<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Introduction</bold>: Pre-eclampsia is a pregnancy-specific disease characterized by hypertension after 20 weeks of gestation and proteinuria. It is a major cause of maternal and perinatal morbidity and mortality. The pathogenesis of pre-eclampsia is not completely understood. In our study we investigated if there is a potential link between cytomegalovirus infection and pre-eclampsia and if cytomegalovirus infection is the triggering factor of pre-eclampsia.<bold>Material and methods</bold>: This study was carried out in a secondary care hospital between January 2014 and July 2015. We included two groups of pregnant women: 66 with pre-eclampsia and 62 without pre-eclampsia. Enzyme linked immunosorbent assay (ELISA) technique was performed to detect cytomegalovirus Immunoglobulin G levels in maternal serum.<bold>Results</bold>: The p-value between median values of positive cytomegalovirus IgG in pre-eclamptic women and in controls was not significant (p:0.867). Odds ratio for cytomegalovirus IgG in pre-eclamptic group (OR:0.967; 95%CI:0.535-1.748) do not differ greatly from the value recorded in the control group (OR:1.036; 95%CI:0.571-1.880). The risk for preterm birth in pre-eclamptic women with cytomegalovirus IgG positive values (OR:1.009; 95%CI:0.329-3.090) was greater than those which had term delivery (OR:0.994; 95%CI:0.472-2.095) but the two values are not very high. We found a positive correlation coefficient (0.217) at a “p” value of 0.08 between white blood cells, but a negative correlation coefficient between the percentage of neutrophils and cytomegalovirus infection.<bold>Conclusion</bold>: Cytomegalovirus infection may be associated with pre-eclampsia but it is unlikely to be the triggering factor of pre-eclampsia.</abstract>

Introduction: Pre-eclampsia is a pregnancy-specific disease characterized by hypertension after 20 weeks of gestation and proteinuria. It is a major cause of maternal and perinatal morbidity and mortality. The pathogenesis of pre-eclampsia is not completely understood. In our study we investigated if there is a potential link between cytomegalovirus infection and pre-eclampsia and if cytomegalovirus infection is the triggering factor of pre-eclampsia.Material and methods: This study was carried out in a secondary care hospital between January 2014 and July 2015. We included two groups of pregnant women: 66 with pre-eclampsia and 62 without pre-eclampsia. Enzyme linked immunosorbent assay (ELISA) technique was performed to detect cytomegalovirus Immunoglobulin G levels in maternal serum.Results: The p-value between median values of positive cytomegalovirus IgG in pre-eclamptic women and in controls was not significant (p:0.867). Odds ratio for cytomegalovirus IgG in pre-eclamptic group (OR:0.967; 95%CI:0.535-1.748) do not differ greatly from the value recorded in the control group (OR:1.036; 95%CI:0.571-1.880). The risk for preterm birth in pre-eclamptic women with cytomegalovirus IgG positive values (OR:1.009; 95%CI:0.329-3.090) was greater than those which had term delivery (OR:0.994; 95%CI:0.472-2.095) but the two values are not very high. We found a positive correlation coefficient (0.217) at a “p” value of 0.08 between white blood cells, but a negative correlation coefficient between the percentage of neutrophils and cytomegalovirus infection.Conclusion: Cytomegalovirus infection may be associated with pre-eclampsia but it is unlikely to be the triggering factor of pre-eclampsia.

Cytomegalovirus Infection and Pre-Eclampsia

Department of Obstetrics and Gynecology II, University of Medicine and Pharmacy of Tirgu. Mureş, Romania

Department of Central Laboratory, Emergency University Hospital, Tirgu Mureş, Romania

Department of Management and Economy, University Petru Maior of Tirgu Mureş, Romania

Department of Infectious Diseases, University of Medicine and Pharmacy of Tirgu Mureş, Romania

Acta Marisiensis - Seria Medica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Cytomegalovirus Infection and Pre-Eclampsia"}

Introduction: Pre-eclampsia is a pregnancy-specific disease characterized by hypertension after 20 weeks of gestation and proteinuria. It is a major cause of...

Cytomegalovirus Infection and Pre-Eclampsia

Publicado en línea: 20 may 2016

Páginas: 280 - 284

Recibido: 30 ene 2016

Aceptado: 22 mar 2016

DOI: https://doi.org/10.1515/amma-2016-0023

Palabras clave
Cytomegalovirus infection (CMV), pre-eclampsia (PE), Enzyme linked immunosorbent assay (ELISA), Immunoglobulin G (IgG), Interleukine (IL)

© 2016 Rădulescu Carmen et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Cytomegalovirus Infection and Pre-Eclampsia

Publicado en línea: 20 may 2016

Páginas: 280 - 284

Recibido: 30 ene 2016

Aceptado: 22 mar 2016

DOI: https://doi.org/10.1515/amma-2016-0023

Palabras claveCytomegalovirus infection (CMV), pre-eclampsia (PE), Enzyme linked immunosorbent assay (ELISA), Immunoglobulin G (IgG), Interleukine (IL)

© 2016 Rădulescu Carmen et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Palabras clave
Cytomegalovirus infection (CMV), pre-eclampsia (PE), Enzyme linked immunosorbent assay (ELISA), Immunoglobulin G (IgG), Interleukine (IL)