antiepileptics on behavioral and electromyographic seizure patterns induced by maximal electroshock in mice. J. Pharmacol. Sci., 2007, 104: 56–60.10.1254/jphs.FP006148717452808Search in Google Scholar

Nakamura J., Tamura S., Kanda T., Ishii A., Ishihara K., Seri-kawa T. et al.:Inhibition by topiramate of seizures in spontaneously epileptic rats and DBA/2 mice. Eur. J. Pharmacol., 1994, 254: 83–89.10.1016/0014-2999(94)90373-5Search in Google Scholar

Niespodziany I., Klitgaard H., Margineanu D.G.:Levetiracetam inhibits the high-voltage-activated Ca²⁺, current in pyramidal neurones of rat hippocampl slices. Neurosci. Lett., 2001, 306: 5–8.10.1016/S0304-3940(01)01884-5Search in Google Scholar

Otoul C., Arrigo C., Rijckevorsel K.V., French J.A.:Metaanalysis and indirect comparisons of levetiracetam with other second-generation antiepileptic drugs in partial epilepsy. Clin. Neuropharmacol., 2005, 28: 72–78.10.1097/01.wnf.0000159956.87511.67Search in Google Scholar

Owens M.J., Nemeroff C.B.:Pharmacology of valproate. Psychopharmacol. Bull., 2003, 37 (Suppl 2): 17–25.Search in Google Scholar

Papazisis G., Kallaras K., Kaiki-Astara A., Pourzitaki C., Tzachanis D., Dagklis T. et al.:Neuroprotection by lamotrigine in a rat model of neonatal hypoxic-ischaemic encephalopathy. Int. J. Neuropsychopharmacol., 2008, 1: 321–329.10.1017/S1461145707008012Search in Google Scholar

Patsalos P.N:Clinical pharmacokinetics of levetiracetam. Clin. Pharmacokinet., 2004, 43: 707–724.10.2165/00003088-200443110-00002Search in Google Scholar

Perucca E.:Clinically relevant drug interactions with antiepileptic drugs. Brit. J. Clin. Pharmacol., 2006, 61: 246–255.10.1111/j.1365-2125.2005.02529.xSearch in Google Scholar

Pitkanen A.:Efficacy of current antiepileptics to prevent neurodegeneration in epilepsy models. Epilepsy Res., 2002, 50: 141–160.10.1016/S0920-1211(02)00076-1Search in Google Scholar

Remy S., Beck H.:Molecular and cellular mechanisms of pharmacoresistance in epilepsy. Brain, 2006, 129: 18–35.10.1093/brain/awh68216317026Search in Google Scholar

Ren M., Leng Y., Jeong M., Leeds P.R., Chuang D.M.:Valproic acid reduces brain damage induced by transient focal cerebral ischemia in rats: potential roles of histone deacetylase inhibition and heat shock peotein induction. J. Neurochem., 2004, 89: 1358–1367.10.1111/j.1471-4159.2004.02406.x15189338Search in Google Scholar

Rigo J.M., Hans G., Nguyen L., Rocher V., Belachew S., Malgrange B. et al.:The anti-epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA – and glycine. Br. J. Pharmacol., 2002, 136: 659–672.10.1038/sj.bjp.0704766157339612086975Search in Google Scholar

Sabers A., Gram L.:Newer anticonvulsants: comparative review of drug interactions and adverse effects. Drugs, 2000, 60: 23–33.10.2165/00003495-200060010-00003Search in Google Scholar

Sardo P., Ferraro G.:Modulatory effects of nitric oxide-active drugs on the anticonvulsant activity of lamotrigine in an experimental model of partial complex epilepsy in the rat. BMC Neurosci., 2007, 8: 47.10.1186/1471-2202-8-47Search in Google Scholar

Schneiderman J.H.:Topiramate: pharmacokinetics and pharmacodynamics. Can. J. Neurol. Sci., 1998, 25: 3–5.10.1017/S031716710003482XSearch in Google Scholar

Shuaib A., Mahmood R.H., Wishart T., Kanthan R., Murabit M.A., Iljaz S. et al.:Neuroprotective effects of lamotrigine in global ischemia in gerbils. A histological, in vivo microdialysis and behavioral study. Brain Res., 1995, 702: 199–206.10.1016/0006-8993(95)01048-1Search in Google Scholar

Sills G.J., Butler E., Thompson G.G., Brodie M.J.:Pharmacodynamic interaction studies with topiramate in the pentylenetetrazol and maximal electroshock seizure models. Seizure, 2004, 13: 287–295.10.1016/S1059-1311(03)00185-7Search in Google Scholar

Sindrup S.H., Jensen T.S.:Pharmacotherapy of trigeminal neuralgia. Clin. J. Pain, 2002, 18: 22–27.10.1097/00002508-200201000-0000411803299Search in Google Scholar

Skradski S., White H.S.:Topiramate blocks kainate-evoked cobalt influx into cultured neurons. Epilepsia, 2000, 41: 45–47.10.1111/j.1528-1157.2000.tb02171.x10768300Search in Google Scholar

Sobaniec W., Kułak W., Strzelecka J., Śmigielska-Kuzia J., Boćkowski L.:A comparative study of vigabatrin vs. carbamazepine in monotherapy of newly diagnosed partial seizures in children. Pharmacol. Rep., 2005, 57: 646–653.Search in Google Scholar

Sousa Pda S., Araujo Filho G.M., Garzon E., Sakamoto A.C., Yacubian E.M.:Topiramate for the treatment of juvenile myoclonic epilepsy. Arq. Neuropsiquiatr., 2005, 63: 733–737.10.1590/S0004-282X2005000500001Search in Google Scholar

Stępień K., Tomaszewski M., Czuczwar S.J.:Profile of anticonvulsant activity and neuroprotective effects of novel and potential antiepileptic drugs – an update. Pharmacol. Rep., 2005, 57: 719–733.Search in Google Scholar

Suda S., Katsura K., Kanamaru T., Saito M., Katayama Y.:Valproic acid attenuates ischemia-reperfusion injury in the rat brain through inhibition of oxidative stress and inflammation. Eur. J. Pharmacol., 2013, 707: 26–31.10.1016/j.ejphar.2013.03.02023541723Search in Google Scholar

Świąder M.J., Łuszczki J.J., Zwolan A., Wielosz M., Czuczwar S.J:Effects of some convulsant agents on the protective activity of TPM against maximal electroshock-induced seizures in mice. Pharmacol. Rep., 2005, 57: 373–379.Search in Google Scholar

Tomczyk T., Haberek G., Zuchora B., Jarosławska-Zych A., Kowalczyk M.S., Wielosz M. et al.:Enhanced glutamatergic transmission reduces the anticonvulsant potential of lamotrigine but not of felbamate against tonic-clonic seizures. Pharmacol. Rep., 2007, 59: 462–466.Search in Google Scholar

Toth M.:The epsilon theory: a novel synthesis of the underlying molecular and electrophysiological mechanisms of primary generalized epilepsy and the possible mechanism of action of valproate. Med. Hypotheses, 2005, 64: 267–272.10.1016/j.mehy.2004.07.01915607553Search in Google Scholar

Trojnar M.K., Małek R., Chrościńska M., Nowak S., Błasz-czyk B., Czuczwar S.J.:Neuroprotective effects of antiepileptic drugs. Pol. J. Pharmacol., 2002, 54: 557–566.Search in Google Scholar

Tutor-Crespo M.J., Hermida J., Tutor J.C.:Relative proportions of serum carbamazepine and its pharmacologically active 10, 11-epoxy derivative: effect of polytherapy and renal insufficiency. Upsala J. Med. Sci., 2008, 113: 171–180.10.3109/2000-1967-225Search in Google Scholar

Vazquez B.:Monotherapy in Epilepsy. Role of the newer antiepileptic drugs. Arch. Neurol., 2004, 61: 1361–1365.10.1001/archneur.61.9.1361Search in Google Scholar

Vitezic D., Pelcic J.M., Zupan G., Vitezic M., Ljubicic D., Si-monic A.:NA⁺, K⁺-ATPase activity in the brain of the rats with kainic acid-induced seizures: influence of lamotrigine. Psychiatr. Danub., 2008, 20: 269–276.Search in Google Scholar

Wheless J.W., Clarke D.F., Arzimanoglou A., Carpenter D.:Treatment of pediatric epilepsy: European expert opinion, 2007. Epileptic Disord., 2007, 9: 353–412.Search in Google Scholar

White H.S., Brown SD., Woodhead J.H., Skeen G.A., Wolf H.H.:Topiramate enhances GABA-mediated chloride flux and GABA-evoked chloride currents in murine brain neurons and increases seizure threshold. Epilepsy Res., 1997, 28: 167–179.10.1016/S0920-1211(97)00045-4Search in Google Scholar

Wiard R.P., Dickerson M.C., Beek O., Norton R., Cooper B.R.:Neuroprotective properties of the novel antiepileptic lamotrigine in a gerbil model of global cerebral ischemia. Stroke, 1995, 26: 466–472.10.1161/01.STR.26.3.466Search in Google Scholar

Wilby J., Kainth A., Hawkins N., Epstein D., McIntosh H., McDaid C. et al.:Clinical effectiveness, tolerability and costeffectiveness of newer drugs for epilepsy in adults: a systematic review and economic evaluation. Health Technol. Assessm., 2005, 9: 1–157.10.3310/hta9150Search in Google Scholar

Wojtal K., Borowicz K.K., Błaszczyk B., Czuczwar S.J.:Interactions of excitatory amino acid receptor antagonists with antiepileptic drugs in three basic models of experimental epilepsy. Pharmacol. Rep., 2006, 58: 587–598.Search in Google Scholar

Xia Q., Sung J., Chowdhury W., Chen C., Hoti N., Shabbeer S.:Chronic administration of valproic acid inhibits prostate cancer cell growth in vitro and in vivo. Cancer Res., 2006, 66: 7237–7244.10.1158/0008-5472.CAN-05-0487Search in Google Scholar

Yang Y., Shuaib A., Li Q., Siddiqui M.M.:Neuroprotection by delayed administration of topiramate in a rat model of middle cerebral artery embolization. Brain Res., 1998, 804: 169–176.10.1016/S0006-8993(98)00410-7Search in Google Scholar

Zaccara G., Messori A., Cincotta M., Burchini G.:Comparison of the efficacy and tolerability of new antiepileptic drugs: what can we learn from long-term studies? Acta Neurol. Scand., 2006, 114: 157–168.10.1111/j.1600-0404.2006.00705.xSearch in Google Scholar

Zakrzewska J.M., Chaudry Z., Nurmikko T.J., Patton D.W., Mullens E.L.:Lamotrigine (Lamictal) in refractory trigeminal neuralgia: results from a double-blind, placebo controlled trial. Pain, 1997, 73: 223–230.10.1016/S0304-3959(97)00104-8Search in Google Scholar

Zaremba P.D., Białek M., Błaszczyk B., Cioczek P., Czuczwar S.J.:Non-epilepsy uses of antiepileptic drugs. Pharmacol. Rep., 2006, 58: 1–12.Search in Google Scholar

Zhang X., Velumian A..A, Jones O.T., Carlen P.L.:Modulation of high-voltage-activated calcium channels in dentate granule cells by topiramate. Epilepsia, 2000, 41: 52–60.10.1111/j.1528-1157.2000.tb02173.x10768302Search in Google Scholar