The influence of CYP2C8*3 on carbamazepine serum concentration in epileptic pediatric patients
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02 ago 2016
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Categoría del artículo: Original Article
Publicado en línea: 02 ago 2016
Páginas: 21 - 28
DOI: https://doi.org/10.1515/bjmg-2016-0003
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© 2016 Walter de Gruyter GmbH, Berlin/Boston
This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Nucleotide change, haplotype and genotype frequencies of CYP2C8 in Serbian epileptic pediatric patients on carbamazepine treatment_
| Observed Frequency | 95% CI | |
|---|---|---|
| Nucleotide change: | 0.100 (8/80) | 0.050, 0.188 |
| Haplotype: | 0.900 (72/80) | 0.812, 0.950 |
| Genotype: | 0.825 (33/40) | 0.676, 0.861 |
The final model parameter estimates_
| Parameters | NONMEM | Bootstrap Analysis | ||
|---|---|---|---|---|
| Estimate | 95% CI Estimate ± 1.96 × (standard error of the estimate). | Estimate | 95% CI Percentile (2.5 and 97.5) of the ranked bootstrap parameter estimates. | |
| Clearance (L/h) | 0.215 | 0.176-0.254 | 0.207 | 0.189-0.225 |
| Sex | 0.0696 | 0.0545-0.0847 | 0.0698 | 0.0527-0.869 |
| Daily dose of carbamazepine (mg/L) | 0.000183 | 0.000079-0.000287 | 0.000194 | 0.000141-0.000247 |
| Inter-individual variance of CL | 0.0626 | 0.0371-0.0881 | 0.0669 | 0.058-0.0758 |
| Residual variance (exponential) | 0.0249 | 0.018-0.318 | 0.0262 | 0.023-0.0294 |