<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Ferulic acid (FA), called also hydroxycinnamic acid, is a polyphenol compound found in many foods such as coffee, apples, rice, oats and wheat. It acts as an antioxidant but its other activities <italic>in vivo</italic> have not been well studied as a whole. The aim of the present study was to investigate the effects of FA on exploratory behavior and locomotor activity in male Wistar rats. FA was administrated orally (20 mg/kg) to different groups of rats for 7, 14, 21 and 30 days. These groups were compared respectively with saline-treated controls. At the end of each experimental period, the changes in exploratory behavior and locomotor activity were recorded in an Opto Varimex apparatus (Columbus Instruments, USA). The number of horizontal and vertical movements recorded every minute for the first 5 min served as a measure of exploratory activity and habituation to the new environment. The total number of movements during the first 5 min and during the whole 10-min period of observation was used as a measure of locomotor activity. It was found that FA at all doses for all treatment periods did not significantly affect exploratory behavior and locomotor activity of rats, when compared with the saline-treated controls. At all testing periods, FA did not disturb habituation. As habituation is considered an elementary form of learning, the present study suggested that FA did not disturb the memory and learning processes in rats.</p></abstract>

Ferulic acid (FA), called also hydroxycinnamic acid, is a polyphenol compound found in many foods such as coffee, apples, rice, oats and wheat. It acts as an antioxidant but its other activities in vivo have not been well studied as a whole. The aim of the present study was to investigate the effects of FA on exploratory behavior and locomotor activity in male Wistar rats. FA was administrated orally (20 mg/kg) to different groups of rats for 7, 14, 21 and 30 days. These groups were compared respectively with saline-treated controls. At the end of each experimental period, the changes in exploratory behavior and locomotor activity were recorded in an Opto Varimex apparatus (Columbus Instruments, USA). The number of horizontal and vertical movements recorded every minute for the first 5 min served as a measure of exploratory activity and habituation to the new environment. The total number of movements during the first 5 min and during the whole 10-min period of observation was used as a measure of locomotor activity. It was found that FA at all doses for all treatment periods did not significantly affect exploratory behavior and locomotor activity of rats, when compared with the saline-treated controls. At all testing periods, FA did not disturb habituation. As habituation is considered an elementary form of learning, the present study suggested that FA did not disturb the memory and learning processes in rats.

Effects Of Ferulic Acid On Exploratory Behavior And Locomotor Activity In Rats

Department of Preclinical and Clinical Pharmacology, Medical University Prof. Dr. Paraskev Stoyanov, Varna

Department of Behavior Neurobiology, Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia

Faculty of Pre-School and Primary School Education, SU “Sv. Kl. Ohridsky”, Sofia

Department of Pathophysiology, Medical University of Sofia, Sofia

Journal of Biomedical and Clinical Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Effects Of Ferulic Acid On Exploratory Behavior And Locomotor Activity In Rats"}

Ferulic acid (FA), called also hydroxycinnamic acid, is a polyphenol compound found in many foods such as coffee, apples, rice, oats and wheat. It acts as an...

Effects Of Ferulic Acid On Exploratory Behavior And Locomotor Activity In Rats

Publicado en línea: 10 dic 2015

Páginas: 81 - 87

Recibido: 19 oct 2014

Aceptado: 19 dic 2014

DOI: https://doi.org/10.1515/jbcr-2015-0130

Palabras clave
ferulic acid, exploratory behavior, locomotor activity, rats

© 2014 Stefka Valcheva-Kuzmanova et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Effects Of Ferulic Acid On Exploratory Behavior And Locomotor Activity In Rats

Publicado en línea: 10 dic 2015

Páginas: 81 - 87

Recibido: 19 oct 2014

Aceptado: 19 dic 2014

DOI: https://doi.org/10.1515/jbcr-2015-0130

Palabras claveferulic acid, exploratory behavior, locomotor activity, rats

© 2014 Stefka Valcheva-Kuzmanova et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Palabras clave
ferulic acid, exploratory behavior, locomotor activity, rats