<abstract xmlns="http://www.w3.org/1999/xhtml"><p> B cells play a dual role in the pathogenesis of autoimmune diseases. In experimental autoimmune encephalomyelitis (EAE), an experimental model for multiple sclerosis, B cells contribute to disease progression, while their regulatory role predominates in the initial phases of disease development. Several studies have identified different subsets of regulatory B cells, mostly in the spleen, which are all sources of IL-10. However, peritoneal regulatory B cells are also important producers of IL-10, can migrate towards inflammatory stimuli, and could have an immunoregulatory function. As we have observed expansion of regulatory B cells in the peritoneum of resistant mice after EAE induction, herein we discuss the regulatory roles of B cells in EAE pathogenesis and the possible role of peritoneal regulatory B cells in resistance to EAE induction.</p></abstract>

B cells play a dual role in the pathogenesis of autoimmune diseases. In experimental autoimmune encephalomyelitis (EAE), an experimental model for multiple sclerosis, B cells contribute to disease progression, while their regulatory role predominates in the initial phases of disease development. Several studies have identified different subsets of regulatory B cells, mostly in the spleen, which are all sources of IL-10. However, peritoneal regulatory B cells are also important producers of IL-10, can migrate towards inflammatory stimuli, and could have an immunoregulatory function. As we have observed expansion of regulatory B cells in the peritoneum of resistant mice after EAE induction, herein we discuss the regulatory roles of B cells in EAE pathogenesis and the possible role of peritoneal regulatory B cells in resistance to EAE induction.

Regulatory Role of Peritoneal B Cells in EAE

Centar za molekulsku medicinu i istraživanje matičnih ćelija, Fakultet medicinskih nauka, Univerzitet u Kragujevcu, Kragujevac, Srbija

Katedra za patofi ziologiju, Fakultet medicinskih nauka, Univerzitet u Kragujevcu, Kragujevac, Srbija

Katedra za histologiju, Fakutet medicinskih nauka, Univerzitet u Kragujevcu, Kragujevac, Srbija

Center for Molecular Medicine and Stem Cell Research,Faculty of Medicine University of Kragujevac Svetozara Markovica 69, 34000 Kragujevac, Serbia

Center for Molecular Medicine and Stem Cell Research, Faculty of Medicine University of Kragujevac, Kragujevac, Serbia

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Regulatory Role of Peritoneal B Cells in EAE"}

B cells play a dual role in the pathogenesis of autoimmune diseases. In experimental autoimmune encephalomyelitis (EAE), an experimental model for multiple...

Regulatory Role of Peritoneal B Cells in EAE

Publicado en línea: 10 jun 2016

Páginas: 87 - 92

Recibido: 02 sept 2015

Aceptado: 08 sept 2015

DOI: https://doi.org/10.1515/sjecr-2015-0048

Palabras clave
multiple sclerosis, EAE, B cells, peritoneal regulatory B cells

© 2016

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Regulatory Role of Peritoneal B Cells in EAE

Publicado en línea: 10 jun 2016

Páginas: 87 - 92

Recibido: 02 sept 2015

Aceptado: 08 sept 2015

DOI: https://doi.org/10.1515/sjecr-2015-0048

Palabras clavemultiple sclerosis, EAE, B cells, peritoneal regulatory B cells

© 2016

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Palabras clave
multiple sclerosis, EAE, B cells, peritoneal regulatory B cells