<abstract xmlns="http://www.w3.org/1999/xhtml">A screening program was implemented to identify hrB– donors. D– C+, D–C–, and D+C– samples from African-American donors were typed with multiple examples of anti-hrB and anti-hrB-like, and one example each of anti-V and anti-VS. Of 75 D–C+ donors, 4 (5%) typed as hrB–, and 14 others had weak or variable expression of hrB. Of these 18 individuals, 15 were V–VS+, and 3 were V+VS+. No hrB– sample was found in 90 C– donors, 26 of whom were V+VS+, and 1 was V–VS+. A review of our records of 44 hrB– patients and donors studied earlier revealed that at least 12, and possibly as many as 30, carried <italic>r′</italic> or <italic>r′s</italic>. All hrB– donors found in our screening program had D–C+VS+ RBCs, indicating an overrepresentation of <italic>r′</italic>. Our record review also showed that the presence of <italic>r′</italic> and <italic>r′s</italic> more often results in hrB– RBCs, and that the most effective way to screen for hrB– donors is to type African Americans who have D–C+ RBCs. <bold><italic>Immunohematology</italic></bold> 1995;11:74–77.</abstract>

A screening program was implemented to identify hrB– donors. D– C+, D–C–, and D+C– samples from African-American donors were typed with multiple examples of anti-hrB and anti-hrB-like, and one example each of anti-V and anti-VS. Of 75 D–C+ donors, 4 (5%) typed as hrB–, and 14 others had weak or variable expression of hrB. Of these 18 individuals, 15 were V–VS+, and 3 were V+VS+. No hrB– sample was found in 90 C– donors, 26 of whom were V+VS+, and 1 was V–VS+. A review of our records of 44 hrB– patients and donors studied earlier revealed that at least 12, and possibly as many as 30, carried r′ or r′s. All hrB– donors found in our screening program had D–C+VS+ RBCs, indicating an overrepresentation of r′. Our record review also showed that the presence of r′ and r′s more often results in hrB– RBCs, and that the most effective way to screen for hrB– donors is to type African Americans who have D–C+ RBCs. Immunohematology 1995;11:74–77.

The <italic>r′</italic> gene is overrepresented in hrB-negative individuals

Immunohematology

The  gene is overrepresented in hr-negative individuals

A screening program was implemented to identify hrB– donors. D– C+, D–C–, and D+C– samples from African-American donors were typed with multiple examples of...

The r′ gene is overrepresented in hr^B-negative individuals

Publicado en línea: 17 nov 2020

Páginas: 74 - 77

DOI: https://doi.org/10.21307/immunohematology-2019-793

© 1995 C. L. Beal et al., published by Sciendo

The r′ gene is overrepresented in hrB-negative individuals

Publicado en línea: 17 nov 2020

Páginas: 74 - 77

DOI: https://doi.org/10.21307/immunohematology-2019-793

© 1995 C. L. Beal et al., published by Sciendo

The r′ gene is overrepresented in hr^B-negative individuals