Association between polymorphisms in segregation genes BUB1B and TTK and gastric cancer risk
Categoría del artículo: Research Article
Publicado en línea: 19 jul 2016
Páginas: 297 - 307
Recibido: 13 mar 2015
Aceptado: 09 ago 2015
DOI: https://doi.org/10.1515/raon-2015-0047
Palabras clave
© 2016 Fazekas and Porvázsnyik, published by De Gruyter Open
This content is free.
Background
Malignant transformation of normal gastric cells is a complex and multistep process, resulting in development of heterogeneous tumours. Susceptible genetic background, accumulation of genetic changes, and environmental factors play an important role in gastric carcinogenesis. Single nucleotide polymorphisms (SNPs) in mitotic segregation genes could be responsible for inducing the slow process of accumulation of genetic changes, leading to genome instability.
Patients and methods
We performed a case-control study of polymorphisms in mitotic kinases
Results
C/G genotype of rs151658 was more frequent in patients with diffuse type of gastric cancer and G/G genotype was more common in intestinal types of gastric cancers (p = 0.049). Polymorphic genotype A/A of rs1801376 was associated with higher risk for developing diffuse type of gastric cancer in female population (p = 0.007), whereas A/A frequencies were increased in male patients with subserosa tumour cell infiltration (p = 0.009). T/T genotype of rs1031963 was associated with well differentiated tumours (p = 0.035). TT+CT genotypes of rs1031963 and GG+AG genotypes of rs1801376 were significantly associated with gastric cancer risk (dominant model; OR = 2,929, 95% CI: 1.281-6.700; p = 0.017 and dominant model; OR = 0,364, 95% CI: 0.192-0.691; p = 0.003 respectively).
Conclusions
Our results suggest that polymorphisms in mitotic kinases