Journal of Biomedical and Clinical Research

The article presents a detailed survey of recent publications in the literature concerning clinical expertise, existing guidelines, and differing opinions on Fluoropyrimidine chemotherapy-related toxicity and the implication of Dihydropyrimidine dehydrogenase (DPD) screening aiming to prevent severe 5-Fluorouracil-induced adverse drug reactions. The first section provides information on the mechanism of action, clinical application, pharmacokinetics and pharmacodynamics, and toxicity and adverse reactions of 5-Fluorouracil, Capecitabine, Floxuridine, and Flucytosine.

Summary

SofiaMed University Multiprofile Hospital for Active Treatment

Keywords

<article-title>Toxic and Adverse Effects of Chemotherapy with 5-Fluoropyrimidine Drugs. Could Dihydropyrimidine Dehydrogenase Enzyme Screening Serve as a Prerequisite to Successful Chemotherapy?</article-title>

Toxic and Adverse Effects of Chemotherapy with 5-Fluoropyrimidine Drugs. Could Dihydropyrimidine Dehydrogenase Enzyme Screening Serve as a Prerequisite to Successful Chemotherapy?

Surgical treatment of rectal cancer is still difficult even in big centers. The limited pelvic space, problematic operative exposure, complex surgeries with more common anastomotic complications make the results unsatisfying. After the concept of total mesorectal excision (TME) was introduced by Heald, the results have improved dramatically. Advances in technology added further excitement about awaited promising results. Surgeons tried to apply all new methods to search for the best treatment: – atraumatic, painless, safe, with low recurrence rates, fast recovery, with an acceptable price, and easy to learn or teach. Robotic-assisted laparoscopic surgery (RALS) was introduced to overcome the limitations of conventional laparoscopic and open surgery and improve on their main advantages.

Dr. Georgi Stranski University Hospital - Pleven

Medical University – Pleven Department of Surgical Propaedeutics, Medical University – Pleven

<article-title>Robotic-Assisted Laparoscopic Surgery for Rectal Cancer (RALS): A Review of the Literature</article-title>

Robotic-Assisted Laparoscopic Surgery for Rectal Cancer (RALS): A Review of the Literature

Squamous cell carcinoma is the cause in most cases of cervical cancer. A very unusual subtype of squamous cell carcinoma is lymphoepithelioma-like carcinoma, found in less than 1% of the neoplasm processes in the uterine cervix. Histologically it looks like a large nest of big-sized tumor cells with large vascular nuclei. Immunohistochemical markers used for LELC are p63, p16, human leukocyte antigen-D related (HLA-DR), and B-cell lymphoma 2. Even though it has aggressive morphological features, it has a better prognosis than most carcinoma cases of the uterine cervix. The condition is treatable, with a hysterectomy and bilateral salpingo-oophorectomy as the most common method. There are rare cases of pelvic lymph node dissection reported in the literature.

<article-title>Presence of EBV and HPV Infection in Lymphoepithelioma-Like Carcinoma in the Uterine Cervix</article-title>

Presence of EBV and HPV Infection in Lymphoepithelioma-Like Carcinoma in the Uterine Cervix

An increased risk of developing Alzheimer’s disease (AD) exists in patients with a history of depression. In the present study, we demonstrated that chronic agomelatine intraperitoneal treatment, at a dose of 40 mg/ kg for 21 days, starting one month after inducing AD by intracerebroventricular injection of amyloid-beta (Aβ) corrected anhedonia, decreased anxiety, and showed a potential to mitigate working memory errors during the last session in a radial arm maze. Altogether, our findings suggest that chronic agomelatine administration treatment could alleviate the burden of AD and may be considered a promising therapeutic approach to some adverse symptoms caused by the disease.

<article-title>Beneficial Influence of Agomelatine Treatment on Behavioral Impairments in AΒ-Induced Rat Model of Alzheimer’s Disease</article-title>

Beneficial Influence of Agomelatine Treatment on Behavioral Impairments in AΒ-Induced Rat Model of Alzheimer’s Disease

A survey was performed to evaluate patient exposure after a procedure for the CT X-ray tube’s emergency warm-up, with the patient positioned on the table within the CT gantry. Three CT units, situated in three different University hospitals, were included in the survey. The evaluation was performed with AGFA personal monitoring films to visualize the results and discuss them with the radiographers who operate the systems. Additional measurements were performed with the RaySafe X2 system to demonstrate the presence of exposure. The air kerma resulting from implementing the warm-up protocol was evaluated to be higher than 112 μGy, 409 μGy, and 807 μGy for each of the CT units. Those values were underestimated because of the dosimetry equipment used and the methodology. A discussion between medical staff, engineers, and medical physicist was initiated. The practice with unnecessary patient exposure was terminated.

University Hospital Aleksandrovska -Sofia

<article-title>Evaluation of Patient Exposure After an Emergency Warm-Up of the CT X-Ray Tube</article-title>

Evaluation of Patient Exposure After an Emergency Warm-Up of the CT X-Ray Tube

{"article-title":"Evaluation of Patient Exposure After an Emergency Warm-Up of the CT X-Ray Tube"}

The study presents the outcomes from platelet-rich plasma (PRP) application in treating acute and potentially problematic skin wounds from 2009 to 2016. Fifty-six hospitalized patients with acute skin wounds were divided into two groups: an experimental group of 30 patients treated with platelet-rich plasma and 26 controls with similar wounds, treated by conventional methods. After platelet-rich plasma treatment of 30 acute and potentially problematic wounds in the Experimental Group patients, 29 (96.7%) of the wounds healed for 16 weeks on average. After applying conventional treatment with surgical wound debridement, of the 26 acute, potentially problematic wounds in the controls, only 2 (7.6%) healed. Since acute and potentially problematic wounds are very likely to become chronic and difficult to heal, we recommend PRP application as a preventive treatment in patients at risk.

<article-title>Prevention and Treatment of Potentially Problematic Acute Wounds to Achieve Full Recovery by Using Platelet-Rich Plasma: Research Results</article-title>

Prevention and Treatment of Potentially Problematic Acute Wounds to Achieve Full Recovery by Using Platelet-Rich Plasma: Research Results

Preterm birth is the most common cause of perinatal morbidity and mortality worldwide. The routine method for predicting premature birth is the measurement of the cervical length. However, to make a better and more precise prognosis, the cervicovaginal fluid (CVF) was widely inspected through many studies. Its content is used nowadays as a diagnostic method for different conditions. One of the clinical biomarkers used to predict preterm labour in the CVF is the phosphorylated insulin-like growth factor binding protein-1 (pIGFBP-1). This study aimed to evaluate the accuracy of pIGFBP-1 as a predictor of preterm labour when used with cervical biometrics.

<article-title>Accuracy of Phosphorylated Insulin-Like Growth Factor Binding Protein-1 in Predicting Preterm Labour</article-title>

Accuracy of Phosphorylated Insulin-Like Growth Factor Binding Protein-1 in Predicting Preterm Labour

We present tooth extraction in a patient treated with bisphosphonates (BPs) for cancer and at risk of osteonecrosis of the jaw. The administration of platelet-rich fibrin (PRF) is an innovative method of promoting wound healing that allows hermetic closure at the surgical site after extraction without mucoperiosteal flaps or periosteal release sections. Here, we describe the case of a 60-year-old man who had osteonecrosis of the upper jaw and underwent surgery for prostate cancer in 2012. In 2014, bone metastases were detected, and the patient was treated with Xgeva and Zometa: a two-year therapy with Xgeva, followed by treatment with Zometa. In 2018, after extraction of a tooth in the upper right jaw, a healing wound of extraction and stripping of the maxillary bone occurred. The patient was admitted for hospital treatment and underwent surgery to remove the osteonecrotic lesion, sequester and administer PRF (platelet-rich fibrin), and sew tightly. As a result of the treatment, complete re-epithelialization of the wound without infection occurred. Generally, in more invasive surgical procedures, the use of PRF to close the wells after extraction in patients receiving BP appears to be a promising alternative. Additional clinical trials will be essential t to clarify the effectiveness of PRF in preventing BP-related osteonecrosis after tooth extraction.

Department of Imaging Diagnostics, Dental Allergology and Physical Therapy, Faculty of Dental Medicine

Department of Epidemiology and Disaster Medicine, Faculty of Public Health

Department of Oral Surgery, Faculty of Dental Medicine

<article-title>Use of Platelet-Rich Fibrin for Jaw Osteonecrosis: A Case Report</article-title>

Use of Platelet-Rich Fibrin for Jaw Osteonecrosis: A Case Report

{"article-title":"Use of Platelet-Rich Fibrin for Jaw Osteonecrosis: A Case Report"}

Frequent mood changes are found in premenstrual dysphoric disorder (PMDD) as well as in bipolar affective disorder (BAD). The differential diagnosis is difficult because both conditions share some other common symptoms.

Sveti Naum University Hospital for Active Treatment in Neurology and Psychiatry

Department of Psychiatry and Medical Psychology

<article-title>A Case Report of a Woman with Premenstrual Dysphoric Disorder Misdiagnosed as Having Bipolar Affective Disorder</article-title>

A Case Report of a Woman with Premenstrual Dysphoric Disorder Misdiagnosed as Having Bipolar Affective Disorder

Brain abscess in children is a rare and particularly severe complication of acute otitis media/Chronic suppurative otitis media (CSOM). Presenting a child with brain abscess, which was developed as a pre-surgical complication of CSOM with cholesteatoma. Visualization of the abscess on a 3-D Sectra Visualization table was performed.

<article-title>Sectra 3 D Human Body Visualization Table Use in Brain Abscess Diagnostics in a Child: A Case Report</article-title>

Sectra 3 D Human Body Visualization Table Use in Brain Abscess Diagnostics in a Child: A Case Report

<!doctype html public "-//w3c//dtd html 4.0 transitional//en"> <html><head> <meta http-equiv=content-type content="text/html; charset=iso-8859-1"> <meta content="mshtml 6.00.6000.17104" name=generator></head> <body> Journal of Biomedical and Clinical Research is covered by the following services: <UL><LI>Baidu Scholar</LI><LI>CABI (over 50 subsections)</LI><LI>Case</LI><LI>CNKI Scholar (China National Knowledge Infrastructure)</LI><LI>CNPIEC - cnpLINKer</LI><LI>Dimensions</LI><LI>EBSCO (relevant databases)</LI><LI>EBSCO Discovery Service</LI><LI>Google Scholar</LI><LI>Japan Science and Technology Agency (JST)</LI><LI>J-Gate</LI><LI>JournalTOCs</LI><LI>KESLI-NDSL (Korean National Discovery for Science Leaders)</LI><LI>Microsoft Academic</LI><LI>MyScienceWork</LI><LI>Naver Academic</LI><LI>Naviga (Softweco)</LI><LI>Primo Central (ExLibris)</LI><LI>ProQuest (relevant databases)</LI><LI>Publons</LI><LI>QOAM (Quality Open Access Market)</LI><LI>ReadCube</LI><LI>Semantic Scholar</LI><LI>Summon (ProQuest)</LI><LI>TDNet</LI><LI>Ulrich's Periodicals Directory/ulrichsweb</LI><LI>WanFang Data</LI><LI>WorldCat (OCLC)</LI></UL></body></html>

<!doctype html public "-//w3c//dtd html 4.0 transitional//en"> <html><head> <meta http-equiv=content-type content="text/html; charset=iso-8859-1"> <meta content="mshtml 6.00.6000.17104" name=generator></head> <body> Journal of Biomedical and Clinical Research ist in den folgenden Services indiziert: <UL><LI>Baidu Scholar</LI><LI>CABI (over 50 subsections)</LI><LI>Case</LI><LI>CNKI Scholar (China National Knowledge Infrastructure)</LI><LI>CNPIEC - cnpLINKer</LI><LI>Dimensions</LI><LI>EBSCO (relevant databases)</LI><LI>EBSCO Discovery Service</LI><LI>Google Scholar</LI><LI>Japan Science and Technology Agency (JST)</LI><LI>J-Gate</LI><LI>JournalTOCs</LI><LI>KESLI-NDSL (Korean National Discovery for Science Leaders)</LI><LI>Microsoft Academic</LI><LI>MyScienceWork</LI><LI>Naver Academic</LI><LI>Naviga (Softweco)</LI><LI>Primo Central (ExLibris)</LI><LI>ProQuest (relevant databases)</LI><LI>Publons</LI><LI>QOAM (Quality Open Access Market)</LI><LI>ReadCube</LI><LI>Semantic Scholar</LI><LI>Summon (ProQuest)</LI><LI>TDNet</LI><LI>Ulrich's Periodicals Directory/ulrichsweb</LI><LI>WanFang Data</LI><LI>WorldCat (OCLC)</LI></UL></body></html>

Editor-in-Chief Grigor Gortchev, MU Pleven, Bulgaria Co-Editor Slavcho Tomov, MU Pleven, Bulgaria Deputy/ Managing Editor Mariya Sredkova, MU Pleven, Bulgaria Editorial Board Asparuh Asparuhov, MU Pleven, Bulgaria Chavdar Balabanov, MU Pleven, Bulgaria 　 Petyo Bochev, MU Pleven, Bulgaria Tashko Deliyski, MU Pleven, Bulgaria 　 Silviya Aleksandrova-Yankulovska, MU Pleven, Bulgaria Dimitar Gospodinov, MU Pleven, Bulgaria 　 Emilyan Ivanov, MU Pleven, Bulgaria Yavor Ivanov, MU Pleven, Bulgaria 　 Vaniya Nedkova, MU Pleven, Bulgaria 　 Savelina Popovska, MU Pleven, Bulgaria 　 Jordan Popov, MU Pleven, Bulgaria 　 Dimitar Stoykov, MU Pleven, Bulgaria Mariya Simeonova, MU Pleven, Bulgaria 　 Alexander Valkov, MU Pleven, Bulgaria Plamen Bojinov, MU Pleven, Bulgaria Advisory Board Genka Bekyarova, MU Varna, Bulgaria Veselin Borisov, MU Sofia, Bulgaria 　 Yvon. Carpentier, ULB Bruxelles, Belgium 　 Raimund Jakesz, AKH Vienna, Austria Jorg Jerosh, Neuss, Germany 　 Ivan Lambev, MU Sofia, Bulgaria 　 Ivan Manchev, MU Stara Zagora, Bulgaria Pier P. Mariani, Rome, Italy 　 Evlogi Marinov, MU Pleven, Bulgaria Robert Mecham, St. Louis, Missouri, USA 　 Stewart Mennin, New Mexico, USA Ivan G. Mitov, Sofia, Bulgaria Gilbert Park, Cambridge, UK 　 Penka Perenovska, Sofia, Bulgaria Peter M. Schlag, Berlin, Deutschland 　 Emil Simeonov, Sofia, Bulgaria Svetla Torbova, Sofia, Bulgaria 　 Nicola Vassilev, Sofia, Bulgaria Carl R. Whitehouse, Weymouth, Dorset, UK 　 Jacques Winand, Bruxelles, Belgium Hans P. Zenner, Tubingen, Germany Editorial Office Assistant Editor Tsvetelin Lisaev, MU Pleven, Bulgaria Associated Editors Galya Stavreva, MU Pleven, Bulgaria Ivelina Yordanova , MU Pleven, Bulgaria Nadia Veleva, MU Pleven, Bulgaria Dobromir Dimitrov, MU Pleven, Bulgaria Statistical Editor Petkana Hristova, MU Pleven, Bulgaria Language Editor Yanka Tzvetanova , MU Pleven, Bulgaria Electronic Publishing Editor Pencho Tonchev, MU Pleven, Bulgaria Production Editor Silviya Emileva, MU Pleven, Bulgaria 　 Contact <A href="mailto:jbcr@mu-pleven.bg">jbcr@mu-pleven.bg</A> Publisher De Gruyter Poland Bogumiła Zuga 32A Str. 01-811 Warsaw, Poland T: +48 22 701 50 15

Two copies of the manuscripts (on one side of the paper only), written in English, accompanied by a CD (labeled with the file name) should be submitted to: Editorial Office of Journal of Biomedical and Clinical Research Medical University 1, St. Kliment Ohridski, Str. 5800 Pleven, Bulgaria Tel. +359 64 884 131 <A href="mailto:jbcr@mu-pleven.bg">jbcr@mu-pleven.bg</A>

<DIV align=justify> Journal of Biomedical and Clinical Research (JBCR) is a peer reviewed, multidisciplinary scientific journal of Medical University - Pleven, open to scientists from all fields of medicine and related areas. JBCR publishes reviews, original articles and communications in the field of biomedical, clinical, public health and health care research, medical education, case reports, written in English. JBCR is published two times per year. JBCR follows uniform requirements for manuscripts submitted to biomedical journals, developed by the International Committee of Medical Journal Editors (<A href="http://www.icmje.org/">www.ICMJE.org</A>). Rejection Rate <UL> <LI>35% </LI></UL> Similarity Check Plagiarism Screening System The editorial board is participating in a growing community of Similarity Check System's users in order to ensure that the content published is original and trustworthy. Similarity Check is a medium that allows for comprehensive manuscripts screening, aimed to eliminate plagiarism and provide a high standard and quality peer-review process. Detailed description of the Similarity Check System can be found at: <A href="https://www.crossref.org/services/similarity-check/">www.crossref.org/services/similarity-check/</A> </DIV>

Ausgaben

Zeitschriften und Ausgaben

Journal of Biomedical and Clinical Research

Suche

Volume 13 (2020): Issue 2 (December 2020)

Details zu Zeitschrift und Ausgabe

Suche

Artikel

Plan your remote conference with Sciendo