<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The Jk<sub>null</sub>(Jk-3) phenotype, attributable to null or silenced alleles, has predominantly been found in persons of Polynesian descent. With the increased use of molecular genotyping, many new silencing mutations have been identified in persons of other ethnic backgrounds. To date, only two <italic>JK</italic>null alleles have been reported in African Americans, <italic>JK*01N.04</italic>and <italic>JK*01N.05.</italic>A comparative study was undertaken to determine whether <italic>JK</italic>mutations were present in the regional African American population. Results of donor genotyping were compared with previously recorded results of serologic tests, and discrepant results were investigated. Although the two previously identified polymorphisms were not detected in the discrepant samples, a novel allele (191G>A) was identified and was assigned the ISBT number <italic>JK*02N.09.</italic>This study illustrates a limitation of using single-nucleotide polymorphisms for prediction of blood group antigens. <italic><bold>Immunohematology</bold></italic><bold>2013;29:145–148.</bold></p></abstract>

The Jknull(Jk-3) phenotype, attributable to null or silenced alleles, has predominantly been found in persons of Polynesian descent. With the increased use of molecular genotyping, many new silencing mutations have been identified in persons of other ethnic backgrounds. To date, only two JKnull alleles have been reported in African Americans, JK*01N.04and JK*01N.05.A comparative study was undertaken to determine whether JKmutations were present in the regional African American population. Results of donor genotyping were compared with previously recorded results of serologic tests, and discrepant results were investigated. Although the two previously identified polymorphisms were not detected in the discrepant samples, a novel allele (191G>A) was identified and was assigned the ISBT number JK*02N.09.This study illustrates a limitation of using single-nucleotide polymorphisms for prediction of blood group antigens. Immunohematology2013;29:145–148.

A novel <italic>JK</italic> null allele associated with typing discrepancies among African Americans

Immunohematology

A novel  null allele associated with typing discrepancies among African Americans

The Jknull(Jk-3) phenotype, attributable to null or silenced alleles, has predominantly been found in persons of Polynesian descent. With the increased use of...

A novel JK null allele associated with typing discrepancies among African Americans

Article Category: Report

Publicado en línea: 01 dic 2019

Páginas: 145 - 148

DOI: https://doi.org/10.21307/immunohematology-2019-138

© 2013 K.L. Billingsley, et al., published by Sciendo