<abstract xmlns="http://www.w3.org/1999/xhtml"> Resveratrol (RSV) is one of the polyphenols - metabolites common in plants,however it does not occur in animals. It occurs mainly in grape skin (Vitisvinifera), peanuts (Arachis hypogeal) and in the roots of (Polygonumcupidatum) a traditional Chinese curative plant.RSV has a preventive property against the most serious diseases of modern world such as cancer, neurodegenerative diseases and cardiovascular diseases. Due to pleiotropy, RSV is currently the main object of many research teams′ interest, which is shown by the significant number of publications devoted to this subject.Animal and human conducted studies have shown very low bioavailability of RSV (approx. 2%), which is the result of rapid biotransformation to sulphate and to a lesser extent, to the glucuronide conjugates as well. The studies on the improvement of RSV bioavailability, which have beencarried out for many years, have contributed to the synthesis of the analogues of more chemopreventive and more desirable pharmacokinetic properties. In order to enhance antiproliferative activity and RSV bioavailability, series of methyl analogues were synthesized and this will be described later in more detail. An example of such a derivative is DMU-212 (3,4,4’5-tetramethoxystilbene).</abstract>

Resveratrol (RSV) is one of the polyphenols - metabolites common in plants,however it does not occur in animals. It occurs mainly in grape skin (Vitisvinifera), peanuts (Arachis hypogeal) and in the roots of (Polygonumcupidatum) a traditional Chinese curative plant.RSV has a preventive property against the most serious diseases of modern world such as cancer, neurodegenerative diseases and cardiovascular diseases. Due to pleiotropy, RSV is currently the main object of many research teams′ interest, which is shown by the significant number of publications devoted to this subject.Animal and human conducted studies have shown very low bioavailability of RSV (approx. 2%), which is the result of rapid biotransformation to sulphate and to a lesser extent, to the glucuronide conjugates as well. The studies on the improvement of RSV bioavailability, which have beencarried out for many years, have contributed to the synthesis of the analogues of more chemopreventive and more desirable pharmacokinetic properties. In order to enhance antiproliferative activity and RSV bioavailability, series of methyl analogues were synthesized and this will be described later in more detail. An example of such a derivative is DMU-212 (3,4,4’5-tetramethoxystilbene).

Resveratrol and Its Analogues – Is It a New Strategy of Anticancer Therapy?

Department of Anatomy, Poznan University of Medical Sciences, Poznan,

Department of Obstetrics and Gynecology, University Hospital and Masaryk University, Brno,

Department of Anatomy, Poznan University of Medical Sciences, Poznan, Poland

Department of Histology and Embryology, Poznan University of Medical Sciences, Poznan,

Medical Journal of Cell Biology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Resveratrol and Its Analogues \u2013 Is It a New Strategy of Anticancer Therapy?"}

Resveratrol (RSV) is one of the polyphenols - metabolites common in plants,however it does not occur in animals. It occurs mainly in grape skin...

Resveratrol and Its Analogues – Is It a New Strategy of Anticancer Therapy?

Publicado en línea: 26 abr 2017

Páginas: 32 - 42

DOI: https://doi.org/10.1515/acb-2017-0003

Palabras clave
resveratrol, the methylated resveratrol analogues, apoptosis, cytotoxicity

© by Bartosz Kempisty

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Resveratrol and Its Analogues – Is It a New Strategy of Anticancer Therapy?

Publicado en línea: 26 abr 2017

Páginas: 32 - 42

DOI: https://doi.org/10.1515/acb-2017-0003

Palabras claveresveratrol, the methylated resveratrol analogues, apoptosis, cytotoxicity

© by Bartosz Kempisty

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Palabras clave
resveratrol, the methylated resveratrol analogues, apoptosis, cytotoxicity