<abstract xmlns="http://www.w3.org/1999/xhtml"><p>A nutritional placebo-controlled study was performed in Wistar rats in order to investigate the effects of 5-weeks aronia juice consumption towards fatty acid (FA) composition of phospholipids in the plasma and liver, as well as plasma glucose (Glu) and cholesterol levels. The animals were divided into 3 groups of 8 animals each, and randomized to receive either the full polyphenol dose of <italic>Aronia melanocarpa</italic> juice (AMJ), 4 times less polyphenol dose (¼-AMJ) or polyphenol-lacking placebo beverage (PLB). Each group of 8 male adult Wistar rats received the liquid <italic>ad libitum.</italic> AMJ decreased the levels of low-density lipoprotein (LDL) (P &lt; 0.05) vs. PLB. AMJ increased dihomo-γ-linoleic acid (DGLA, 20:3n-6) (P &lt; 0.05) and decreased arachidonic acid content (AA, 20:4n-6) (P &lt; 0.05) vs. PLB in liver phospholipids. AMJ significantly increased monounsaturated fatty acids (MUFA) levels both in the liver (P &lt; 0.05) and plasma (P &lt; 0.05). Both aronia juice doses elevated the levels of beneficial n-3 polyunsaturated fatty acids (PUFA) in the plasma and liver. There was a dose-dependent, significant increase (P &lt; 0.001) in cis-vaccenic acid (VA, 18:1n-7) in phospholipids in the plasma and liver. Our results indicate favorable effects of aronia juice intake on lipid parameters in Wistar rats. These findings suggest the potential of aronia dietary intake in cardiometabolic diseases primary prevention strategies in the human population.</p></abstract>

A nutritional placebo-controlled study was performed in Wistar rats in order to investigate the effects of 5-weeks aronia juice consumption towards fatty acid (FA) composition of phospholipids in the plasma and liver, as well as plasma glucose (Glu) and cholesterol levels. The animals were divided into 3 groups of 8 animals each, and randomized to receive either the full polyphenol dose of Aronia melanocarpa juice (AMJ), 4 times less polyphenol dose (¼-AMJ) or polyphenol-lacking placebo beverage (PLB). Each group of 8 male adult Wistar rats received the liquid ad libitum. AMJ decreased the levels of low-density lipoprotein (LDL) (P < 0.05) vs. PLB. AMJ increased dihomo-γ-linoleic acid (DGLA, 20:3n-6) (P < 0.05) and decreased arachidonic acid content (AA, 20:4n-6) (P < 0.05) vs. PLB in liver phospholipids. AMJ significantly increased monounsaturated fatty acids (MUFA) levels both in the liver (P < 0.05) and plasma (P < 0.05). Both aronia juice doses elevated the levels of beneficial n-3 polyunsaturated fatty acids (PUFA) in the plasma and liver. There was a dose-dependent, significant increase (P < 0.001) in cis-vaccenic acid (VA, 18:1n-7) in phospholipids in the plasma and liver. Our results indicate favorable effects of aronia juice intake on lipid parameters in Wistar rats. These findings suggest the potential of aronia dietary intake in cardiometabolic diseases primary prevention strategies in the human population.

Effects of <italic>Aronia melanocarpa</italic> juice on plasma and liver phospholipid fatty acid composition in Wistar rats

Center of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade; 11000 Belgrade,

Institute for Biological Research “Siniša Stanković“, University of Belgrade; 11000 Belgrade,

Acta Veterinaria

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Effects of  juice on plasma and liver phospholipid fatty acid composition in Wistar rats

A nutritional placebo-controlled study was performed in Wistar rats in order to investigate the effects of 5-weeks aronia juice consumption towards fatty acid...

Effects of Aronia melanocarpa juice on plasma and liver phospholipid fatty acid composition in Wistar rats

Publicado en línea: 30 mar 2017

Páginas: 107 - 120

Recibido: 20 jul 2016

Aceptado: 29 dic 2016

DOI: https://doi.org/10.1515/acve-2017-0010

Palabras clave
chokeberry, polyphenols, low-density lipoprotein, arachidonic acid, monounsaturated fatty acids

© 2017 Zec Manja et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Effects of Aronia melanocarpa juice on plasma and liver phospholipid fatty acid composition in Wistar rats

Publicado en línea: 30 mar 2017

Páginas: 107 - 120

Recibido: 20 jul 2016

Aceptado: 29 dic 2016

DOI: https://doi.org/10.1515/acve-2017-0010

Palabras clavechokeberry, polyphenols, low-density lipoprotein, arachidonic acid, monounsaturated fatty acids

© 2017 Zec Manja et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Palabras clave
chokeberry, polyphenols, low-density lipoprotein, arachidonic acid, monounsaturated fatty acids