<abstract xmlns="http://www.w3.org/1999/xhtml">The present study demonstrates the antihypertensive effect of magnesium sulfate (Cormagnesin®) and its combination with Furosemide on conscious spontaneously hypertensive rats (SHR) after intravenous infusion. Experiments were carried out on six groups of conscious male SHR (n=6). Under short anesthesia the rats were chronically instrumented for intravenous (i.v.) drug administration. The arterial blood pressure (AP) was measured by indirect tale method. Cormagnesin® was applied by i.v. infusion in doses of 5, 20 and 40 mg/kg; and furosemide (10 mg/kg) was applied intraperitoneally. Experimental results showed significant decrease of AP after i.v. infusion of 20 mg/kg Cormagnesin® as well as after application of the Cormagnesin® and furosemide combination. The hypotensive effects of 40 mg/kg Cormagnesin® and of furosemide were not significant. There was no significant difference between the antihypertensive effects of Cormagnesin® and its combination with furosemide but the combination showed much better hypotensive effect than Furosemide (p&lt;0.05). Our study demonstrated the antihypertensive effect of magnesium sulfate on conscious SHR after i.v. application. Our results suggest that the antihypertensive effect of magnesium sulfate in the doses applied is not dose-dependent. Magnesium sulfate potentiates the antihypertensive effect of furosemide in SHR.</abstract>

The present study demonstrates the antihypertensive effect of magnesium sulfate (Cormagnesin®) and its combination with Furosemide on conscious spontaneously hypertensive rats (SHR) after intravenous infusion. Experiments were carried out on six groups of conscious male SHR (n=6). Under short anesthesia the rats were chronically instrumented for intravenous (i.v.) drug administration. The arterial blood pressure (AP) was measured by indirect tale method. Cormagnesin® was applied by i.v. infusion in doses of 5, 20 and 40 mg/kg; and furosemide (10 mg/kg) was applied intraperitoneally. Experimental results showed significant decrease of AP after i.v. infusion of 20 mg/kg Cormagnesin® as well as after application of the Cormagnesin® and furosemide combination. The hypotensive effects of 40 mg/kg Cormagnesin® and of furosemide were not significant. There was no significant difference between the antihypertensive effects of Cormagnesin® and its combination with furosemide but the combination showed much better hypotensive effect than Furosemide (p<0.05). Our study demonstrated the antihypertensive effect of magnesium sulfate on conscious SHR after i.v. application. Our results suggest that the antihypertensive effect of magnesium sulfate in the doses applied is not dose-dependent. Magnesium sulfate potentiates the antihypertensive effect of furosemide in SHR.

Antihypertensive Effect Of Magnesium Sulfate (Cormagnesin®) And Its Combination With Furosemide On Conscious Spontaneously Hypertensive Rats

Department of Pharmacology and Toxicology, Faculty of Medicine, Medical University Sofia

Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University Sofia

Journal of Biomedical and Clinical Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Antihypertensive Effect Of Magnesium Sulfate (Cormagnesin) And Its Combination With Furosemide On Conscious Spontaneously Hypertensive Rats

The present study demonstrates the antihypertensive effect of magnesium sulfate (Cormagnesin®) and its combination with Furosemide on conscious spontaneously...

Antihypertensive Effect Of Magnesium Sulfate (Cormagnesin^®) And Its Combination With Furosemide On Conscious Spontaneously Hypertensive Rats

Publicado en línea: 22 dic 2015

Páginas: 112 - 117

Recibido: 19 jun 2015

Aceptado: 01 dic 2015

DOI: https://doi.org/10.1515/jbcr-2015-0160

Palabras clave
magnesium sulfas, antihypertensive effect, SHR

© 2015 Katerina D. Simeonova et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Antihypertensive Effect Of Magnesium Sulfate (Cormagnesin®) And Its Combination With Furosemide On Conscious Spontaneously Hypertensive Rats

Publicado en línea: 22 dic 2015

Páginas: 112 - 117

Recibido: 19 jun 2015

Aceptado: 01 dic 2015

DOI: https://doi.org/10.1515/jbcr-2015-0160

Palabras clavemagnesium sulfas, antihypertensive effect, SHR

© 2015 Katerina D. Simeonova et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Antihypertensive Effect Of Magnesium Sulfate (Cormagnesin^®) And Its Combination With Furosemide On Conscious Spontaneously Hypertensive Rats

Palabras clave
magnesium sulfas, antihypertensive effect, SHR