Prevalence and time course of elevated serum levels of liver enzymes in otherwise healthy Thai infants with breast milk jaundice: a cohort study
, y | 04 ago 2020
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Article Category: Brief communication (original)
Publicado en línea: 04 ago 2020
Páginas: 67 - 73
DOI: https://doi.org/10.1515/abm-2020-0010
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© 2020 Pirarat Kotcharit et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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![Kaplan–Meier survival curves to estimate the median time for elevated serum levels of liver enzymes and total bilirubin (TB) to normalize.(A) Aspartate aminotransferase (AST): 240 days (95% confidence interval [CI], 139.0 to 340.9); (B) alanine aminotransferase (ALT): 291 days (95% CI, 109.8 to 472.2); (C) alkaline phosphatase (ALP): 184 days (95% CI, 4.4 to 363.6); (D) γ-glutamyl transferase (GGT): 63 days (95% CI, 61.44 to 64.6); and (E) TB: 120 days (95% CI, 74.6 to 164.5).](https://sciendo-parsed.s3.eu-central-1.amazonaws.com/647067dc83f1392090d68d5f/j_abm-2020-0010_fig_002.jpg?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20240722T163957Z&X-Amz-SignedHeaders=host&X-Amz-Expires=18000&X-Amz-Credential=AKIA6AP2G7AKP25APDM2%2F20240722%2Feu-central-1%2Fs3%2Faws4_request&X-Amz-Signature=6a06e309fbea139d4d26f5199010bb8e1e95f6d47a7f24cf35bed9e020b9f812)
Demographic variables and differences between groups of infants with normal and elevated liver enzymes at the first presentation
| Sex | |||
| Male | 8 | 18 | 0.39 |
| Female | 7 | 9 | |
| Gestational age (weeks) | |||
| 37 | 2 | 8 | 0.59 |
| 38 | 9 | 12 | |
| 39 | 3 | 3 | |
| 40 | 1 | 3 | |
| >40 | 0 | 1 | |
| Birth weight (g) | |||
| <2500 | 1 | 0 | 0.43 |
| 2501–3000 | 4 | 11 | |
| 3001–3500 | 9 | 13 | |
| >3500 | 1 | 3 | |
| Mode of delivery | |||
| Normal delivery | 6 | 13 | 0.61 |
| Cesarean section | 9 | 14 | |
| Liver enzyme (mean ± standard deviation) | |||
| AST (U/L) | 24.0–69.0 (35.6 ± 11.3) | 22.0–184.0 (50.4 ± 33.1) | 0.103 |
| ALT (U/L) | 10.0–33.0 (17.4 ± 6.2) | 10.0–56.0 (25.2 ± 13.2) | 0.013 |
| ALP (U/L) | 139.0–479.0 (262.5 ± 8.0) | 131.0–546.0 (320.8 ± 105.8) | 0.096 |
| GGT (U/L) | 57.0–124.0 (94.0 ± 23.6) | 55.0–352.0 (204.8 ± 75.8) | <0.001 |
Comparison of serum levels of liver enzymes between participants who completed the study and were lost to follow up in the group with elevated liver enzyme levels
| Completed | 55.0–341.0 (196.7 ± 90.7) | 13.0–55.0 (27.5 ± 12.3) | 27.0–109.0 (51.8 ± 21.9) | 137.0–513.0 (319.7 ± 105.5) |
| Lost to follow up | 156.0–352.0 (212.2 ± 62.9) | 10.0–56.0 (23.1 ± 14.2) | 22.0–184.0 (49.1 ± 41.8) | 131.0–546.0 (321.8 ± 110.4) |
| 0.66 | 0.39 | 0.84 | 0.96 | |
Total bilirubin level for each group at the first presentation and at age 2 months
| Normal liver enzymes | 14.1 ± 4.1 | 0.76 | 2.2 ± 1.7 | 0.09 |
| Elevated liver enzymes | 14.4 ± 2.7 | 4.1 ± 3.5 | ||