Does tramadol have a place in the dental armamentarium? An atypical opioid in dental practice from the pharmacological perspective – Part II. Local tramadol administration within orofacial tissues

1 Pasternak M. Does tramadol have a place in the dental armamentarium? An atypical opioid in dental practice from the pharmacological perspective – Part I. General tramadol administration. Pomeranian J Life Sci 2023;69(1):30-8. doi: 10.21164/pomjlifesci.901. Search in Google Scholar

2 Barakat A. Revisiting tramadol: a multi-modal agent for pain management. CNS Drugs 2019;33(5):481-501. Search in Google Scholar

3 Danić P, Salarić I, Macan D. New findings on local tramadol use in oral surgery. Acta Stomatol Croat 2017;51(4):336-44. Search in Google Scholar

4 Farzam H, Farahani A, Tafkik A, Gorgin Karaji A, Mohajeri P, Rezaei M, et al. Antibacterial effect of tramadol against Staphylococcus aureus and Pseudomonas aeruginosa: an in vivo study. New Microbes New Infect 2018;24:42-6. doi: 10.1016/j.nmni.2018.04.001. Search in Google Scholar

5 Tamanai-Shacoori Z, Shacoori V, Jolivet-Gougeon A, Vo Van JM, Repère M, Donnio PY, et al. The antibacterial activity of tramadol against bacteria associated with infectious complications after local or regional anesthesia. Anesth Analg 2007;105(2):524-7. Search in Google Scholar

6 Al-Kurashy H, Ismail A, Al-windy S. Bacteriostatic effects of tramadol. In: Proceeding of 3rd scientific conference of the College of Science, University of Baghdad. Baghdad: University of Baghdad; 2009. p. 911-5. Search in Google Scholar

7 Al-Mashhadane FA, Mustafa EA, Taqa GA. Histological and antimicrobial effects of tramadol infiltration on incisional oral mucosal wound healing in rabbits. Iraqi J Veterinary Sci 2019;33(2):335-40. Search in Google Scholar

8 Hassabou NF, Elseweidy MM. Histopathological changes in submandibular gland and dorsal tongue of experimental rats due to prolonged tramadol intake focusing on novel modulatory effect of 10-dehydrogingerdione. Arch Oral Biol 2021;130:105223. doi: 10.1016/j.archoralbio.2021.105223. Search in Google Scholar

9 Bolaños DC, Guillén AP. Peripheral Tramadol in Dentistry: A New Use for an Old Drug Tramadol periférico en odontología: Un nuevo uso para un medicamento antiguo. Odovtos-International J Dental Sci 2016;18(2):10-4. Search in Google Scholar

10 Katsuki R, Fujita T, Koga A, Liu T, Nakatsuka T, Nakashima M, et al. Tramadol, but not its major metabolite (mono‐O‐demethyl tramadol) depresses compound action potentials in frog sciatic nerves. Br J Pharmacol 2006;149(3):319-27. Search in Google Scholar

11 Sousa AM, Ashmawi HA. Local analgesic effect of tramadol is not mediated by opioid receptors in early postoperative pain in rats. Rev Bras Anestesiol 2015;65(3):186-90. Search in Google Scholar

12 Akbay BK, Yildizbas S, Guclu E, Yilmaz S, Iskender A, Ozturk O. Analgesic efficacy of topical tramadol in the control of postoperative pain in children after tonsillectomy. J Anesth 2010;24(5):705-8. Search in Google Scholar

13 Tekelioglu UY, Apuhan T, Akkaya A, Demirhan A, Yildiz I, Simsek T, et al. Comparison of topical tramadol and ketamine in pain treatment after tonsillectomy. Pediatric Anaesth 2013;23(6):496-501. Search in Google Scholar

14 Gönül O, Satilmiş T, Ciftci A, Sipahi A, Garip H, Göker K. Comparison of the effects of topical ketamine and tramadol on postoperative pain after mandibular molar extraction. J Oral Maxillofac Surg 2015;73(11):2103-7. Search in Google Scholar

15 Farzam H, Yari M, Mohammadi G, Rahmatinejad M. A comparative study of tramadol and lidocaine gel on complications of orotracheal intubation. Anesth Pain Intens Care 2020;24(2):183-8. Search in Google Scholar

16 Rashwan S, Abdelmawgoud A, Badawy AA. Effect of tramadol gargle on postoperative sore throat: a double blinded randomized placebo controlled study. Egypt J Anesth 2014;30(3):235-9. Search in Google Scholar

17 Lamana SMS, Napimoga MH, Nascimento APC, Freitas FF, de Araujo DR, Quinteiro MS, et al. The anti-inflammatory effect of tramadol in the temporomandibular joint of rats. Eur J Pharmacol 2017;807:82-90. Search in Google Scholar

18 Sipahi A, Satilmis T, Basa S. Comparative study in patients with symptomatic internal derangements of the temporomandibular joint: analgesic outcomes of arthrocentesis with or without intra-articular morphine and tramadol. Br J Oral Maxillofac Surg 2015;53(4):316-20. Search in Google Scholar

19 Liu Y, Wu JS, Tang YL, Tang YJ, Fei W, Liang XH. Multiple treatment meta-analysis of intra-articular injection for temporomandibular osteoarthritis. J Oral Maxillofac Surg 2020;78(3):373.e1-e18. Search in Google Scholar

20 Rejab AF. Comparison of the intramuscular and sub-mucous postoperative analgesic effect of tramadol HCL after minor oral surgery. Int J Enhanc Res Sci Technol Eng 2014;3(5):122-9. Search in Google Scholar

21 Pozos-Guillén Ade J, Martínez-Rider R, Aguirre-Bañuelos P, Arellano-Guerrero A, Hoyo-Vadillo C, Pérez-Urizar J. Analgesic efficacy of tramadol by route of administration in a clinical model of pain. Proc West Pharmacol Soc 2005;48:61-4. Search in Google Scholar

22 Cillo JE. Peri-operative pain management in maxillofacial surgery. In: Ferneini EM, Bennett JD, editors. Perioperative assessment of the maxillofacial surgery patient. Cham: Springer; 2018. p.145-60. doi: 10.1007/978-3-319-58868-1_11. Search in Google Scholar

23 Pozos AJ, Martínez R, Aguirre P, Pérez J. Tramadol administered in a combination of routes for reducing pain after removal of an impacted mandibular third molar. J Oral Maxillofac Surg 2007;65(8):1633-9. Search in Google Scholar

24 Isiordia-Espinoza MA, Orozco-Solis M, Tobías-Azúa FJ, Méndez-Gutiérrez EP. Submucous tramadol increases the anesthetic efficacy of mepivacaine with epinephrine in inferior alveolar nerve block. Br J Oral Maxillofac Surg 2012;50(2):157-60. Search in Google Scholar

25 Isiordia-Espinoza MA, Pozos-Guillén AJ, Martínez-Rider R, Herrera-Abarca JE, Pérez-Urizar J. Preemptive analgesic effectiveness of oral ketorolac plus local tramadol after impacted mandibular third molar surgery. Med Oral Patol Oral Cir Bucal 2011;16(6):e776-80. doi: 10.4317/medoral.16854. Search in Google Scholar

26 Aksoy F, Ege B. The effect of pretreatment submucosal injections of tramadol and dexamethasone on post‐endodontic pain in mandibular molar teeth with symptomatic irreversible pulpitis: a randomized controlled clinical trial. Int Endod J 2020;53(2):176-85. Search in Google Scholar

27 De Pedro‐Muñoz A, Mena‐Álvarez J. The effect of preoperative submucosal administration of tramadol on the success rate of inferior alveolar nerve block on mandibular molars with symptomatic irreversible pulpitis: a randomized, double‐blind placebo‐controlled clinical trial. Int Endod J 2017;50(12):1134-42. Search in Google Scholar

28 Fanelli D, Weller G, Liu H. New serotonin-norepinephrine reuptake inhibitors and their anesthetic and analgesic considerations. Neurol Int 2021;13(4):497-509. doi: 10.3390/neurolint13040049. Search in Google Scholar

29 Shin HW, Ju BJ, Jang YK, You HS, Kang H, Park JY. Effect of tramadol as an adjuvant to local anesthetics for brachial plexus block: A systematic review and meta-analysis. PLoS One 2017;12(9):e0184649. Search in Google Scholar

30 Pozos AJ, Martinez R, Aguirre P, Perez J. The effects of tramadol added to articaine on anesthesia duration. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;102(5):614-7. Search in Google Scholar

31 Rodríguez‐Wong L, Pozos‐Guillen A, Silva‐Herzog D, Chavarría‐Bolaños D. Efficacy of mepivacaine – tramadol combination on the success of inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis: a randomized clinical trial. Int Endod J 2016;49(4):325-33. Search in Google Scholar

32 Pang WW, Mok MS, Chang DP, Huang MH. Local anesthetic effect of tramadol, metoclopramide, and lidocaine following intradermal injection. Reg Anesth Pain Med 1998;23(6):580-3. Search in Google Scholar

33 Jendi SK, Talathi A. Tramadol hydrochloride: an alternative to conventional local anesthetics for intraoral procedures – a preliminary study. J Oral Biol Craniofac Res 2019;9(1):111-4. Search in Google Scholar

34 Basu S, Mukherjee O, Sahu S, Banerjee R, Pachisia S, Biswas A. Tramadol HCL as an effective alternative to lignocaine HCL for extraction of tooth under supraperiosteal infiltration. Indian J Dent Sci 2021;13(3):175-7. Search in Google Scholar

35 Goel M, Sen P, Maturkar T, Latke S, Dehankar T. Effectiveness of tramadol compared to lignocaine as local anesthesia in the extraction of firm teeth: a randomized controlled trial. J Dent Anesth Pain Med 2021;21(3):245-52. Search in Google Scholar

36 Jendi SK, Syed AM, Badal S, Doiphode A, Chougule SS, Shaikh SA, et al. Comparison of local anaesthetic efficacy of tramadol versus lignocaine for extraction of tooth under supraperiosteal infiltration. J Maxillofac Oral Surg 2019;18(1):100-5. Search in Google Scholar

37 Ahmad Qureshi A, Mousa Bakri M. Comparative study of local anesthetic efficacy of 5% tramadol versus 2% lignocaine with 1:100,000 adrenaline for extraction of fully erupted maxillary 3rd molars using infiltration anesthesia. Saudi Dent J 2022;34(4):306-9. Search in Google Scholar

38 Siva Kalyan U, Satya Bhushan NVV, Chiang KC, Aparna D, Sunil T. Efficacy of tramadol hydrochloride as local anaesthetic and analgesic agent for extraction of maxillary teeth. J Clin Diagnostic Res 2020;14(6):ZC26-30. Search in Google Scholar

39 Shipton EA. Tramadol – present and future. Anaesth Intensive Care 2000;28(4):363-74. Search in Google Scholar

40 Al-Haideri YA. Comparison of local anesthetic efficacy of tramadol hydrochloride (with adrenaline) versus plain tramadol hydrochloride in the extraction of upper molar teeth. J Oral Maxillofac Surg 2013;71(12):2035-8. Search in Google Scholar

41 Kurdi MS, Ahmed Z, Mallikarjuna J. Tramadol-A local anesthetic with a difference. J Biomed Pharma Res 2014;3(2):49-54. Search in Google Scholar

42 Srivastava M, Singh bedi R, Aurora J, Markandey AS, Vishal G. Comparison of local anesthetic efficacy of tramadol hydrochloride (with adrenaline) versus lignocaine hydrochloride (with adrenaline) in non-complicated tooth extractions. Intern J Appl Dent Sci 2018;4(3):243-6. Search in Google Scholar

43 Ege B, Ege M, Koparal M, Alan H. Comparison of the anesthetic efficiency of lidocaine and tramadol hydrochloride in orthodontic extractions: a split-mouth, prospective, randomized, double-blind study. J Oral Maxillofac Surg 2020;78(1):52-62. doi: 10.1016/j.joms.2019.07.010. Search in Google Scholar

44 Panda NK, Mishra S, Lenka S, Mandal S, Agastya H, Rathor K. Local anesthetic efficacy of tramadol hydrochloride with adrenaline in the extraction of maxillary teeth. J Biomed Pharmaceutical Res 2021;10(4):28-37. Search in Google Scholar

45 Al-Haideri YA, Alsandook TA. A pilot double blinded clinical trial to compare between tramadol HCL and Lidocaine HCL as local anaesthesia amongst hospital-outpatient adult dental attendees Mosul-Iraqi. J Oral Dental Res 2013;23(1945):1-5. Search in Google Scholar

46 Mane RJ, Choi JJE, Sharpe-Davidson WF. Tramadol as a local anaesthetic agent in dentistry: a systematic review of local and systemic adverse effects. Saudi Dent J 2021;33(8):842-52. Search in Google Scholar

47 Pasternak M, Woroń J. Postępowanie w bólu poekstrakcyjnym. Ból 2020;21(1):47-52. Search in Google Scholar