<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_sjph-2017-0033_s_009_w2aab3b7b8b1b6b1aab1c18b1Aa"><h3>Introduction</h3><p>Hypoglycaemia is the major barrier for glycaemic target achievement in patients treated with insulin. The aim of the present study was to investigate real-world incidence and predictors of hypoglycaemia in insulin-treated patients.</p></sec><sec id="j_sjph-2017-0033_s_010_w2aab3b7b8b1b6b1aab1c18b2Aa"><h3>Methods</h3><p>More than 300 consecutive patients with type 1 or type 2 diabetes treated with insulin were enrolled during regular out-patient visits from 36 diabetes practices throughout the whole country. They completed a comprehensive questionnaire on hypoglycaemia knowledge, awareness, and incidence in the last month and last six months. In addition, in the prospective part, patients recorded incidence of hypoglycaemic events using a special diary prospectively on a daily basis, through 4 weeks.</p></sec><sec id="j_sjph-2017-0033_s_011_w2aab3b7b8b1b6b1aab1c18b3Aa"><h3>Results</h3><p>At least one hypoglycaemic event was self-reported in 84.1%, and 56.4% of patients with type 1 and type 2 diabetes, respectively, during the prospective period of 4 weeks. 43.4% and 26.2% of patients with type 1 and type 2 diabetes, respectively, experienced a nocturnal hypoglycaemic event. In the same time-period, severe hypoglycaemia was experienced by 15.9% and 7.1% of patients with type 1 and type 2 diabetes, respectively. Lower glycated haemoglobin was not a significant predictor of hypoglycaemia.</p></sec><sec id="j_sjph-2017-0033_s_012_w2aab3b7b8b1b6b1aab1c18b4Aa"><h3>Conclusions</h3><p>Rates of self-reported hypoglycaemia in patients treated with insulin in the largest and most comprehensive study in Slovenia so far are higher than reported from randomised control trials, but comparable to data from observational studies. Hypoglycaemia incidence was high even with high glycated haemoglobin values.</p></sec></abstract>

IntroductionHypoglycaemia is the major barrier for glycaemic target achievement in patients treated with insulin. The aim of the present study was to investigate real-world incidence and predictors of hypoglycaemia in insulin-treated patients.MethodsMore than 300 consecutive patients with type 1 or type 2 diabetes treated with insulin were enrolled during regular out-patient visits from 36 diabetes practices throughout the whole country. They completed a comprehensive questionnaire on hypoglycaemia knowledge, awareness, and incidence in the last month and last six months. In addition, in the prospective part, patients recorded incidence of hypoglycaemic events using a special diary prospectively on a daily basis, through 4 weeks.ResultsAt least one hypoglycaemic event was self-reported in 84.1%, and 56.4% of patients with type 1 and type 2 diabetes, respectively, during the prospective period of 4 weeks. 43.4% and 26.2% of patients with type 1 and type 2 diabetes, respectively, experienced a nocturnal hypoglycaemic event. In the same time-period, severe hypoglycaemia was experienced by 15.9% and 7.1% of patients with type 1 and type 2 diabetes, respectively. Lower glycated haemoglobin was not a significant predictor of hypoglycaemia.ConclusionsRates of self-reported hypoglycaemia in patients treated with insulin in the largest and most comprehensive study in Slovenia so far are higher than reported from randomised control trials, but comparable to data from observational studies. Hypoglycaemia incidence was high even with high glycated haemoglobin values.

Self-reported hypoglycaemia in patients treated with insulin: A large Slovenian retrospectively-prospective study

Slovenian Journal of Public Health

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

HIPOGLIKEMIJE PRI BOLNIKIH, ZDRAVLJENIH Z INSULINOM: VELIKA SLOVENSKA RETROSPEKTIVNOPROSPEKTIVNA RAZISKAVA

IntroductionHypoglycaemia is the major barrier for glycaemic target achievement in patients treated with insulin. The aim of the present study was to...

Self-reported hypoglycaemia in patients treated with insulin: A large Slovenian retrospectively-prospective study

Article Category: Original scientific article

Publicado en línea: 09 oct 2017

Páginas: 244 - 250

Recibido: 14 feb 2017

Aceptado: 10 ago 2017

DOI: https://doi.org/10.1515/sjph-2017-0033

Palabras clave
hypoglycaemia, type 1 diabetes, type 2 diabetes, insulin treatment, Slovenia

© 2017 National Institute of Public Health, Slovenia

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Self-reported hypoglycaemia in patients treated with insulin: A large Slovenian retrospectively-prospective study

Article Category: Original scientific article

Publicado en línea: 09 oct 2017

Páginas: 244 - 250

Recibido: 14 feb 2017

Aceptado: 10 ago 2017

DOI: https://doi.org/10.1515/sjph-2017-0033

Palabras clavehypoglycaemia, type 1 diabetes, type 2 diabetes, insulin treatment, Slovenia

© 2017 National Institute of Public Health, Slovenia

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Palabras clave
hypoglycaemia, type 1 diabetes, type 2 diabetes, insulin treatment, Slovenia