Hypoxic regulation of the expression of genes encoded estrogen related proteins in U87 glioma cells: eff ect of IRE1 inhibition

Acosta-Alvear D, Zhou Y, Blais A, Tsikitis M, Lents NH, Arias C, Lennon CJ, Kluger Y, Dynlacht BD. XBP1 controls diverse cell type- and condition-specifi c transcriptional regulatory networks. Mol Cell 27, 53-66, 2007.10.1016/j.molcel.2007.06.01117612490Search in Google Scholar

Aragon T, van Anken E, Pincus D, Serafi mova IM, Korennykh AV, Rubio CA, Walter P. Messenger RNA targeting to endoplasmic reticulum stress signalling sites. Nature 457, 736-740, 2009.10.1038/nature07641276853819079237Search in Google Scholar

Auf G, Jabouille A, Guerit S, Pineau R, Delugin M, Bouchecareilh M, Favereaux A, Maitre M, Gaiser T, von Deimling A, Czabanka M, Vajkoczy P, Chevet E, Bikfalvi A, Moenner M. A shift from an angiogenic to invasive phenotype induced in malignant glioma by inhibition of the unfolded protein response sensor IRE1. Proc Natl Acad Sci U S A 107, 15553-15558, 2010.10.1073/pnas.0914072107293260020702765Search in Google Scholar

Auf G, Jabouille A, Delugin M, Guerit S, Pineau R, North S, Platonova N, Maitre M, Favereaux A, Vajkoczy P, Seno M, Bikfalvi A, Minchenko D, Minchenko O, Moenner M. High epiregulin expression in human U87 glioma cells relies on IRE1alpha and promotes autocrine growth through EGF receptor. BMC Cancer 13, 597, 2013.10.1186/1471-2407-13-597387867024330607Search in Google Scholar

Aziz MH, Chen X, Zhang Q, DeFrain C, Osland J, Luo Y, Shi X, Yuan R. Suppressing NRIP1 inhibits growth of breast cancer cells in vitro and in vivo. Oncotarget 6, 39714-39724, 2015.10.18632/oncotarget.5356474185726492163Search in Google Scholar

Bell JL, Malyukova A, Kavallaris M, Marshall GM, Cheung BB. TRIM16 inhibits neuroblastoma cell proliferation through cell cycle regulation and dynamic nuclear localization. Cell Cycle 12, 889-898, 2013.10.4161/cc.23825363734723422002Search in Google Scholar

Bochkov VN, Philippova M, Oskolkova O, Kadl A, Furnkranz A, Karabeg E, Breuss J, Minchenko OH, Mechtcheriakova D, Hohensinner P, Rychli K, Wojta J, Resink T, Binder BR, Leitinger N. Oxidized phospholipids stimulate angiogenesis via induction of VEGF, IL-8, COX-2 and ADAMTS-1 metalloprotease, implicating a novel role for lipid oxidation in progression and destabilization of atherosclerotic lesions. Circ Res 99, 900-908, 2006.10.1161/01.RES.0000245485.04489.ee16973904Search in Google Scholar

Casaburi I, Avena P, De Luca A, Chimento A, Sirianni R, Malivindi R, Rago V, Fiorillo M, Domanico F, Campana C, Cappello AR, Sotgia F, Lisanti MP, Pezzi V. Estrogen related receptor alpha (ERRalpha) a promising target for the therapy of adrenocortical carcinoma (ACC). Oncotarget 6, 25135-25148, 2015.10.18632/oncotarget.4722469482026312764Search in Google Scholar

Chevet E, Hetz C, Samali A. Endoplasmic reticulum stress-activated cell reprogramming in oncogenesis. Cancer Discov 5, 586-597, 2015.10.1158/2159-8290.CD-14-149025977222Search in Google Scholar

Cho YE, Kim JY, Kim YW, Park JH, Lee S. Expression and prognostic signifi cance of human growth and transformation- dependent protein in gastric carcinoma and gastric adenoma. Hum Pathol 40, 975-981, 2009.10.1016/j.humpath.2008.12.00719269009Search in Google Scholar

Cho YE, Kim JY, Kim YJ, Kim YW, Lee S, Park JH. Expression and clinicopathological signifi cance of human growth and transformation-dependent protein (HGTD-P) in uterine cervical cancer. Histopathology 57, 479-482, 2010.10.1111/j.1365-2559.2010.03627.x306641020840676Search in Google Scholar

Clarke HJ, Chambers JE, Liniker E, Marciniak SJ. Endoplasmic reticulum stress in malignancy. Cancer Cell 25, 563-573, 2014.10.1016/j.ccr.2014.03.01524823636Search in Google Scholar

Cookman CJ, Belcher SM. Estrogen receptor-β Up-regulates IGF1R rxpression and activity to inhibit apoptosis and increase growth of medulloblastoma. Endocrinology 156, 2395-2408, 2015.10.1210/en.2015-1141447572125885794Search in Google Scholar

Dejeans N, Pluquet O, Lhomond S, Grise F, Bouchecareilh M, Juin A, Meynard-Cadars M, Bidaud-Meynard A, Gentil C, Moreau V, Saltel F, Chevet E. Autocrine control of glioma cells adhesion and migration through IRE1a-mediated cleavage of SPARC mRNA. J Cell Sci 125, 4278-4287, 2012.10.1242/jcs.099291Search in Google Scholar

Dejeans N, Barroso K, Fernandez-Zapico ME, Samali A, Chevet E. Novel roles of the unfolded protein response in the control of tumor development and aggressiveness. Semin Cancer Biol 33, 67-73, 2015.10.1016/j.semcancer.2015.04.00725953433Search in Google Scholar

De Luca A, Fiorillo M, Peiris-Pages M, Ozsvari B, Smith DL, Sanchez-Alvarez R, Martinez-Outschoorn UE, Cappello AR, Pezzi V, Lisanti MP, Sotgia F. Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells. Oncotarget 6, 14777-14795, 2015.10.18632/oncotarget.4401455811526087310Search in Google Scholar

Drogat B, Auguste P, Nguyen DT, Bouchecareilh M, Pineau R, Nalbantoglu J, Kaufman RJ, Chevet E, Bikfalvi A, Moenner M. IRE1 signaling is essential for ischemia-induced vascular endothelial growth factor-A expression and contributes to angiogenesis and tumor growth in vivo. Cancer Res 67, 6700-6707, 2007.10.1158/0008-5472.CAN-06-323517638880Search in Google Scholar

Gibson WJ, Hoivik EA, Halle MK, Taylor-Weiner A, Cherniack AD, Berg A, Holst F, Zack TI, Werner HM, Staby KM, Rosenberg M, Stefansson IM, Kusonmano K, Chevalier A, Mauland KK, Trovik J, Krakstad C, Giannakis M, Hodis E, Woie K, Bjorge L, Vintermyr OK, Wala JA, Lawrence MS, Getz G, Carter SL, Beroukhim R, Salvesen HB. The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis. Nat Genet 48, 848-855, 2016.10.1038/ng.3602496327127348297Search in Google Scholar

Hamidian A, von Stedingk K, Munksgaard Th oren M, Mohlin S, Pahlman S. Diff erential regulation of HIF-1alpha and HIF-2alpha in neuroblastoma: Estrogen-related receptor alpha (ERRalpha) regulates HIF2A transcription and correlates to poor outcome. Biochem Biophys Res Commun 461, 560-567, 2015.10.1016/j.bbrc.2015.04.08325912138Search in Google Scholar

Kim JH, Jeong IY, Lim Y, Lee YH, Shin SY. Estrogen receptor beta stimulates Egr-1 transcription via MEK1/Erk/Elk-1 cascade in C6 glioma cells. BMB Rep 44, 452-457, 2011.10.5483/BMBRep.2011.44.7.45221777515Search in Google Scholar

Kim PY, Rahmanto AS, Tan O, Norris MD, Haber M, Marshall GM, Cheung BB. TRIM16 overexpression induces apoptosis through activation of caspase-2 in cancer cells. Apoptosis 18, 639-651, 2013.10.1007/s10495-013-0813-y361841323404198Search in Google Scholar

Kim PY, Tan O, Liu B, Trahair T, Liu T, Haber M, Norris MD, Marshall GM, Cheung BB. High TDP43 expression is required for TRIM16-induced inhibition of cancer cell growth and correlated with good prognosis of neuroblastoma and breast cancer patients. Cancer Lett 374, 315-323, 2016.10.1016/j.canlet.2016.02.02126902425Search in Google Scholar

Lapierre M, Docquier A, Castet-Nicolas A, Gitenay D, Jalaguier S, Teyssier C, Cavailles V. Th e emerging role of the transcriptional coregulator RIP140 in solid tumors. Biochim Biophys Acta 1856, 144-150, 2015.10.1016/j.bbcan.2015.06.00626116758Search in Google Scholar

Lau KM, To KF. Importance of estrogenic signaling and its mediated receptors in prostate cancer. Int J Mol Sci 17, pii: E1434, 2016.10.3390/ijms17091434503771327589731Search in Google Scholar

Lee MJ, Kim JY, Suk K, Park JH. Identifi cation of the hypoxia-inducible factor 1 alpha-responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathway. Mol Cell Biol 24, 3918-3927, 2004.10.1128/MCB.24.9.3918-3927.200438774315082785Search in Google Scholar

Lenihan CR, Taylor CT. Th e impact of hypoxia on cell death pathways. Biochem Soc Trans 41, 657-663, 2013.10.1042/BST2012034523514172Search in Google Scholar

Li W, Winters A, Poteet E, Ryou MG, Lin S, Hao S, Wu Z, Yuan F, Hatanpaa KJ, Simpkins JW, Yang SH. Involvement of estrogen receptor β5 in the progression of glioma. Brain Res 1503, 97-107, 2013.10.1016/j.brainres.2013.02.004364656623399685Search in Google Scholar

Li L, Dong L, Qu X, Jin S, Lv X, Tan G. Tripartite motif 16 inhibits hepatocellular carcinoma cell migration and invasion. Int J Oncol 48, 1639-1649, 2016.10.3892/ijo.2016.339826892350Search in Google Scholar

Lian J, Jing Y, Dong Q, Huan L, Chen D, Bao C, Wang Q, Zhao F, Li J, Yao M, Qin L, Liang L, He X. miR-192, a prognostic indicator, targets the SLC39A6/SNAIL pathway to reduce tumor metastasis in human hepatocellular carcinoma. Oncotarget 7, 2672-2683, 2016.10.18632/oncotarget.6603482306326684241Search in Google Scholar

Manie SN, Lebeau J, Chevet E. Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 3. Orchestrating the unfolded protein response in oncogenesis: an update. Am J Physiol Cell Physiol 307, C901-C907, 2014.10.1152/ajpcell.00292.201425186011Search in Google Scholar

Matsushima H, Mori T, Ito F, Yamamoto T, Akiyama M, Kokabu T, Yoriki K, Umemura S, Akashi K, Kitawaki J. Anti-tumor eff ect of estrogen-related receptor alpha knockdown on uterine endometrial cancer. Oncotarget 7, 34131-34148, 2016.10.18632/oncotarget.9151508514227153547Search in Google Scholar

Maurel M, Chevet E, Tavernier J, Gerlo S. Getting RIDD of RNA: IRE1 in cell fate regulation. Trends Biochem Sci 39, 245-254, 2014.10.1016/j.tibs.2014.02.00824657016Search in Google Scholar

Maurel M, McGrath EP, Mnich K, Healy S, Chevet E, Samali A. Controlling the unfolded protein response-mediated life and death decisions in cancer. Semin Cancer Biol 33, 57-66, 2015.10.1016/j.semcancer.2015.03.00325814342Search in Google Scholar

Minchenko DO, Kharkova AP, Tsymbal DO, Karbovskyi LL, Minchenko OH. Expression of insulin-like growth factor binding protein genes and its hypoxic regulation in U87 glioma cells depends on ERN1 mediated signaling pathway of endoplasmic reticulum stress. Endocr Regul 49, 73-83, 2015.10.4149/endo_2015_02_7325960008Search in Google Scholar

Mueller MD, Vigne JL, Minchenko AG, Lebovic DI, Leitman DC, Taylor RN. Regulation of vascular endothelial growth factor (VEGF) gene transcription by estrogen receptors alpha and beta. Proc Natl Acad Sci USA 97, 10972-10977, 2000.10.1073/pnas.2003770972713310995484Search in Google Scholar

Pedram A, Razandi M, Wallace DC, Levin ER. Functional estrogen receptors in the mitochondria of breast cancer cells. Mol Biol Cell 17, 2125-2137, 2006.10.1091/mbc.e05-11-1013144607116495339Search in Google Scholar

Petersen SL, Intlekofer KA, Moura-Conlon PJ, Brewer DN, Del Pino Sans J, Lopez JA. Novel progesterone receptors: neural localization and possible functions. Front Neurosci 7, 164, 2013.10.3389/fnins.2013.00164377695324065878Search in Google Scholar

Pluquet O, Dejeans N, Bouchecareilh M, Lhomond S, Pineau R, Higa A, Delugin M, Combe C, Loriot S, Cubel G, Dugot-Senant N, Vital A, Loiseau H, Gosline SJ, Taouji S, Hallett M, Sarkaria JN, Anderson K, Wu W, Rodriguez FJ, Rosenbaum J, Saltel F, Fernandez-Zapico ME, Chevet E. Posttranscriptional regulation of PER1 underlies the oncogenic function of IREα. Cancer Res 73, 4732-4743, 2013.10.1158/0008-5472.CAN-12-3989391571623752693Search in Google Scholar

Pluquet O, Dejeans N, Chevet E. Watching the clock: endoplasmic reticulum-mediated control of circadian rhythms in cancer. Ann Med 46, 233-243, 2014.10.3109/07853890.2013.87466424491143Search in Google Scholar

Rajapaksa G, Th omas C, Gustafsson JA. Estrogen signaling and unfolded protein response in breast cancer. J Steroid Biochem Mol Biol 163, 45-50, 2016.10.1016/j.jsbmb.2016.03.03627045680Search in Google Scholar

Ranhotra HS. Estrogen-related receptor alpha and cancer: axis of evil. J Recept Signal Transduct Res 35, 505-508, 2015.10.3109/10799893.2015.104936226446880Search in Google Scholar

Rohatgi N, Matta A, Kaur J, Srivastava A, Ralhan R. Novel molecular targets of smokeless tobacco (khaini) in cell culture from oral hyperplasia. Toxicology 224, 1-13, 2006.10.1016/j.tox.2006.03.014Search in Google Scholar

Schaner ME, Ross DT, Ciaravino G, Sorlie T, Troyanskaya O, Diehn M, Wang YC, Duran GE, Sikic TL, Caldeira S, Skomedal H, Tu IP, Hernandez-Boussard T, Johnson SW, O’Dwyer PJ, Fero MJ, Kristensen GB, Borresen- Dale AL, Hastie T, Tibshirani R, van de Rijn M, Teng NN, Longacre TA, Botstein D, Brown PO, Sikic BI. Gene expression patterns in ovarian carcinomas. Mol Biol Cell 14, 4376-4386, 2003.10.1091/mbc.e03-05-0279Search in Google Scholar

Sutton SK, Koach J, Tan O, Liu B, Carter DR, Wilmott JS, Yosufi B, Haydu LE, Mann GJ, Thompson JF, Long GV, Liu T, McArthur G, Zhang XD, Scolyer RA, Cheung BB, Marshall GM. TRIM16 inhibits proliferation and migration through regulation of interferon beta 1 in melanoma cells. Oncotarget 5, 10127-10139, 2014.10.18632/oncotarget.2466Search in Google Scholar

Takatani-Nakase T, Matsui C, Maeda S, Kawahara S, Takahashi K. High glucose level promotes migration behavior of breast cancer cells through zinc and its transporters. PLoS ONE 9, E90136, 2014.10.1371/journal.pone.0090136Search in Google Scholar

Tavares CB, Gomes-Braga Fd, Costa-Silva DR, Escorcio-Dourado CS, Borges US, Conde-Junior AM, Barros-Oliveira Mda C, Sousa EB, Barros Lda R, Martins LM, Facina G, da-Silva BB. Expression of estrogen and progesterone receptors in astrocytomas: a literature review. Clinics (Sao Paulo) 71, 481-486, 2016.10.6061/clinics/2016(08)12Search in Google Scholar

Taylor KM, Muraina IA, Brethour D, Schmitt-Ulms G, Nimmanon T, Ziliotto S, Kille P, Hogstrand C. Zinc transporter ZIP10 forms a heteromer with ZIP6 which regulates embryonic development and cell migration. Biochem J 473, 2531-2544, 2016.10.1042/BCJ20160388498080827274087Search in Google Scholar

Tiwari A, Swamy S, Gopinath KS, Kumar A. Genomic amplifi cation upregulates estrogen-related receptor alpha and its depletion inhibits oral squamous cell carcinoma tumors in vivo. Sci Rep 5, 17621, 2015.10.1038/srep17621467102626639757Search in Google Scholar

Treuter E, Albrektsen T, Johansson L, Leers J, Gustafsson JA. A regulatory role for RIP140 in nuclear receptor activation. Mol Endocrinol 12, 864-881, 1998.10.1210/mend.12.6.01239626662Search in Google Scholar

Ur Rahman MS, Cao J. Estrogen receptors in gastric cancer: Advances and perspectives. World J Gastroenterol 22, 2475-2482, 2016.10.3748/wjg.v22.i8.2475476819326937135Search in Google Scholar

Wada J, Nakatsuka A. Mitochondrial dynamics and mitochondrial dysfunction in diabetes. Acta Med Okayama 70, 151-158, 2016.Search in Google Scholar

Wallace DC, Fan W, Procaccio V. Mitochondrial energetics and therapeutics. Annu Rev Pathol 5, 297-348, 2010.10.1146/annurev.pathol.4.110807.092314324571920078222Search in Google Scholar

Wang D, Liang J, Zhang Y, Gui B, Wang F, Yi X, Sun L, Yao Z, Shang Y. Steroid receptor coactivator-interacting protein (SIP) inhibits caspase-independent apoptosis by preventing apoptosis-inducing factor (AIF) from being released from mitochondria. J Biol Chem 287, 12612-12621, 2012.10.1074/jbc.M111.334151333996122371500Search in Google Scholar

Wendler A, Wehling M. PGRMC2, a yet uncharacterized protein with potential as tumor suppressor, migration inhibitor, and regulator of cytochrome P450 enzyme activity. Steroids 78, 555-558, 2013.10.1016/j.steroids.2012.12.00223276631Search in Google Scholar

Wesolowska M, Pawlik P, Jagodzinski PP. Th e clinicopathologic signifi cance of estrogen receptors in human gastric carcinoma. Biomed Pharmacother 83, 314-322, 2016.10.1016/j.biopha.2016.06.04827399808Search in Google Scholar

Ye X, Zhang Y, He B, Meng Y, Li Y, Gao Y. Quantitative proteomic analysis identifi es new eff ectors of FOXM1 involved in breast cancer cell migration. Int J Clin Exp Pathol 8, 15836-15844, 2015.Search in Google Scholar

Zhang LD, Chen L, Zhang M, Qi HJ, Chen L, Chen HF, Zhong MK, Shi XJ, Li QY. Downregulation of ERRα inhibits angiogenesis in human umbilical vein endothelial cells through regulating VEGF production and PI3K/Akt/STAT3 signaling pathway. Eur J Pharmacol 769, 167-176, 2015.10.1016/j.ejphar.2015.11.01426586335Search in Google Scholar

Zhu J, Zhuang T, Yang H, Li X, Liu H, Wang H. Atypical ubiquitin ligase RNF31: the nuclear factor modulator in breast cancer progression. BMC Cancer 16, 538, 2016. 10.1186/s12885-016-2575-8496241627460922Search in Google Scholar