Optimal planning strategy among various arc arrangements for prostate stereotactic body radiotherapy with volumetric modulated arc therapy technique

	Avg ±SD (range)

	1FA	1PA	2FA	2PA
CTV coverage
D_50% (Gy)	44.9±0.4	44.6±0.5	44.5±0.5	44.4±0.3
D_50% (Gy)	(44.4-45.4)	(44.1-45.1)	(44.0-45.3)	(44.0-44.7)
D_5% (Gy)	46.0±0.1	45.9±0.1	45.9±0.1	45.8±0.2
D_5% (Gy)	(45.9-46.1)	(45.7-46.0)	(45.8-46.0)	(45.7-45.9)
D_95% (Gy)	43.5±0.5	43.1±0.4	43.1±0.6	42.8±0.2
D_95% (Gy)	(43.0-44.2)	(42.8-43.5)	(42.6-43.9)	(42.7-43.1)
V_100% (%)	98.4±1.8	97.9±0.0	97.8±3.8	97.6±2.0
V_100% (%)	(95.5-100.0)	(95.0-99.8)	(95.2-100.0)	(94.2-99.9)
PTV coverage
D_mean	44.3±0.2	44.2±0.1	44.1±0.3	44.3±0.1
D_mean	(44.2-44.6)	(44.0-44.4)	(44.0-44.6)	(44.2-44.5)
D_max	48.8±0.8	49.5±0.9	48.5±1.1	49.0±1.4
D_max	(47.8-49.8)	(48.4-50.5)	(47.2-50.0)	(47.4-50.5)
D_min	33.0±0.4	32.3±0.0	32.8±0.8	33.7±0.3
D_min	(32.4-33.2)	(31.9-33.7)	(32.1-33.9)	(33.4-34.1)
D_50% (Gy)	44.6±0.3	44.5±0.2	44.4±0.4	44.5±0.2
D_50% (Gy)	(44.2-45.0)	(44.3-44.8)	(44.1-45.0)	(44.3-44.8)
D_5% (Gy)	46.1±0.2	46.1±0.1	46.1±0.2	46.0±0.1
D_5% (Gy)	(45.9-46.3)	(45.9-46.2)	(45.9-46.3)	(45.9-46.2)
D_95% (Gy)	41.5±0.3	41.4±0.2	41.3±0.3	41.7±0.1
D_95% (Gy)	(41.1-41.8)	(41.2-41.8)	(41.0-41.7)	(41.6-41.9)
V_100% (%)	87.5±1.9	86.6±1.2	87.7±1.5	88.1±1.0
V_100% (%)	(85.1-90.2)	(85.0-87.8)	(85.8-89.3)	(87.1-89.9)
Conformity	1.05±0.00	1.04±0.01	1.03±0.01	1.05±0.01
index	(1.02-1.03)	(1.02-1.04)	(1.02-1.04)	(1.02-1.03)
Conformation	0.91±0.01	0.91±0.01	0.91±0.01	0.91±0.01
number	(0.90-0.92)	(0.09-0.92)	(0.91-0.92)	(0.90-0.93)
Homogeneity	0.10±0.01	0.11±0.00	0.11±0.01	0.10±0.00
index	(0.09-0.12)	(0.10-0.11)	(0.10-0.12)	(0.09-0.10)

Dose volume constraints adopted for planning study_

Volume	Rectum	Bladder	Femoral heads
	V_42.7_{Gy (100%)} < 5%	V_42.7_Gy(100%) < 10%	V_29.9_{Gy (70%)} < 50%
	V_38.4_{Gy (90%)} < 15%	V_34.7_{Gy (81%)} < 25%	D_max <29.9 Gy
Constraints	V_32.0_{Gy (75%)} < 35%	V_{29.9 Gy(70%)} < 50%
	V_28.0_{Gy (65%)} < 45%
	V_{_24.8_{Gy (58%)} < 70%}
	V_20.0_{Gy (47%)} < 80%

Average monitor unit and delivery time for prostate SBRT-VMAT plans using four arc arrangements_

Beams	1FA (Mean ± SD)	1PA (Mean ± SD)	2FA (Mean ± SD)	2PA (Mean ± SD)
MU	1575±63	1627±56	1646±97	1660±98

Delivery time (min)	1.01±0.02	0.69±0.01	2.00±0.01	1.36±0.02

TCP of prostate tumor and NTCP of OARs for four arc arrangement plans_

Beams	1FA (Mean±SD)	1PA (Mean±SD)	2FA (Mean±SD)	2PA (Mean±SD)
TCP (%)
Prostate	93.35±0.08	99.28±0.06	93.32±0.08	93.36±0.08
NTCP (%)
Rectum	0.44±0.23	0.61±0.21	0.40±0.23	0.56±0.22
Bladder	0.01±0.02	0.01±0.03	0.00±0.01	0.00±0.02
LT Femur	0.00±0.00	0.00±0.00	0.00±0.00	0.00±0.00
RT Femur	0.00±0.00	0.00±0.00	0.00±0.00	0.00±0.00

Parameters used to calculated Niemierko’s EUD-based TCP and NTCP_

Tissue	100%dpf (Gy)	Fraction (#)	α	γ₅₀	TD₅₀ (Gy)	TCD₅₀ (Gy)	dpf (Gy)	α/β (Gy)
Prostate	6.1	7	-10	1.0		28.34	2	1.20
Rectum	6.1	7	8.33	4	80		2	3.90
Bladder	6.1	7	2	4	80		2	8.00
Femur	6.1	7	4	4	65		2	0.85

Dosimetric results for organs at risk in prostate SABR-VMAT plans using four arc arrangements_

	Avg SD (range)

	IFA	1PA	2FA	2PA
Organs at risk
Rectum D_mean (Gy)	25.2±1.7	23.3±2.0	23.6±1.8	23.4±1.9
Rectum D_mean (Gy)	(23.1-27.2)	(21.4-25.8)	(21.3-26.0)	(21.3-26.4)
Rectum D_2% (Gy)	44.2±0.3	44.6±0.4	44.1±0.4	44.5±0.2
Rectum D_2% (Gy)	(43.7-44.5)	(44.0-45.1)	(43.8-44.7)	(44.3-44.9)
Rectum V_95% (%)	9.0±1.4	10.1±1.3	8.3±1.3	9.8±1.5
Rectum V_95% (%)	(6.6-10.3)	(8.1-11.5)	(7.0-10.2)	(7.6-11.6)
Rectum V_80% (%)	19.1±3.0	19.7±3.2	18.0±2.8	19.4±3.4
Rectum V_80% (%)	(15.1-23.2)	(15.2-23.8)	(15.2-21.9)	(14.8-24.3)
Rectum V_50% (%)	71.0±8.8	53.9±9.4	60.0±11.1	54.1±9.0
Rectum V_50% (%)	(61.1-80.1)	(41.9-63.7)	(46.9-77.4)	(42.5-66.7)
Rectum V_20% (%)	90.2±2.5	90.0±2.7	89.6±3.0	90.0±2.8
Rectum V_20% (%)	(87.7-93.4)	(87.1-94.1)	(85.6-93.5)	(87.3-94.0)
Bladder D_mean (Gy)	19.0±6.9	18.7±7.1	18.5±6.1	18.3±6.9
Bladder D_mean (Gy)	(13.4-31.1)	(13.2-31.0)	(15.7-29.0)	(12.9-30.4)
Bladder D_2% (Gy)	45.6±0.2	45.6±0.2	45.5±0.3	45.6±0.4
Bladder D_2% (Gy)	(45.5-45.8)	(45.3-45.9)	(45.0-45.8)	(45.3-46.4)
Bladder V_95% (%)	21.2±11.1	21.4±11.1	20.9±10.5	21.4±11.3
Bladder V_95% (%)	(10.5-39.3)	(10.6-39.4)	(10.3-37.7)	(10.7-39.9)
Bladder V_80% (%)	25.6±11.9	26.2±11.9	25.7±11.1	26.0±12.0
Bladder V_80% (%)	(16.6-46.4)	(16.5-46.3)	(16.6-44.6)	(16.3-46.2)
Bladder V_50% (%)	40.4±13.6	38.6±12.6	39.5±12.4	38.2±12.9
Bladder V_50% (%)	(29.4-64.1)	(28.5-60.5)	(29.2-60.7)	(27.5-60.6)
Bladder V_20% (%)	54.4±17.0	52.5±16.1	54.1±17.4	52.1±16.1
Bladder V_20% (%)	(37.2-79.1)	(36.4-76.5)	(37.0-79.4)	(36.2-76.1)
Left femoral head	12.8±1.8	18.7±2.3	12.7±2.4	13.9±1.4
D_mean (Gy)	(10.5-15.1)	(16.9-22.7)	(9.3-14.9)	(11.7-15.3)
Left femoral head	19.7±2.2	23.5±4.4	18.3±3.0	20.1±2.0
D_2% (Gy)	(16.9-21.8)	(15.6-26.1)	(13.4-20.7)	(16.7-21.8)
Right femoral	10.8±0.9	13.3±2.5	12.4±1.7	13.7±2.1
head D_mean (Gy)	(9.2-11.3)	(9.2-15.5)	(10.5-14.2)	(10.7-16.5)
Right femoral	16.4±1.3	20.6±3.7	18.1±1.9	19.7±2.3
head D_2% (Gy)	(14.3-18.0)	(14.3-23.6)	(15.8-20.1)	(16.2-22.5)

Idioma:: Inglés

Calendario de la edición:: 4 veces al año
Temas de la revista:: Medicina, Medicina Clínica, Medicina Interna, Hematología, oncología, Radiología

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Optimal planning strategy among various arc arrangements for prostate stereotactic body radiotherapy with volumetric modulated arc therapy technique

Sang Won Kang

Jin Beom Chung

Jae Sung Kim

In Ah Kim

Keun Yong Eom

Changhoon Song

Jeong Woo Lee

Jin Young Kim

Tae Suk Suh

Categoría del artículo: Research Article

Publicado en línea: 15 ene 2017

Páginas: 112 - 120

Recibido: 19 jul 2016

Aceptado: 25 oct 2016

DOI: https://doi.org/10.1515/raon-2017-0005

Palabras clavestereotactic body radiotherapy, volumetric modulated arc therapy, prostate cancer, arc arrangement, dosimetric and biological metrics

© 2017 Sang Won Kang, Jin Beom Chung, Jae Sung Kim, In Ah Kim, Keun Yong Eom, Changhoon Song, Jeong Woo Lee, Jin Young Kim, Tae Suk Suh

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Dosimetric results for target volumes in prostate SABR-VMAT plans using four arc arrangements_

Dose volume constraints adopted for planning study_

Average monitor unit and delivery time for prostate SBRT-VMAT plans using four arc arrangements_

TCP of prostate tumor and NTCP of OARs for four arc arrangement plans_

Parameters used to calculated Niemierko’s EUD-based TCP and NTCP_

Dosimetric results for organs at risk in prostate SABR-VMAT plans using four arc arrangements_

Palabras clave
stereotactic body radiotherapy, volumetric modulated arc therapy, prostate cancer, arc arrangement, dosimetric and biological metrics