The gel system has been reported to be more sensitive and specific than the conventional tube indirect antiglobulin test (IAT) for antibody screening. However, a major concern about the gel system is its cost. A cost analysis study was therefore conducted at our hospital. The gel system costs more than the conventional tube IAT per test; however, the total staff and reagent costs per year were about equal, because of staff savings. Workload and cost per patient requiring blood were reduced using the gel system.