<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Many drugs, including antibiotics such as gentamicin, have been associated with the development of a drug-induced thrombocytopenia. Serologic methods for detection of drug-dependent plateIet antibodies (DDPAs) are not routinely performed, and the incidence of such antibody-mediated thrombocytopenia is not known. As we routinely perform solid-phase red cell adherence assays for the detection of DDPAs, a study was designed to determine the incidence of gentamicin-associated platelet antibodies (GAPAs) in our institution. Adult patients who received gentamicin from 1/1/98 to 7/31/98 were evaluated for inclusion in the study. Testing for the presence of GAPAs was performed if the patient had a decrease in platelet count while receiving gentamicin or if the platelet count increased or decreased within 3 days of the last gentamicin therapy. Patients receiving gentamicin without development of thrombocytopenia were tested as controls. During the study period, 926 patients received gentamicin, with 324 (35%) being evaluated for the presence of GAPAs; GAPAs were identified in 25 of 659 patients (4%) eligible for the study. All control samples were found to lack GAPAs. If only patients exhibiting changes in platelet counts are considered, the incidence increases to 7.7 percent, with females apparently being almost twice as likely to develop GAPAs than are males. Gentamicin-associated thrombocytopenia is not an infrequent occurrence in hospitalized patients. <bold><italic>Immunohematalogy</italic></bold> 1999;15:167-170.</p></abstract>

Many drugs, including antibiotics such as gentamicin, have been associated with the development of a drug-induced thrombocytopenia. Serologic methods for detection of drug-dependent plateIet antibodies (DDPAs) are not routinely performed, and the incidence of such antibody-mediated thrombocytopenia is not known. As we routinely perform solid-phase red cell adherence assays for the detection of DDPAs, a study was designed to determine the incidence of gentamicin-associated platelet antibodies (GAPAs) in our institution. Adult patients who received gentamicin from 1/1/98 to 7/31/98 were evaluated for inclusion in the study. Testing for the presence of GAPAs was performed if the patient had a decrease in platelet count while receiving gentamicin or if the platelet count increased or decreased within 3 days of the last gentamicin therapy. Patients receiving gentamicin without development of thrombocytopenia were tested as controls. During the study period, 926 patients received gentamicin, with 324 (35%) being evaluated for the presence of GAPAs; GAPAs were identified in 25 of 659 patients (4%) eligible for the study. All control samples were found to lack GAPAs. If only patients exhibiting changes in platelet counts are considered, the incidence increases to 7.7 percent, with females apparently being almost twice as likely to develop GAPAs than are males. Gentamicin-associated thrombocytopenia is not an infrequent occurrence in hospitalized patients. Immunohematalogy 1999;15:167-170.

Frequency of thrombocytopenia associated with gentamicin therapy

Immunohematology

{"article-title":"Frequency of thrombocytopenia associated with gentamicin therapy"}

Many drugs, including antibiotics such as gentamicin, have been associated with the development of a drug-induced thrombocytopenia. Serologic methods for...

Frequency of thrombocytopenia associated with gentamicin therapy

Publicado en línea: 26 oct 2020

Páginas: 167 - 170

DOI: https://doi.org/10.21307/immunohematology-2019-640

Palabras clave
gentamicin-dependent platelet antibodies, thrombocytopenia, platelets

© 1999 M.F Leach et al., published by Sciendo

Frequency of thrombocytopenia associated with gentamicin therapy

Publicado en línea: 26 oct 2020

Páginas: 167 - 170

DOI: https://doi.org/10.21307/immunohematology-2019-640

Palabras clavegentamicin-dependent platelet antibodies, thrombocytopenia, platelets

© 1999 M.F Leach et al., published by Sciendo

Palabras clave
gentamicin-dependent platelet antibodies, thrombocytopenia, platelets