Effect of 60 and 90 days of isotretinoin treatment on the structure of the small intestine mucosa in young male Wistar rats

Akman A, Durusoy C, Senturk M, Koc CK, Soyturk D, Alpsoy E. (2007). Treatment of acne with intermittent and conventional isotretinoin: a randomized, controlled multicenter study. Arch Dermatol Res299: 467–473.Search in Google Scholar

Azevedo JF de, Hermes C, Manzano MA, Araújo EJ de A, Sant’Ana D de MG. (2007). Análise morfométrica da parede intestinal do íleo de ratos submetidos a intensa carência de proteínas. Arq Ciênc Vet Zool Unipar10(2): 85–89.Search in Google Scholar

Barret KE. Gastrointestinal Physiology. Lange Medical Books: The McGraw Hill Companies. 2006. 294p.Search in Google Scholar

Bigby M, Stern RS. (1988). Adverse reactions to isotretinoin. A report from the Adverse Drug Reaction Reporting System. J Am Acad Dermatol18: 543–552.10.1016/S0190-9622(88)70078-XOpen DOISearch in Google Scholar

Bremner JD, McCaffery P. (2008). The neurobiology of retinoic acid in affective disorders. Prog Neuropsychopharmacol Biol Psychiatry32: 315–331.10.1016/j.pnpbp.2007.07.001Open DOISearch in Google Scholar

Brito Mde F, Sant’Anna IP, Galindo JC, Rosendo LH, Santos JB. (2010). Evaluation of clinical adverse effects and laboratory alterations in patients with acne vulgaris treated with oral isotretinoin. An Bras Dermatol85: 331–337.Search in Google Scholar

Chawla G, Gupta P, Koradia V, Bansal AK. (2013). Gastroretention. A means to address regional variability in intestinal drug absorption. Pharmaceutical TechnologyJuly: 50–68.Search in Google Scholar

Cisneros FJ, Gough BJ, Patton RE, Ferguson SA. (2005). Serum levels of albumin, triglycerides, total protein and glucose in rats are altered after oral treatment with low doses of 13-cis-retinoic acid or all-trans-retinoic acid. J Appl Toxicol25: 470–478.10.1002/jat.1082Open DOISearch in Google Scholar

Deplancke B, Gaskins HR. (2001). Microbial modulation of innate defense: goblet cells and the intestinal mucus layer. Am J Clin Nutr73: 1131S–1141S.Search in Google Scholar

Diniz DGA, Lima EM, Filho NRA. (2002). Isotretinoína: perfis farmacológicos, farmacocinético e analítico. Revista Brasileira de Ciências Farmacêuticas38(4): 415–430.Search in Google Scholar

Ferguson SA, Cisneros FJ, Gough B, Hanig JP, Berry KJ. (2005). Chronic oral treatment with 13-cis-retinoic acid (isotretinoin) or all-trans-retinoic acid does not alter depression-like behaviors in rats. Toxicol Sci87: 451–459.Search in Google Scholar

Frankel W, Zhang W, Singh A, Bain A, Satchithanandam S, Klurfeld D, Rom-beau J. (1995). Fiber: effect on bacterial translocation and intestinal mucin content. World J Surg19: 144–148; discussion 148–149.10.1007/BF00317001Open DOISearch in Google Scholar

Hardin JA, Chung B, O’Loughlin E V, Gall DG. (1999). The effect of epidermal growth factor on brush border surface area and function in the distal remnant following resection in the rabbit. Gut44: 26–32.10.1136/gut.44.1.26Open DOISearch in Google Scholar

Charakida A, Mouser PE, Chu AC. (2004). Safety and side effects of the acne drug, oral isotretinoin. Expert Opin Drug Saf3: 119–129.10.1517/14740338.3.2.119Open DOISearch in Google Scholar

Chia CY, Lane W, Chibnall J, Allen A, Siegfried E. (2005). Isotretinoin therapy and mood changes in adolescents with moderate to severe acne: a cohort study. Arch Dermatol141: 557–560.Search in Google Scholar

Junqueira LC, Carneiro J. Histologia Básica. Rio de Janeiro: Guanabara Koogan. 2015.Search in Google Scholar

Kierszenbaum A, Tres L. Histology and Cell Biology: An Introduction to Pathology. 752p. Saunders, 2011.Search in Google Scholar

Kim JJ, Khan WI. (2013). Goblet cells and mucins: role in innate defense in enteric infections. Pathogens2: 55–70.Search in Google Scholar

Lu X, Zhao J, Gregersen H. (2005). Small intestinal morphometric and biomechanical changes during physiological growth in rats. J Biomech38: 417–426.10.1016/j.jbiomech.2004.04.025Open DOISearch in Google Scholar

McCarter TL, Chen YK. (1992). Marked hyperlipidemia and pancreatitis associated with isotretinoin therapy. Am J Gastroenterol87: 1855–1858.Search in Google Scholar

Nankervis R, Davis SS, Day NH, Shaw PN. (1995). Effect of lipid vehicle on intestinal lymphatic transport of isotretinoin in the rat. The International Journal of Pharmaceutics119(2): 173–181.Search in Google Scholar

O’Reilly KC, Shumake J, Gonzalez-Lima F, Lane MA, Bailey SJ. (2006). Chronic administration of 13-cis-retinoic acid increases depression-related behavior in mice. Neuropsychopharmacology31: 1919–1927.10.1038/sj.npp.1300998Open DOISearch in Google Scholar

Ortonne JP. (1997). Oral isotretinoin treatment policy. Do we all agree? Dermatology195 Suppl 1: 34–37; discussion 38–40.Search in Google Scholar

Passier JL, Srivastava N, van Puijenbroek EP. (2006). Isotretinoin-induced inflammatory bowel disease. Neth J Med64: 52–54.Search in Google Scholar

Pelicano ERL, Souza PA de, Souza HBA de, Oba A, Norkus EA, Kodawara LM, et al. (2003). Morfometria e ultra-estrutura da mucosa intestinal de frangos de corte alimentados com dietas contendo diferentes probióticos. Rev Port Ciênc Vet98(547): 125–134.Search in Google Scholar

Reddy D, Siegel CA, Sands BE, Kane S. (2006). Possible association between isotretinoin and inflammatory bowel disease. Am J Gastroenterol101: 1569–1573.Search in Google Scholar

Shale M, Kaplan GG, Panaccione R, Ghosh S. (2009). Isotretinoin and intestinal inflammation: what gastroenterologists need to know. Gut58: 737–741.Search in Google Scholar

Shalita AR, Cunningham WJ, Leyden JJ, Pochi PE, Strauss JS. (1983). Isotretinoin treatment of acne and related disorders: an update. J Am Acad Dermatol9: 629–638.10.1016/S0190-9622(83)70176-3Open DOISearch in Google Scholar

Shirazi T, Longman RJ, Corfield AP, Probert CS. (2000). Mucins and inflammatory bowel disease. Postgrad Med J76: 473–478.10.1136/pmj.76.898.473174169110908374Open DOISearch in Google Scholar

Sieving PA, Chaudhry P, Kondo M, Provenzano M, Wu D, Carlson TJ, Bush RA, Thompson DA. (2001). Inhibition of the visual cycle in vivo by 13-cis retinoic acid protects from light damage and provides a mechanism for night blindness in isotretinoin therapy. Proc Natl Acad Sci U S A98: 1835–1840.10.1073/pnas.98.4.18352934311172037Open DOISearch in Google Scholar

Sundstrom A, Alfredsson L, Sjolin-Forsberg G, Gerden B, Bergman U, Jokinen J. (2010). Association of suicide attempts with acne and treatment with isotretinoin: retrospective Swedish cohort study. BMJ341: c5812.Search in Google Scholar

Thomazini BF, Dolder MA. (2017). Dose dependent treatment with isotretinoin induces more changes in the ileum than in the duodenum and jejunum in Wistar rats. Tissue Cell49(2 Pt B): 203–208.10.1016/j.tice.2017.03.00328341060Open DOISearch in Google Scholar

Tsukada M, Schroder M, Seltmann H, Orfanos CE, Zouboulis CC. (2002). High albumin levels restrict the kinetics of 13-cis retinoic acid uptake and intra-cellular isomerization to all-trans retinoic acid and inhibit its anti-proliferative effect on SZ95 sebocytes. J Invest Dermatol119: 182–185.Search in Google Scholar

Vieira-Lopes DA, Nascimento AA, Sales A, Ventura A, Novelli IA, Sousa BM, Pinheiro NL. (2014). Histologia e histoquímica do tubo digestório de Phrynops geoffroanus (Testudines, Chelidae). Acta Amazon44(1): 135–142.Search in Google Scholar

Walker MM, Talley NJ. (2011). Clinical value of duodenal biopsies--beyond the diagnosis of coeliac disease. Pathol Res Pract207: 538–544.Search in Google Scholar

Zane LT, Leyden WA, Marqueling AL, Manos MM. (2006). A population-based analysis of laboratory abnormalities during isotretinoin therapy for acne vulgaris. Arch Dermatol142: 1016–1022.Search in Google Scholar