<abstract xmlns="http://www.w3.org/1999/xhtml">Verrucous carcinoma (VC) is a rare variant of a well-differentiated squamous cell carcinoma (SCC) with a low grade of malignancy. Epithelioma cuniculatum (EC) is a subtype of VC, usually found on the sole of the foot.Two patients, a 55-year-old female, and a 77-year-old male, with VC were treated at the Clinic of Dermatology and Venereology, Clinical Center of Serbia, from 2002 to 2011. Both patients presented with a tumor on the foot. Incisional biopsies showed a well differentiated squamous cell carcinoma. Foot x-rays showed bone involvement in one case. One patient underwent surgical amputation of the lower extremity, while the other had a partial amputation of the affected foot.In the initial stage of the disease, it is difficult to distinguish pseudoepitheliomatous hyperplasia from verrucous carcinoma. The superficial biopsy of EC lesion may mislead to a histopathological diagnosis of warts or condylomas. Multiple deep biopsies are necessary for accurate and timely diagnosis of verrucous carcinoma.</abstract>

Verrucous carcinoma (VC) is a rare variant of a well-differentiated squamous cell carcinoma (SCC) with a low grade of malignancy. Epithelioma cuniculatum (EC) is a subtype of VC, usually found on the sole of the foot.Two patients, a 55-year-old female, and a 77-year-old male, with VC were treated at the Clinic of Dermatology and Venereology, Clinical Center of Serbia, from 2002 to 2011. Both patients presented with a tumor on the foot. Incisional biopsies showed a well differentiated squamous cell carcinoma. Foot x-rays showed bone involvement in one case. One patient underwent surgical amputation of the lower extremity, while the other had a partial amputation of the affected foot.In the initial stage of the disease, it is difficult to distinguish pseudoepitheliomatous hyperplasia from verrucous carcinoma. The superficial biopsy of EC lesion may mislead to a histopathological diagnosis of warts or condylomas. Multiple deep biopsies are necessary for accurate and timely diagnosis of verrucous carcinoma.

Verrucous Carcinoma of the Foot - Report of Two Cases

Clinic of Dermatology and Venereology, Clinical Center of Serbia, Belgrade,

School of Medicine, University of Belgrade, Belgrade,

Serbian Journal of Dermatology and Venereology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Verrucous Carcinoma of the Foot - Report of Two Cases"}

Verrucous carcinoma (VC) is a rare variant of a well-differentiated squamous cell carcinoma (SCC) with a low grade of malignancy. Epithelioma cuniculatum (EC)...

Verrucous Carcinoma of the Foot - Report of Two Cases

Publicado en línea: 20 mar 2017

Páginas: 155 - 160

DOI: https://doi.org/10.1515/sjdv-2016-0013

Palabras clave
Carcinoma, Verrucous, Foot Diseases, Diagnosis, Skin Neoplasms, Biopsy, Amputation

© 2016 Jovan Lalošević et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Verrucous Carcinoma of the Foot - Report of Two Cases

Publicado en línea: 20 mar 2017

Páginas: 155 - 160

DOI: https://doi.org/10.1515/sjdv-2016-0013

Palabras claveCarcinoma, Verrucous, Foot Diseases, Diagnosis, Skin Neoplasms, Biopsy, Amputation

© 2016 Jovan Lalošević et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Palabras clave
Carcinoma, Verrucous, Foot Diseases, Diagnosis, Skin Neoplasms, Biopsy, Amputation