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Level of evidence

A – data come from many meta-analyses, and/or it is unlikely that further research will change the credibility of effectiveness or accuracy of the method
B – data come from individual large non-randomized trials (meta-analysis, prospective cohort study), and/or further testing may have a significant impact on the credibility of effectiveness or accuracy of the method
C – agreed expert opinion and/or data from small studies, retrospective studies, registers, case series, or case reports, and/or it is very likely that further testing will have an important impact on the credibility of effectiveness or accuracy of the method. Any estimation of the effects or accuracy of the method is very uncertain (very low)

Experts’ opinion

1 For ≥ 80%
2 Against ≤ 50%
0 Undecided 51–79%

Results of data credibility (level of evidence) and expert opinions for individual statements. N/A – not applicable

The number of the statement Level of evidence Expert opinion Strength of recommendations
A, B, C I round II round III round
1 A >80% >80% >80% A1
2 A >80% >80% >80% A1
3 A >80% >80% >80% A1
4 A >80% >80% >80% A1
5 A >80% >80% >80% A1
6 A >80% >80% >80% A1
7 A >80% >80% >80% A1
8 A >80% >80% >80% A1
9 A >80% >80% >80% A1
10 A >80% >80% >80% A1
11 A >80% >80% >80% A1
12 A >80% >80% >80% A1
13 A >80% >80% >80% A1
14 A >80% >80% >80% A1
15 A >80% >80% >80% A1
16 A >80% >80% >80% A1
17 A >80% >80% >80% A1
18 A >80% >80% >80% A1
19 A >80% >80% >80% A1
20 A >80% >80% >80% A1
21 A >80% >80% >80% A1
22 A >80% >80% >80% A1
23 A >80% >80% >80% A1
24 A >80% >80% >80% A1
25 A >80% >80% >80% A1
26 A >80% >80% >80% A1
27 A >80% >80% >80% A1
28 C >80% >80% >80% C1
29 A >80% >80% >80% A1
30 A >80% >80% >80% A1
31 A >50% and <80% >80% >80% A1
32 N/A >80% >80% >80% N/A
33 N/A >80% >80% >80% N/A
34 N/A >80% >80% >80% N/A
35 N/A >80% >80% >80% N/A
36 N/A >80% >80% >80% N/A
37 N/A >80% >80% >80% N/A
38 N/A >80% >80% >80% N/A

Strength of recommendations

Opinion of the authors on the balance of beneficial and adverse effects of the intervention Level of evidence Strength of recommendation Strength of recommendation – practical implications
1 A 1A strong recommendation; a given procedure should be widely used as long as there are no strong contraindications
1 B 1B strong recommendation, but with less degree of certainty; probably right in most individual cases
1 C 1C the average strength of recommendation; the recommendation may change after obtaining more reliable data; probably right
2 A 2A the average strength of recommendation; the decision on its adoption is a matter of choice and may depend on local and individual conditions; intervention does not have to be used
2 B 2B weak recommendation; alternative conduct can be just as good or better
2 C 2C weak recommendation; alternative treatment is probably equally acceptable
eISSN:
2451-070X
Idioma:
Inglés
Calendario de la edición:
4 veces al año
Temas de la revista:
Medicine, Basic Medical Science, other