<abstract xmlns="http://www.w3.org/1999/xhtml"> The relationship between the kidney and other organs is notable. The bestknown is the relation with the cardiovascular system. Relationships with other organs are less studied, although their involvement sometimes dominates the clinical picture and the outcome of disease.The paper analyzes the kidney-liver relationship, namely chronic kidney disease and chronic liver disease from an immune viewpoint. The immune system operates as a unitary whole. There is an interdependence between the immune system of the liver, considered a lymphoid organ, and the kidney, whose participation in immune processes is well-known.The most important chronic liver diseases are viral hepatitis B and C. Infection with these viruses can lead to renal involvement, producing mainly glomerular disease.At the same time, secondary glomerulonephritis can cause an unfavorable outcome of the primary disease.The relationship between chronic liver disease and chronic kidney disease during chronic B and C hepatitis occurs via circulating immune complexes or complexes formed in situ. Cell-mediated immunity is also involved.The antiviral treatment of B and C hepatitis is also aimed at secondary glomerular disease.The participation of immune mechanisms raises the question of administering immunomodulating medication, a type of medication that influences viral replication - this is why it is associated with antiviral medication. Other two chronic liver diseases, namely liver cirrhosis, in which the main mechanism is a toxic one, and non-alcoholic steatohepatitis can produce via immune mechanisms glomerular involvement.In its turn, chronic kidney disease in advanced stages causes lipid metabolism disturbances with hypertriglyceridemia, which can influence fatty loading of the liver in the above-mentioned liver diseases.One can speak about a cross-talk between the liver and the kidney, in which immune mechanisms play an important role.</abstract>

The relationship between the kidney and other organs is notable. The bestknown is the relation with the cardiovascular system. Relationships with other organs are less studied, although their involvement sometimes dominates the clinical picture and the outcome of disease.The paper analyzes the kidney-liver relationship, namely chronic kidney disease and chronic liver disease from an immune viewpoint. The immune system operates as a unitary whole. There is an interdependence between the immune system of the liver, considered a lymphoid organ, and the kidney, whose participation in immune processes is well-known.The most important chronic liver diseases are viral hepatitis B and C. Infection with these viruses can lead to renal involvement, producing mainly glomerular disease.At the same time, secondary glomerulonephritis can cause an unfavorable outcome of the primary disease.The relationship between chronic liver disease and chronic kidney disease during chronic B and C hepatitis occurs via circulating immune complexes or complexes formed in situ. Cell-mediated immunity is also involved.The antiviral treatment of B and C hepatitis is also aimed at secondary glomerular disease.The participation of immune mechanisms raises the question of administering immunomodulating medication, a type of medication that influences viral replication - this is why it is associated with antiviral medication. Other two chronic liver diseases, namely liver cirrhosis, in which the main mechanism is a toxic one, and non-alcoholic steatohepatitis can produce via immune mechanisms glomerular involvement.In its turn, chronic kidney disease in advanced stages causes lipid metabolism disturbances with hypertriglyceridemia, which can influence fatty loading of the liver in the above-mentioned liver diseases.One can speak about a cross-talk between the liver and the kidney, in which immune mechanisms play an important role.

Chronic Kidney Disease – Chronic Liver Disease. An Immunologic Cross-talk

Romanian Academy of Medical Sciences, Emergency Clinical County Hospital, Timişoara , Romania

“V. Babeş” University of Medicine and Pharmacy, Emergency Clinical County Hospital, Timişoara, Romania

Romanian Academy of Medical Sciences, “V. Babeş” University of Medicine and Pharmacy, Emergency Clinical County Hospital, Timişoara, Romania

“V. Babeş” University of Medicine and Pharmacy, Clinic of Infectious Diseases, Timişoara, Romania

Emergency Clinical County Hospital, Timişoara , Romania

Romanian Journal of Internal Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Chronic Kidney Disease \u2013 Chronic Liver Disease. An Immunologic Cross-talk"}

The relationship between the kidney and other organs is notable. The bestknown is the relation with the cardiovascular system. Relationships with other organs...

Chronic Kidney Disease – Chronic Liver Disease. An Immunologic Cross-talk

Publicado en línea: 07 oct 2015

Páginas: 3 - 12

Recibido: 22 ene 2015

DOI: https://doi.org/10.1515/rjim-2015-0001

Palabras clave
chronic kidney desease, chronic liver desease, immune complexes

© 2015

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Chronic Kidney Disease – Chronic Liver Disease. An Immunologic Cross-talk

Publicado en línea: 07 oct 2015

Páginas: 3 - 12

Recibido: 22 ene 2015

DOI: https://doi.org/10.1515/rjim-2015-0001

Palabras clavechronic kidney desease, chronic liver desease, immune complexes

© 2015

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Palabras clave
chronic kidney desease, chronic liver desease, immune complexes