Reference/ | Present | [2] | [3] | [4] | [7] | |||
---|---|---|---|---|---|---|---|---|
Characteristic | case (2016) | |||||||
Age (years) | 42 | 27 | 17 | 15 | 7 | 15 | 7 | |
Sex | Female | Male | Female | Female | Female | Female | Male | |
Presenting symptom | Fever | Fever | Fever | Fever | Fever | Fever | Fever | |
(7 days) | (2 days) | (7 days) | (4 days) | (7 days) | (14 days) | (3 days) | ||
Malaria infection | P.f | P.f | P.f | P.v. + P.f | P.v. + P.f | P.f | P.v | |
Anti-malarial | Artesunate | Antimalarial | Artemether/lumefantrine | Artesunate i.v | Artesunate | Artesunate i.v | Chloroquine | |
regimen (duration) | i.v. (7 days) | treatment | (6 days) and then artesunate | (5 days) | i.v. (5 days) + | (N/A) | (2 days) + primaquine | |
(unknown) | (2 days) | mefloquine | (14 days) | |||||
Other antibiotic | Ceftriaxone | N/A | Ceftriaxone, metronidazole | Ceftriaxone | Ceftriaxone | Ceftriaxone | NEG | |
treatment | gentamicin, piperacillin | doxycycline | ||||||
ciprofloxacin | ||||||||
Onset of AIHA (days | 12th | 1st | 14th | 9th | 7th | 11th | 2nd | |
after antimalarial | ||||||||
treatment) | ||||||||
Diagnostic method | ||||||||
Hemoglobin | 3.5 | Hct. 15.2% | 4.6 | 4.8 | 5.1 | 4.5 | 5.2 | |
(g/dL) | ||||||||
Coombs test | POS | NEG | POS | NEG | N/A | NEG | POS | |
LDH (U/L) | High | N/A | High | High | High | High | N/A | |
Identify cause | ||||||||
ANA | NEG | N/A | NEG | NEG | POS | NEG | N/A | |
CA test POS | CA test POS | |||||||
Antibody | Autoanti-E | N/A | N/A | N/A | N/A | N/A | Autoanti-I | |
identification | Autoanti-I | |||||||
Specific treatment | Predni | No | Methylprednisolone | Prednisolone | Prednisolone | Prednisolone | Prednisolone | |
for AIHA (dosage) | solone | (60 mg/day × 7 days) | (1 MKD) | (N/A) | (0.5 MKD) | (1 MKD) | ||
(1 MKD) | Prednisolone (1 MKD) | |||||||
PRC transfusion | 1 | 0 | 0 | 2 | 3 | 0 | 1 | |
(unit) | ||||||||
Duration of recovery | ||||||||
Malaria infection | 5 | N/A | N/A | N/A | 7 | 11 | 2 | |
(days) | ||||||||
AIHA, anemia (days) | 8 | 4 | 7 | 28 | 28 | 56 | 10 | |
Stop prednisolone | 30 | N/A | 60 | 42 | 28 | N/A | 56 | |
(days) |