<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Low concentrations of sodium hypochlorite (chlorine bleach) are known to destroy S antigen on intact fresh red blood cells (RBCs). Sodium hypochlorite is commonly used as a disinfectant. We report nondetection of the S antigen in tube and microplate saline indirect antiglobulin testing (SIAT) with a lot of commercial saline utilized in our donor screening and reference laboratories. Known S+s+ RBCs were found to be nonreactive with anti-S by SIAT in our reference laboratory. Our investigation demonstrated the presence of chlorine in the commercial saline. The saline lot was used for several days of donor screening and recall of FFP and platelet concentrates was initiated. Two lots of saline were recalled from blood banks across North America. <bold><italic>Immunohematology</italic> 18;3: 120–122.</bold></p></abstract>

Low concentrations of sodium hypochlorite (chlorine bleach) are known to destroy S antigen on intact fresh red blood cells (RBCs). Sodium hypochlorite is commonly used as a disinfectant. We report nondetection of the S antigen in tube and microplate saline indirect antiglobulin testing (SIAT) with a lot of commercial saline utilized in our donor screening and reference laboratories. Known S+s+ RBCs were found to be nonreactive with anti-S by SIAT in our reference laboratory. Our investigation demonstrated the presence of chlorine in the commercial saline. The saline lot was used for several days of donor screening and recall of FFP and platelet concentrates was initiated. Two lots of saline were recalled from blood banks across North America. Immunohematology 18;3: 120–122.

Nondetection of the S antigen due to the presence of sodium hypochlorite

Immunohematology

{"article-title":"Nondetection of the S antigen due to the presence of sodium hypochlorite"}

Low concentrations of sodium hypochlorite (chlorine bleach) are known to destroy S antigen on intact fresh red blood cells (RBCs). Sodium hypochlorite is...

Nondetection of the S antigen due to the presence of sodium hypochlorite

Publicado en línea: 14 oct 2020

Páginas: 120 - 122

DOI: https://doi.org/10.21307/immunohematology-2019-528

Palabras clave
commercial saline, nondetection of S antigen, tube and microplate saline indirect antiglobulin tests

© 2002 A. Long et al., published by Sciendo

Nondetection of the S antigen due to the presence of sodium hypochlorite

Publicado en línea: 14 oct 2020

Páginas: 120 - 122

DOI: https://doi.org/10.21307/immunohematology-2019-528

Palabras clavecommercial saline, nondetection of S antigen, tube and microplate saline indirect antiglobulin tests

© 2002 A. Long et al., published by Sciendo

Palabras clave
commercial saline, nondetection of S antigen, tube and microplate saline indirect antiglobulin tests