Cite

Fig. 1.

Flowchart of patient selection
Flowchart of patient selection

Fig. 2.

Proportion of LV responders in study population subdivided by tertiles of LAVI. LV reverse remodeling was defined as a relative reduction in LV end-systolic volume of ≥15%. LAVI – left atrial volume index
Proportion of LV responders in study population subdivided by tertiles of LAVI. LV reverse remodeling was defined as a relative reduction in LV end-systolic volume of ≥15%. LAVI – left atrial volume index

Fig. 3.

Correlation between relative reduction of LVESV and LAVI (Panel A) and LASr (Panel B). LVESV – left ventricular end-diastolic volume; LAVI – left atrial volume index; LASr – left atrial reservoir strain
Correlation between relative reduction of LVESV and LAVI (Panel A) and LASr (Panel B). LVESV – left ventricular end-diastolic volume; LAVI – left atrial volume index; LASr – left atrial reservoir strain

Cox proportional hazard regression analysis

Univariate analysis Multivariate analysis
Variables OR (95 CI) P-value OR P-value
Female 2.8 (1.1–7.1) 0.03
Ischemic etiology of heart failure 0.5 (0.2–1.2) 0.15
Electrocardiographic parameter
LBBB 6.0 (2.3–15.7) <0.01 4.2 (1.4–12.1) 0.009
QRSD >150 ms 3.0 (1.1–8.1) 0.03 4.2 (1.4–11.0) 0.029
Echocardiographic parameter
LVEDV (per 20 mL/m2) 0.9 (0.7–1.1) 0.35
LVEF (per 5%) 1.1 (0.9–1.5) 0.31
LAVI (per 10 mL) 0.6 (0.4–0.8) 0.001 0.6 (0.4–0.9) 0.012
LASr (per 10%) 2.5 (1.3–4.7) 0.005 -

Patient characteristics

Total group (n = 99) LV responders (n = 63) LV non-responders (n = 36) P-value
Demographics
    Age (yr) 70 (65–76) 70 (64–74) 71 (65–76) 0.64
    Male 63 (64%) 35 (56%) 28 (78%) 0.03
Medical history
    Ischemic heart failure 51 (52%) 29 (46%) 22 (61%) 0.21
    Hypertension 32 (32%) 23 (37%) 9 (25%) 0.27
    Diabetes Mellitus 23 (23%) 13 (21%) 10 (28%) 0.50
    COPD 7 (7%) 4 (6%) 3 (8%) 0.70
    Chronic kidney disease (MDRD <30) 4 (4%) 2 (3%) 2 (6%) 0.62
ECG characteristics
    LBBB 72 (73%) 54 (86%) 18 (50%) <0.001
    QRSD [ms] 166 ± 22 167 ± 16 163 ± 29 0.37
    QRSD >150 ms 78 (79%) 54 (86%) 24 (67%) 0.04
Laboratory parameters
    MDRD [mL/min/1.73 m2] 58 (45–61) 60 (50–61) 53 (43–60) 0.07
    NT-proBNP (pg/mL) 1438 (626–2791) 1226 (567–2009) 1776 (1184–3298) 0.04
Echocardiographic parameters
    LVEDV (mL/m2) 117 (107–138) 115 (100–136) 122 (109–142) 0.06
    LVESV (mL/m2) 87 (71–106) 84 (70–103) 89 (75–108) 0.25
    LVEF (%) 28 ± 8 28 ± 7 27 ± 8 0.32
    LAVI (mL/m2) 40 (31–52) 36 (28–47) 45 (37–60) <0.001
    LASr (%) 16 (10–21) 18 (12–22) 12 (8–17) <0.005
    Mitral regurgitation ≥ moderate (n, %) 34 (34%) 18 (29%) 16 (44%) 0.13
NYHA functional class
    II / III / IV 35/62/2 (35%/63%/2%) 25/37/1 (40%/59%/2%) 10/25/1 (28%/69%/3%) 0.37
Heart failure medication
    Beta-blocker 85 (86%) 55 (87%) 30 (83%) 0.77
    Renin-angiotensin system antagonist 89 (90%) 58 (92%) 31 (86%) 0.49
    Mineralocorticoid antagonist 36 (36%) 20 (32%) 16 (44%) 0.28
    Lis diuretics 59 (60%) 32 (51%) 27 (75%) 0.02
eISSN:
2451-070X
Idioma:
Inglés
Calendario de la edición:
4 veces al año
Temas de la revista:
Medicine, Basic Medical Science, other