<abstract xmlns="http://www.w3.org/1999/xhtml">P1H, a newly discovered compound antigen associated with both the ABO and P systems, occurs in approximately 7 percent of Natal (South African) blacks. The compound antigen is evident only when the red cells have exceptionally strong expression of both P1 and H antigens, and it is apparently a dominant character. The antigen is thought to originate by steric rearrangement in the molecule, or to be the product of competition between <italic>P</italic>1 and <italic>H</italic> gene transferases for the available paragloboside. The corresponding antibody, anti-P1H, has been made by both P2 and P2 people and is a weak cold agglutinin. It is not adsorbed by red cells carrying either strongly expressed P1 or H antigens, but is adsorbed by and eluted from P1H+ red cells sensitized by anti-P1H. The antibody is inhibited by P1 but not by H, Lewis, or Sda substances. <bold><italic>Immunohematology</italic></bold> 1993;9:7.</abstract>

P1H, a newly discovered compound antigen associated with both the ABO and P systems, occurs in approximately 7 percent of Natal (South African) blacks. The compound antigen is evident only when the red cells have exceptionally strong expression of both P1 and H antigens, and it is apparently a dominant character. The antigen is thought to originate by steric rearrangement in the molecule, or to be the product of competition between P1 and H gene transferases for the available paragloboside. The corresponding antibody, anti-P1H, has been made by both P2 and P2 people and is a weak cold agglutinin. It is not adsorbed by red cells carrying either strongly expressed P1 or H antigens, but is adsorbed by and eluted from P1H+ red cells sensitized by anti-P1H. The antibody is inhibited by P1 but not by H, Lewis, or Sda substances. Immunohematology 1993;9:7.

The P1H antigen and antibody

Immunohematology

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P1H, a newly discovered compound antigen associated with both the ABO and P systems, occurs in approximately 7 percent of Natal (South African) blacks. The...

The P₁H antigen and antibody

Publicado en línea: 12 jun 2018

Páginas: 7 - 10

DOI: https://doi.org/10.21307/immunohematology-2019-948

© 1993 P.P. MOORES., published by Sciendo