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Treatment-related cardiovascular toxicity in long-term survivors of testicular cancer


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Risk for coronary artery disease in testicular cancer survivors regarding to different treatment modalities

Author (year)NPeriod of treatmentMedian follow up (range), in yearsAge at diagnosis (range)Age at follow-up (range)Risk for CAD (CI 95 %)Treatment ModalitiesNote
Meinardi et al.17 (2000)87Before 1987

All patients treated with cisplatin based chemotherapy before 1987.

14 (10 to 20)27 (17-36)42 (30-50)SIR=7.1 (1.9 to 18.3)ChTAge adjusted results. Older than 50years at follow-up were excluded
Huddart et al.24 (2003)9921982-199210.2 (0 to 20.3)31.7 (10-82)44 (23-78)RR=1.00 (reference)RR=2.59 (1.15 to 5.84)RR=2.40 (1.04 to 5.45)RR=2.78 (1.09 to 7.07)SurveillanceChTChT RTChT and RTAge adjusted results. Only 8.3 %of RT treated patients had alsomed. RT
Van der Belt-Dusebuot etal.11 (2006)23391965-199518.4 (5 to 38.4)38.3

Age for seminoma patients.

(n.r.)28.1

Age for nonseminoma patients.

(n.r.)
59.8

Age for seminoma patients.

(n.r.)50.4

Age for nonseminoma patients.

(n.r.)
SIR=0.94 (0.61 to 1.39)SIR=1.35 (0.97 to 1.83)SIR=1.07 (0.92 to 1.23)SIR=2.48 (1.77 to 3.37)SIR=0.92 (0.77 to 1.08)SIR=2.97 (1.73 to 4.77)SIR=1.83 (1.08 to 2.90)SurveillanceChTRTRT – medRT – subdiaRT – med. + ChTRT – subdia. + ChTPatients with CAD before orwithin 5 years from diagnosis wereexcluded
Haughnes et al.12 (2010)9901980-199419 (13 to 28)31 (15-53)51 (31-69)HR=1.0 (reference)HR=2.0 (0.64 to 6.1)HR=5.7 (1.9 to 17.1)HR=2.1 (0.78 to 5.4)HR=5.3 (1.5 to 18.3)SurveillanceChT (CVB)ChT (BEP)RTChT + RTAge adjusted results. Patients withCAD before or within 2 years fromdiagnosis were excluded. Only 3of 420 RT treated patients had alsomed. RT
eISSN:
1581-3207
Idioma:
Inglés
Calendario de la edición:
4 veces al año
Temas de la revista:
Medicine, Clinical Medicine, Internal Medicine, Haematology, Oncology, Radiology