<abstract xmlns="http://www.w3.org/1999/xhtml"><p>We report the case of a 62-year-old woman who developed an autoanti-D after cladribine treatment. In May 2000, the patient underwent splenectomy for a stage IV-B lymphoplasmocytic lymphoma. She was transfused with ABO- and Rh(D)-matched blood. A month later, she received chemotherapy with cladribine. In February 2001, blood grouping showed her to be AB, D+ and the direct antiglobulin test was positive for IgG. An autoanti-D was identified in the eluate. Genotypic analysis confirmed the Rh phenotype of the patient as ccDEe. No hemolysis was evident, as judged by the absence of anemia, a bilirubin of 15.7 <italic>μ</italic>mol/L, and lactic dehydrogenase of 412 IU/L. When an anti-D is identified in a D+ blood recipient, a passive transfer of anti-D, and an alloimmunization in a recipient with a weak D phenotype, should be ruled out. Finally, as in our case, an autoantibody is an additional possibility. <bold><italic>Immunohematology</italic> 2002;18:16–18</bold>.</p></abstract>

We report the case of a 62-year-old woman who developed an autoanti-D after cladribine treatment. In May 2000, the patient underwent splenectomy for a stage IV-B lymphoplasmocytic lymphoma. She was transfused with ABO- and Rh(D)-matched blood. A month later, she received chemotherapy with cladribine. In February 2001, blood grouping showed her to be AB, D+ and the direct antiglobulin test was positive for IgG. An autoanti-D was identified in the eluate. Genotypic analysis confirmed the Rh phenotype of the patient as ccDEe. No hemolysis was evident, as judged by the absence of anemia, a bilirubin of 15.7 μmol/L, and lactic dehydrogenase of 412 IU/L. When an anti-D is identified in a D+ blood recipient, a passive transfer of anti-D, and an alloimmunization in a recipient with a weak D phenotype, should be ruled out. Finally, as in our case, an autoantibody is an additional possibility. Immunohematology 2002;18:16–18.

Autoanti-D in a patient after cladribine treatment for lymphoplasmocytic lymphoma

Immunohematology

We report the case of a 62-year-old woman who developed an autoanti-D after cladribine treatment. In May 2000, the patient underwent splenectomy for a stage...

Autoanti-D in a patient after cladribine treatment for lymphoplasmocytic lymphoma

Publicado en línea: 14 oct 2020

Páginas: 16 - 18

DOI: https://doi.org/10.21307/immunohematology-2019-499

Palabras clave
autoantibody, direct antiglobulin test, cladribine, anti-D in a D+ recipient

© 2002 J. Cid et al., published by Sciendo

Autoanti-D in a patient after cladribine treatment for lymphoplasmocytic lymphoma

Publicado en línea: 14 oct 2020

Páginas: 16 - 18

DOI: https://doi.org/10.21307/immunohematology-2019-499

Palabras claveautoantibody, direct antiglobulin test, cladribine, anti-D in a D+ recipient

© 2002 J. Cid et al., published by Sciendo

Palabras clave
autoantibody, direct antiglobulin test, cladribine, anti-D in a D+ recipient