<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The monoazo substituted five membered heterocycles, along with their seleno like moieties are still of interest in organic chemistry due to their medicinal and valuable applications. In continuation of our interest in the study of heterocyclic azo compounds containing sulphur and / or nitrogen heteroatoms, the synthesis of 5-aryl mono azo-thiazol-2-ylcarbamoyl-thiophene along with their seleno like derivatives of pyridine, pyridazine and quinolone, were accomplished. All the synthesized compounds were <italic>in vitro</italic> screening of their antioxidant activity, antitumor activity against Ehrlich ascites carcinoma cell EACC cell line and antimicrobial activity against various pathogenic microorganisms, such as Gram-positive bacteria (<italic>Bacillus subtilis</italic> and <italic>Staphylococcus aureus</italic>) and Gram-negative bacteria (<italic>Escherichia coli</italic> and <italic>Salmonella typhimurium</italic>) and fungi strains of <italic>Aspergillus flavus</italic> and <italic>Candida albicans</italic>. The structural–activity relationship was studied based on the obtained data.</p></abstract>

The monoazo substituted five membered heterocycles, along with their seleno like moieties are still of interest in organic chemistry due to their medicinal and valuable applications. In continuation of our interest in the study of heterocyclic azo compounds containing sulphur and / or nitrogen heteroatoms, the synthesis of 5-aryl mono azo-thiazol-2-ylcarbamoyl-thiophene along with their seleno like derivatives of pyridine, pyridazine and quinolone, were accomplished. All the synthesized compounds were in vitro screening of their antioxidant activity, antitumor activity against Ehrlich ascites carcinoma cell EACC cell line and antimicrobial activity against various pathogenic microorganisms, such as Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli and Salmonella typhimurium) and fungi strains of Aspergillus flavus and Candida albicans. The structural–activity relationship was studied based on the obtained data.

Biological screening and assessment of certain substituted monoazo heterocycles containing sulphur and / or nitrogen and their seleno like moieties

Department of Chemistry, Faculty of Science

Higher Institute for Engineering and Technology, Department of Chemical Engineering

Polish Journal of Chemical Technology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The monoazo substituted five membered heterocycles, along with their seleno like moieties are still of interest in organic chemistry due to their medicinal and...

Biological screening and assessment of certain substituted monoazo heterocycles containing sulphur and / or nitrogen and their seleno like moieties

Publicado en línea: 29 dic 2017

Páginas: 28 - 35

DOI: https://doi.org/10.1515/pjct-2017-0064

Palabras clave
thiophene, antioxidant activities, antitumor agents, pathogenic microorganisms, selenium

© 2017 Mohamed E. Khalifa et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Biological screening and assessment of certain substituted monoazo heterocycles containing sulphur and / or nitrogen and their seleno like moieties

Publicado en línea: 29 dic 2017

Páginas: 28 - 35

DOI: https://doi.org/10.1515/pjct-2017-0064

Palabras clavethiophene, antioxidant activities, antitumor agents, pathogenic microorganisms, selenium

© 2017 Mohamed E. Khalifa et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Palabras clave
thiophene, antioxidant activities, antitumor agents, pathogenic microorganisms, selenium