[1. Labay E, Efimova EV, Quarshie BK, Golden DW, Weichselbaum RR, Kron SJ. Ionizing radiation-induced foci persistence screen to discover enhancers of accelerated senescence. Int J High Throughput Screen 2011:2:1-13. doi: 10.2147/IJHTS.S17076]Search in Google Scholar
[2. Garg AK, Buchholz TA, Aggarwal BB. Chemosensitization and radiosensitization of tumors by plant polyphenols. Antioxid Redox Signal 2005;7:1630-47. doi: 10.1089/ ars.2005.7.1630]Search in Google Scholar
[3. Hazra B, Ghosh S, Kumar A, Pandey BN. The prospective role of plant products in radiotherapy of cancer: a current overview. Front Pharmacol 2012;2:94. doi: 10.3389/ fphar.2011.00094]Search in Google Scholar
[4. Rosenberg A, Knox S. Radiation sensitization with redox modulators: a promising approach. Int J Radiat Oncol Biol Phys 2006;64:343-54. doi: 10.1016/j.ijrobp.2005.10.013]Search in Google Scholar
[5. Papazisis KT, Zambouli D, Kimoundri OT, Papadakis ES, Vala V, Geromichalos GD, Voyatzi S, Markala D, Destouni E, Boutis L, Kortsaris AH. Protein tyrosine kinase inhibitor, genistein, enhances apoptosis and cell cycle arrest in K562 cells treated with gamma-irradiation. Cancer Lett 2000;160:107-13. doi: 10.1016/S0304-3835(00)00569-3]Search in Google Scholar
[6. Begg AC, Stewart FA, Vens C. Strategies to improve radiotherapy with targeted drugs. Nat Rev Cancer 2011;11:239-53. doi: 10.1038/nrc3007]Search in Google Scholar
[7. Joksic G, Leskovac A, Petrovic S. Modulation of radiationinduced damage by Serbian natural plant products: implications for radioprotection. In: Arora R, editor. Herbal radiomodulators: applications in medicine, homeland defence and space. Oxfordshire: CAB International; 2008. p. 67-82.10.1079/9781845933951.0067]Search in Google Scholar
[8. Moding EJ, Kastan MB, Kirsch DG. Strategies for optimizing the response of cancer and normal tissues to radiation. Nat Rev Drug Discov 2013;12:526-42. doi: 10.1038/nrd4003]Search in Google Scholar
[9. Burris HA, 3rd, Hurtig J. Radiation recall with anticancer agents. Oncologist 2010;15:1227-37. doi: 10.1634/ theoncologist.2009-0090]Search in Google Scholar
[10. Thomson NR, Crow MA, McGowan SJ, Cox A, Salmond GP. Biosynthesis of carbapenem antibiotic and prodigiosin pigment in Serratia is under quorum sensing control. Mol Microbiol 2000;36:539-56. doi: 10.1046/j.1365-2958. 2000.01872.x]Search in Google Scholar
[11. Hobbs G, Frazer CM, Gardner DCJ, Flett F, Oliver SG. Pigmented antibiotic production by Streptomyces coelicolor A3(2): kinetics and the influence of nutrients. J Gen Microbiol 1990;136:2291-6. doi: 10.1099/00221287-136-11-2291]Search in Google Scholar
[12. Kawasaki T, Sakurai F, Hayakawa Y. A prodigiosin from the roseophilin producer Streptomyces griseoviridis. J Nat Prod 2008;71:1265-7. doi: 10.1021/np7007494]Search in Google Scholar
[13. Nakamura A, Magae J, Tsuji RF, Yamasaki M, Nagai K. Suppression of cytotoxic T cell induction in vivo by prodigiosin 25-C. Transplantation 1989;47:1013-6. doi: 10.1097/00007890-198906000-00019]Search in Google Scholar
[14. Songia S, Mortellaro A, Taverna S, Fornasiero C, Scheiber EA, Erba E, Colotta F, Mantovani A, Isetta AM, Golay J. Characterization of the new immunosuppressive drug undecylprodigiosin in human lymphocytes: retinoblastoma protein, cyclin-dependent kinase-2, and cyclin-dependent kinase-4 as molecular targets. J Immunol 1997;158:3987-95. PMID: 910347010.4049/jimmunol.158.8.3987]Search in Google Scholar
[15. Tsuji RF, Magae J, Yamashita M, Nagai K, Yamasaki M. Immunomodulating properties of prodigiosin 25-C, an antibiotic which preferentially suppresses induction of cytotoxic T cells. J Antibiot (Tokyo) 1992;45:1295-302. PMID: 139985110.7164/antibiotics.45.12951399851]Search in Google Scholar
[16. Pandey R, Chander R, Sainis KB. Prodigiosins as anti cancer agents: living upto their name. Curr Pharm Design 2009;15:732-41. doi: 10.2174/138161209787582192]Search in Google Scholar
[17. Yamamoto C, Takemoto H, Kuno K, Yamamoto D, Nakai K, Baden T, Kamata K, Hirata H, Watanabe T, Inoue K. Cycloprodigiosin hydrochloride, a H+/Cl- symporter, induces apoptosis in human colon cancer cell lines in vitro. Oncol Rep 2001;8:821-4. PMID: 1141079110.3892/or.8.4.82111410791]Search in Google Scholar
[18. Yamamoto D, Kiyozuka Y, Uemura Y, Yamamoto C, Takemoto H, Hirata H, Tanaka K, Hioki K, Tsubura A. Cycloprodigiosin hydrochloride, a H+/Cl- symporter, induces apoptosis in human breast cancer cell lines. J Cancer Res Clin Oncol 2000;126:191-7. doi: 10.1007/s004320050032]Search in Google Scholar
[19. Chang CC, Chen WC, Ho TF, Wu HS, Wei YH. Development of natural anti-tumor drugs by microorganisms. J Biosci Bioeng 2011;111:501-11. doi: 10.1016/j.jbiosc.2010.12.026]Search in Google Scholar
[20. Ho TF, Ma CJ, Lu CH, Tsai YT, Wei YH, Chang JS, Lai JK, Cheuh PJ, Yeh CT, Tang PC, Tsai Chang J, Ko JL, Liu FS, Yen HE, Chang CC. Undecylprodigiosin selectively induces apoptosis in human breast carcinoma cells independent of p53. Toxicol Appl Pharmacol 2007;225:318-28. doi: 10.1016/j.taap.2007.08.007]Search in Google Scholar
[21. Liu P, Wang YY, Qi X, Gu Q, Geng M, Li J. Undecylprodigiosin induced apoptosis in P388 cancer cells is associated with its binding to ribosome. PLoS One 2013;8:e65381. doi: 10.1371/ journal.pone.0065381]Search in Google Scholar
[22. Nikodinovic-Runic J, Mojic M, Kang Y, Maksimovic-Ivanic D, Mijatovic S, Vasiljevic B, Stamenkovic VR, Senerovic L. Undecylprodigiosin conjugated monodisperse gold nanoparticles efficiently cause apoptosis in colon cancer cells in vitro. J Mater Chem B. 2014;2:3271-81. doi: 10.1039/ C4TB00300D]Search in Google Scholar
[23. Stankovic N, Senerovic L, Ilic-Tomic T, Vasiljevic B, Nikodinovic-Runic J. Properties and applications of undecylprodigiosin and other bacterial prodigiosins. Appl Microbiol Biotechnol 2014;98:3841-58. doi: 10.1007/ s00253-014-5590-1]Search in Google Scholar
[24. Stankovic N, Radulovic V, Petkovic M, Vuckovic I, Jadranin M, Vasiljevic B, Nikodinovic-Runic J. Streptomyces sp. JS520 produces exceptionally high quantities of undecylprodigiosin with antibacterial, antioxidative, and UV-protective properties. Appl Microbiol Biotechnol 2012;96:1217-31. doi: 10.1007/s00253-012-4237-3]Search in Google Scholar
[25. Leiros M, Alonso E, Sanchez JA, Rateb ME, Ebel R, Houssen WE, Jaspars M, Alfonso A, Botana LM. Mitigation of ROS insults by Streptomyces secondary metabolites in primary cortical neurons. ACS Chem Neurosci 2014;5:71-80. doi: 10.1021/cn4001878]Search in Google Scholar
[26. Boric M, Danevcic T, Stopar D. Prodigiosin from Vibrio sp. DSM 14379; a new UV-protective pigment. Microb Ecol 2011;62:528-36. doi: 10.1007/s00248-011-9857-0]Search in Google Scholar
[27. Law on health care. Official Gazette of the Republic of Serbia. Parliament of the Republic of Serbia. 2005. 107:112-161.]Search in Google Scholar
[28. Shukla S, Anjaria K, Bhat N, Shirsath K, Sreedevi B. Effect of caffeine on radiation induced micronuclei in human lymphocytes. Radiat Protect Environ 2010;33:195-8 [displayed 11 January 2017]. Available at http://www.rpe.org.in/article.asp?issn=0972-0464;year=2010;volume=33;issue=4;spage=195;epage=198;aulast=Shukla]Search in Google Scholar
[29. Fenech M. The cytokinesis-block micronucleus technique: a detailed description of the method and its application to genotoxicity studies in human populations. Mutat Res 1993;285:35-44. doi: 10.1016/0027-5107(93)90049-L]Search in Google Scholar
[30. Surralles J, Xamena N, Creus A, Marcos R. The suitability of the micronucleus assay in human lymphocytes as a new biomarker of excision repair. Mutat Res 1995;342:43-59. doi: 10.1016/0165-1218(95)90089-6]Search in Google Scholar
[31. Aebi H. Catalase. In: Bergmeyer HU, editor. Methods of enzymatic analysis. Weinheim: Verlag Chemie; 1974. p. 673-6.10.1016/B978-0-12-091302-2.50032-3]Search in Google Scholar
[32. Aruoma OI, Halliwell B, Laughton MJ, Quinlan GJ, Gutteridge JM. The mechanism of initiation of lipid peroxidation. Evidence against a requirement for an iron(II)- iron(III) complex. Biochem J 1989;258:617-20. doi: 10.1042/ bj2580617]Search in Google Scholar
[33. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-75. PMID: 1490771310.1016/S0021-9258(19)52451-6]Search in Google Scholar
[34. Baskar R, Lee KA, Yeo R, Yeoh KW. Cancer and radiation therapy: current advances and future directions. Int J Med Sci 2012;9:193-9. doi: 10.7150/ijms.3635]Search in Google Scholar
[35. Halliwell B, Gutteridge J. Free Radicals in Biology and Medicine. 4 ed. Oxford: Oxford University Press; 2007.]Search in Google Scholar
[36. Azzam EI, Jay-Gerin JP, Pain D. Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury. Cancer Lett 2012;327:48-60. doi: 10.1016/j.canlet.2011.12.012]Search in Google Scholar
[37. Roninson IB, Broude EV, Chang B-D. If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells. Drug Resist Updat 2001;4:303-13. doi: 10.1054/drup.2001.0213]Search in Google Scholar
[38. Vakifahmetoglu H, Olsson M, Zhivotovsky B. Death through a tragedy: mitotic catastrophe. Cell Death Differ 2008;15:1153-62. doi: 10.1038/cdd.2008.47]Search in Google Scholar
[39. Gupte A, Mumper RJ. Elevated copper and oxidative stress in cancer cells as a target for cancer treatment. Cancer Treat Rev 2009;35:32-46. doi: 10.1016/j.ctrv.2008.07.004]Search in Google Scholar
[40. Dröge W. Free radicals in the physiological control of cell function. Physiol Rev 2002;82:47-95. doi: 10.1152/ physrev.00018.2001]Search in Google Scholar
[41. Szatrowski TP, Nathan CF. Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res 1991;51:794-8. PMID: 1846317 ]Search in Google Scholar