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Web-based Application for the Population Pharmacokinetic Service (WAPPS)'s impact on dosage selection: a single paediatric centre experience

Celia Kwan

Celia Kwan

Faculty of Medicine, University of British ColumbiaVancouver, Canada
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Kwan, Celia
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Mihir D. Bhatt

Mihir D. Bhatt

Department of Paediatrics, McMaster University, Hamilton Niagara Regional Hemophilia Program, McMaster Children's Hospital, Hamilton Health SciencesHamilton,
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Bhatt, Mihir D.
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Karen Strike

Karen Strike

Hamilton Niagara Regional Hemophilia Program, McMaster Children's Hospital, Hamilton Health Sciences, School of Rehabilitation Science, Faculty of Health Science, McMaster UniversityHamilton,
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Strike, Karen
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Kay Decker

Kay Decker

Hamilton Niagara Regional Hemophilia Program, McMaster Children's Hospital, Hamilton Health SciencesHamilton, Canada
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Decker, Kay
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Davide Matino

Davide Matino

Hamilton Niagara Regional Hemophilia Program, McMaster Children's Hospital, Hamilton Health Sciences, Department of Medicine, McMaster UniversityHamilton,
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Matino, Davide
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Anthony K.C. Chan

Anthony K.C. Chan

Department of Paediatrics, McMaster University, Hamilton Niagara Regional Hemophilia Program, McMaster Children's Hospital, Hamilton Health SciencesHamilton,
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Chan, Anthony K.C.
  
13 jul 2021
Web-based Application for the Population Pharmacokinetic Service (WAPPS)'s impact on dosage selection: a single paediatric centre experience's Cover Image
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Categoría del artículo: Clinical Research
Publicado en línea: 13 jul 2021
Páginas: 80 - 85
DOI: https://doi.org/10.17225/jhp00179
Palabras clave
© 2021 Celia Kwan et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
A recent study at McMaster Children's Hospital concludes that using WAPPS-generated pharmacokinetic data to personalise prophylaxis recommendations both validates clinical practice and supports patient-centred care
A recent study at McMaster Children's Hospital concludes that using WAPPS-generated pharmacokinetic data to personalise prophylaxis recommendations both validates clinical practice and supports patient-centred care

Figure 1

Change in hours per week where factor level is under 1% pre- and post-PK testing using WAPPS. Error bars represent the standard error.
Change in hours per week where factor level is under 1% pre- and post-PK testing using WAPPS. Error bars represent the standard error.

Data extracted from chart review

DATA EXTRACTED FROM CHART REVIEW
Patient demographics:

Age

Weight

Height

Baseline factor level
PK estimates calculated by the WAPPS tool
Prophylaxis regimen before PK testing
Prophylaxis regimen after PK testing
Reason for changing the prophylaxis regimen (if available)
Reason for not changing the prophylaxis regimen (if available)

Patient demographics

PATIENTS WHO HAVE CHANGED THEIR PROPHYLAXIS REGIMEN AFTER PK TESTING PATIENTS WHO HAVE NOT CHANGED THEIR PROPHYLAXIS REGIMEN AFTER PK TESTING
Age
Mean ± SD 10.61 ± 4.16 9.89 ± 3.26
(Minimum, Maximum) (2, 15) (3, 15)
Weight (kg)
Mean ± SD 45.72 ± 20.83 37.52 ± 14.53
(Minimum, Maximum) (14, 76.9) (14.5, 66.2)
Height (cm)
Mean ± SD 149.12 ± 31.89 140.99 ± 20.75
(Minimum, Maximum) (81, 184) (95.8, 175)

Changes to prophylaxis regimen after WAPPS

CHANGES TO PROPHYLAXIS REGIMEN
DOSAGE FREQUENCY DRUG NUMBER OF PATIENTS (N)
↑ ↓ — 8
↑ — — 1
↓ — — 1
↓ ↑ — 1
— ↑ — 1
— — Changed 1
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Temas de la revista:
Medicina, Ciencias médicas básicas, Ciencias médicas básicas, otros, Medicina Clínica, Medicina Clínica, otros, Farmacia, Farmacología
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