<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Angiogenesis is the process that leads to the formation of new blood vessels. Under physiological conditions it occurs, inter alia, during corpus luteum formation and in some stages of the menstrual cycle. However, angiogenesis plays an essential role in many pathological conditions, particularly cancer. New blood vessel formation provides cancer cells with oxygen and essential nutrients, which stimulates tumor growth and facilitates its metastasis. Increasing evidence indicates that angiogenesis is regulated by microRNAs (miRNAs), which are small non-coding RNA molecules of 19–25 nucleotides. The main function of miRNAs is post-transcriptional regulation of gene expression, which controls many key biological processes, including cell proliferation, differentiation and migration. Endothelial miRNAs, known as angiomiRs, are presumably involved in tumor development and angiogenesis through regulation of pro- and antiangiogenic factors. To date, the miRNAs that stimulate angiogenesis are: miR-9, miR-27a, miR-30d, miR0-130b, miR-139, miR-146a, miR-150, miR-155, miR-200c, miR-296 and miR-558. Conversely, miRNAs that inhibit angiogenesis are: miR-145, miR-519c, miR-22, miR-20a, miR-92, miR-7b, miR-221, miR-222, miR-328 and miR-101.</p></abstract>

Angiogenesis is the process that leads to the formation of new blood vessels. Under physiological conditions it occurs, inter alia, during corpus luteum formation and in some stages of the menstrual cycle. However, angiogenesis plays an essential role in many pathological conditions, particularly cancer. New blood vessel formation provides cancer cells with oxygen and essential nutrients, which stimulates tumor growth and facilitates its metastasis. Increasing evidence indicates that angiogenesis is regulated by microRNAs (miRNAs), which are small non-coding RNA molecules of 19–25 nucleotides. The main function of miRNAs is post-transcriptional regulation of gene expression, which controls many key biological processes, including cell proliferation, differentiation and migration. Endothelial miRNAs, known as angiomiRs, are presumably involved in tumor development and angiogenesis through regulation of pro- and antiangiogenic factors. To date, the miRNAs that stimulate angiogenesis are: miR-9, miR-27a, miR-30d, miR0-130b, miR-139, miR-146a, miR-150, miR-155, miR-200c, miR-296 and miR-558. Conversely, miRNAs that inhibit angiogenesis are: miR-145, miR-519c, miR-22, miR-20a, miR-92, miR-7b, miR-221, miR-222, miR-328 and miR-101.

The role of microRNAs in angiogenesis

Pomeranian Medical University in Szczecin

Pomeranian Journal of Life Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"The role of microRNAs in angiogenesis"}

Angiogenesis is the process that leads to the formation of new blood vessels. Under physiological conditions it occurs, inter alia, during corpus luteum...

The role of microRNAs in angiogenesis

Publicado en línea: 23 dic 2019

Páginas: 37 - 41

DOI: https://doi.org/10.21164/pomjlifesci.631

Palabras clave
miRNA, angiogenesis, cancer, RNA, interference

© 2020 Joanna Bujak et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The role of microRNAs in angiogenesis

Publicado en línea: 23 dic 2019

Páginas: 37 - 41

DOI: https://doi.org/10.21164/pomjlifesci.631

Palabras clavemiRNA, angiogenesis, cancer, RNA, interference

© 2020 Joanna Bujak et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Palabras clave
miRNA, angiogenesis, cancer, RNA, interference