PECAM-1 gene polymorphism (rs668) and subclinical markers of carotid atherosclerosis in patients with type 2 diabetes mellitus
, , , , , , y | 02 ago 2016
Acerca de este artículo
Article Category: Original Article
Publicado en línea: 02 ago 2016
Páginas: 63 - 70
DOI: https://doi.org/10.1515/bjmg-2016-0008
Palabras clave
© 2016 Walter de Gruyter GmbH, Berlin/Boston
This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Changes in ultrasound markers of carotid artery atherosclerosis in patients with type 2 diabetes mellitus between the first and the second ultrasound examination of the carotid arteries according to the PECAM gene polymorphism 373 C/G (rs668) genotypes.
| Parameters | CC Genotype | CG Genotype | GG Genotype | |
|---|---|---|---|---|
| Annual CIMT increment (μm/year) | 20.34 (11.64-28.04) | 20.69 (7.14-32.28) | 14.28 (10.71-35.97) | 0.71 |
| Δ number of plaque segments | 2.00 (0.50-2.50) | 2.00 (1.00-3.00) | 2.00 (2.00-3.00) | 0.74 |
| Δ sum of the plaque thickness (mm) | 7.30 (3.85-8.70) | 5.45 (2.30-9.20) | 4.40 (1.40-8.42) | 0.38 |
Relationship of the PECAM gene polymorphism 373 C/G (rs668) genotypes to the presence of plaques/ unstable plaques of the carotid arteries in patients with type 2 diabetes mellitus at the beginning of the study.
| Presence of Plaques | Presence of Unstable Plaques | |||
|---|---|---|---|---|
| Parameters | OR (95% CI) | OR (95% CI) | ||
| Hypertension (0 = no; 1 = yes) | 1.88 | 0.35 | 1.38 | 0.52 |
| Systolic pressure (mm Hg) | 0.24 | 0.68 | 0.26 | 0.32 |
| Serum LDL (mmol/L) | 1.41 | 0.41 | 1.34 | 0.25 |
| Serum HDL (mmol/L) | 0.11 | 0.02 | 0.31 | 0.34 |
| Hb A1c (%) | 0.89 | 0.03 | 1.23 | 0.43 |
| CG allele | 1.03 | 0.49 | 0.72 | 0.17 |
| GG allele | 1.18 | 0.03 | 0.68 | 0.51 |
Initial clinical and biochemical characteristics of patients with type 2 diabetes mellitus and the control group.
| Parameters | Patients with T2DM ( | Control Group ( | |
|---|---|---|---|
| Age (mean ± SD) | 61.38 ± 9.65 | 60.07 ± 9.18 | 0.07 |
| Sex: M (%); F (%) | M: 338 (56.8); F: 191 (43.2) | M: 92 (46.0); F: 108 (54.0) | 0.008 |
| Duration of T2DM | 11.5 ± 7.88 | - | - |
| Smokers: M (%); F (%) | M: 30 (8.9); F: 23 (12.0) | M: 19 (20.6); F: 15 (13.9) | 0.002 |
| Waist circumference (cm) | 108.65 ± 12.88 | 93.31 ± 13.18 | <0.001 |
| BMI (kg/m2) | 30.96 ± 4.74 | 27.90 ± 4.42 | 0.16 |
| Systolic pressure (mm Hg) | 146.98 ± 19.98 | 143.30 ± 16.60 | 0.86 |
| Diastolic pressure (mm Hg) | 85.75 ± 11.62 | 84.70 ± 11.60 | 0.19 |
| Fasting glucose (mmol/L) | 8.04 ± 2.57 | 5.27 ± 0.87 | <0.001 |
| Hb A1c (%) | 7.89 ± 3.56 | 4.79 ± 0.29 | <0.001 |
| Total cholesterol (nmol/L) | 4.70 ± 1.19 | 5.36 ± 1.08 | <0.001 |
| HDL cholesterol (mmol/L) | 1.19 ± 0.35 | 1.43 ± 0.37 | <0.001 |
| LDL cholesterol (mmol/L) | 2.63 ± 0.94 | 3.24 ± 0.98 | <0.001 |
| Triglycerides (mmol/L) | 1.90 (1.20-2.70) | 1.30 (0.90-1.90) | <0.001 |
| High sensitivity CRP (mg/L) | 2.20 (1.00-4.30) | 1.30 (0.80-2.70) | <0.001 |
| CIMT (μm) | 1013.00 ± 208.00 | 979.00 ± 141.00 | 0.030 |
Comparison of ultrasound markers of the carotid artery atherosclerosis in patients with type 2 diabetes mellitus according to the PECAM gene polymorphism 373 C/G (rs668) genotypes at the beginning of the study.
| Parameters | CC Genotype | CG Genotype | GG Genotype | |
|---|---|---|---|---|
| CIMT (μm) | 1041.00 ± 198.00 | 990.00 ± 187.00 | 988.00 ± 211.00 | 0.19 |
| Number of segments with plaques | 2.56 ± 1.65 | 2.39 ± 1.72 | 2.51 ± 1.54 | 0.36 |
| Sum of the plaque thickness (mm) | 8.14 ± 4.77 | 7.99 ± 5.23 | 7.66 ± 4.02 | 0.16 |
| Presence of plaques: [+] | 149.00 (85.60) | 256.00 (84.50) | 94.00 (79.70) | 0.36 |
| Presence of unstable plaques: [+] | 86.00 (57.70) | 144.00 (56.30) | 58.00 (61.70) | 0.66 |
Changes in ultrasound markers of atherosclerosis at carotid artery in patients with type 2 diabetes mellitus and the control group between the initial and control ultrasound examinations.
| Parameters | Patients with T2DM ( | Control Group ( | 0.50 |
|---|---|---|---|
| Annual CIMT increment (μm/year) | 20.33 (11.74-29.86) | 12.83 (8.82-20.66) | 0.00 |
| Δ number of plaque segments | 2.00 (1.00-3.00) | 1.50 (0.70-2.20) | 0.00 |
| Δ sum of the plaque thickness (mm) | 5.40 (2.40-7.05) | 3.64 (2.88-5.48) | 0.02 |