<abstract xmlns="http://www.w3.org/1999/xhtml"><p>We describe the second example of red blood cells (RBCs) with the Lu:–7 phenotype in a 37-year-old Latino female (SA). Her RBCs were nonreactive with anti-Lu7 (Mrs. GA) but were reactive with all other antibodies to high-prevalence antigens tested, including those in the Lutheran blood group system. No Lu:–7 RBCs were available for testing. SA’s serum was nonreactive by the indirect antiglobulin test against (1) recessive and dominant Lu(a–b–) RBCs and (2) trypsin-treated or <italic>α</italic>-chymotrypsin-treated RBCs of common phenotype. By immunoblotting, eluates containing anti-Lu7 from both Mrs. GA and SA reacted with apparently the same bands in RBC membranes of common phenotype as did human anti-Lu<sup>b</sup>, reacted weakly with Lu(a–b–) RBCs of the dominant type, and were nonreactive with SA’s RBC membranes. These findings raise the Lu7 antigen from its Lutheran-related (para-Lutheran) status to a bona fide member of the Lutheran blood group system. <bold><italic>Immunohematology</italic></bold> 1996;12:66–68.</p></abstract>

We describe the second example of red blood cells (RBCs) with the Lu:–7 phenotype in a 37-year-old Latino female (SA). Her RBCs were nonreactive with anti-Lu7 (Mrs. GA) but were reactive with all other antibodies to high-prevalence antigens tested, including those in the Lutheran blood group system. No Lu:–7 RBCs were available for testing. SA’s serum was nonreactive by the indirect antiglobulin test against (1) recessive and dominant Lu(a–b–) RBCs and (2) trypsin-treated or α-chymotrypsin-treated RBCs of common phenotype. By immunoblotting, eluates containing anti-Lu7 from both Mrs. GA and SA reacted with apparently the same bands in RBC membranes of common phenotype as did human anti-Lub, reacted weakly with Lu(a–b–) RBCs of the dominant type, and were nonreactive with SA’s RBC membranes. These findings raise the Lu7 antigen from its Lutheran-related (para-Lutheran) status to a bona fide member of the Lutheran blood group system. Immunohematology 1996;12:66–68.

The second example of Lu:-7 phenotype: serology and immunochemical studies

Immunohematology

{"article-title":"The second example of Lu:-7 phenotype: serology and immunochemical studies"}

We describe the second example of red blood cells (RBCs) with the Lu:–7 phenotype in a 37-year-old Latino female (SA). Her RBCs were nonreactive with anti-Lu7...

The second example of Lu:-7 phenotype: serology and immunochemical studies

Publicado en línea: 10 nov 2020

Páginas: 66 - 68

DOI: https://doi.org/10.21307/immunohematology-2019-748

© 1996 M.E. Reid et al., published by Sciendo