<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Patients tend to prevent hypoglycemia by excessive saccharide intake leading to poorer glycemic control with potentially fatal consequences. This problem could be resolved by means of pellets with glucose release delayed by 120–360 min as a compensation of the antidiabetic drug peak effect. No glucose is released before; hence there is no risk of hyperglycemia and secondary complications. The pellets contain glucose in combination with an osmotically active ingredient and are coated with an ethylcellulose dispersion, which forms an insoluble semipermeable membrane and ensures delayed release. The release of glucose was assessed using dissolution and high-performance liquid chromatography. Dissolution profiles indicated the possibility of achieving the requested lag time using a combination of adequate compositions and coating concentrations. Lag times of 60, 240 and 360 min were achieved. The sample containing carboxymethyl starch was found to be most suitable for the intent of this work.</p></abstract>

Patients tend to prevent hypoglycemia by excessive saccharide intake leading to poorer glycemic control with potentially fatal consequences. This problem could be resolved by means of pellets with glucose release delayed by 120–360 min as a compensation of the antidiabetic drug peak effect. No glucose is released before; hence there is no risk of hyperglycemia and secondary complications. The pellets contain glucose in combination with an osmotically active ingredient and are coated with an ethylcellulose dispersion, which forms an insoluble semipermeable membrane and ensures delayed release. The release of glucose was assessed using dissolution and high-performance liquid chromatography. Dissolution profiles indicated the possibility of achieving the requested lag time using a combination of adequate compositions and coating concentrations. Lag times of 60, 240 and 360 min were achieved. The sample containing carboxymethyl starch was found to be most suitable for the intent of this work.

Coated pellets with delayed-release glucose for prevention of hypoglycemic episodes

Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, 612 00 Brno, Czech Republic

University Hospital, Department of Pediatrics, 500 05 Hradec Králové, Czech Republic

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Patients tend to prevent hypoglycemia by excessive saccharide intake leading to poorer glycemic control with potentially fatal consequences. This problem could...

Coated pellets with delayed-release glucose for prevention of hypoglycemic episodes

Publicado en línea: 28 may 2016

Páginas: 257 - 267

Aceptado: 17 dic 2015

DOI: https://doi.org/10.1515/acph-2016-0017

Palabras clave
hypoglycemia, diabetes mellitus, pellets, delayed release, glucose, pellet evaluation

© 2016 Dana Sabadková et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Coated pellets with delayed-release glucose for prevention of hypoglycemic episodes

Publicado en línea: 28 may 2016

Páginas: 257 - 267

Aceptado: 17 dic 2015

DOI: https://doi.org/10.1515/acph-2016-0017

Palabras clavehypoglycemia, diabetes mellitus, pellets, delayed release, glucose, pellet evaluation

© 2016 Dana Sabadková et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Palabras clave
hypoglycemia, diabetes mellitus, pellets, delayed release, glucose, pellet evaluation