<abstract xmlns="http://www.w3.org/1999/xhtml">
This study delves into the comprehensive evaluation of phytochemicals extracted from Anvillea radiata, with a focus on their potential anti-inflammatory applications. High-performance liquid Chromatography analysis reveals the dominance of catechin in the aqueous extract, alongside other compounds such as syringic acid, 3,4-dihydroxybenzoic acid, and vanillic acid, as well as quercetin-3-β-D-glucoside and rutin in smaller quantities. An in vitro anti-inflammatory assay demonstrates the superior effectiveness of <italic>A. radiata</italic> aqueous extract at lower concentrations compared to Aspirin, raising possibilities for reduced side effects and enhanced cost-effectiveness. Drug-likeness predictions emphasize the potential of catechin, syringic acid, and vanillic acid for drug development due to their molecular characteristics. Toxicity risk assessment indicates that catechin, quercetin-3-β-D-glucoside, and rutin exhibit low toxicity risks and favorable drug-likeness properties. Molecular docking analysis highlights promising interactions between the identified compounds and crucial anti-inflammatory (COX-2, MPO, IL1β, IL6, and TNFα.) target proteins. Notably, catechin demonstrates a strong binding affinity to these proteins. Molecular dynamics simulations further support catechin’s potential, revealing significant deformability in complexes with COX-2 and MPO, indicating high structural flexibility. The variance map shows higher cumulative variances and the elastic network map yields satisfactory outcomes, further reinforcing the potential of <italic>A. radiata</italic> aqueous extract compounds, with catechin as a standout candidate for anti-inflammatory drug development.
</abstract>

Department of Environmental Sciences, Faculty of Nature and Life Sciences

Djillali LIABES University Sidi-Bel-Abbès

Department of Biology, Faculty of Sciences

Department of Natural and Life Sciences, Faculty of Sciences and Technology

Exploring the Anti-Inflammatory Potential of Phytochemicals from <italic>Anvillea radiata</italic>: <italic>In Vitro</italic> Assay, Molecular Docking, and Molecular Dynamics Simulations

<abstract xmlns="http://www.w3.org/1999/xhtml">
Rabbit feed in Algeria is still based exclusively on commercial pelleted diets, but the recent use of non-conventional ingredients in feed formulation is becoming more frequent, and several studies were carried out on the incorporation of local raw materials in rabbit feed worldwide. However, studies related to the incorporation of Jujube are nonexistent. In this context; this experimental trial assessed the impact of Jujube pulp on local populations’ rabbits’ hematological and biochemical parameters during three physiological stages: non-pregnancy, pregnancy, and lactation. 72 rabbits were divided into 18 groups of 04 rabbits each one, three groups of non-pregnant females fed 100 % commercial pelleted diet, three groups of non-pregnant females fed 50 % commercial pelleted diet with 50 % Jujube, three groups of pregnant females fed 100 % commercial pelleted diet, three groups of pregnant females fed 50 % commercial pelleted diet with 50 % Jujube, three groups of lactating females fed 100 % commercial pelleted diet, and three groups of lactating females fed 50 % commercial pelleted diet with 50 % Jujube. The levels of white blood cells (WBC), hemoglobin concentration (Hb), lymphocytes (L %), mean corpuscular volume (MCV) and Platelets (PLT) recorded in pregnant and lactating rabbits fed a diet incorporating Jujube were greater than those found in females fed 100 % commercial pelleted diet. The results revealed also that 79 % of the variations in ALP, 79 % in creatinine and 57 % in Tb expressed were related to variations in diet and physiological stage. The hematological and biochemical profile of the experimental animals indicated that Jujube is nutritionally appropriate without any deleterious effect on the female rabbits.
</abstract>

Department of Biology, Faculty of Nature and Life Sciences, University Hassiba Benbouali of Chlef

Faculty of Natural and Life Sciences and Earth Sciences

University Djilal Bounaama of Khemis Miliana

Department of Human Nutrition, Faculty of Nature and Life Sciences, University Hassiba Benbouali of Chlef

Faculty of Biological Sciences, University of Science and Technology Houari Boumédiène

Laboratory of Renewable Energy and Materials

Department of Chemistry, Faculty of Exact Sciences and Informatics, University Hassiba Benbouali of Chlef

Hematological and Biochemical Indices of a Local Rabbit Does Population Fed Diet Incorporated with Jujube Pulp (<italic>Ziziphus lotus</italic>)

<abstract xmlns="http://www.w3.org/1999/xhtml">
In the context of the restoration of the holm oak forest ecosystem, which has suffered damage from wildfires, and with the aim of reducing the wildfire risk, the primary threat to these natural habitats, this study seeks to establish a systematic approach to map areas at risk of forest fires. This approach relies on the use of remote sensing data, including Landsat 8 satellite images and digital elevation models using Geographic Information System (GIS). Factors influencing the ignition and spread of forest fires were assessed, including vegetation cover, topography, and human factors. A forest fire risk map has been created for the Holm oak forest in the Al Hassasna region (Saida province), enabling local authorities and forest managers to implement more effective fire prevention and management measures.
</abstract>

Laboratory of Water Resources and Environment

Department of Biology, Faculty of Science, University of Saida – Dr

Laboratory of Biotoxicology, Pharmacognosy and Biological Valorization of Plant (LBPVBP)

Faculty of Sciences, University of Saida- Dr Moulay Tahar

Fire Risk Mapping for Holm Oak Forests in El Hassasna Region as Part of the Ecosystem Restoration Programme

<abstract xmlns="http://www.w3.org/1999/xhtml">
The first step of the proteomic study is the extraction and the success of this technique was based mainly on the choice of the best extraction. The purpose of this study was to determine the simplest and lowest-cost method of total protein extraction. Initially, various extraction methods were performed for protein extraction from roots of <italic>Astragalus armatus</italic> Willd. The methods employed were extraction by RIPA buffer, hypotonic buffer and distilled water. After determination of protein concentration by Bradford method and SDS PAGE electrophoretic analysis, the quantity and quality of extracted proteins using different protocols from <italic>A. armatus</italic> were determined and compared. The protein yield of RIPA buffer method was higher than the yields of hypotonic buffer method and distilled water method. The best protein patterns were produced by RIPA buffer method. The extract obtained by RIPA buffer was the optimal protocol for protein extraction.
</abstract>

An Efficient Protein Extraction Method from <italic>Astragalus armatus</italic> Willd. Roots for Proteomic Analysis

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Advanced Research in Life Sciences

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Advanced Research in Life Sciences

Volume 8 (2024): Issue 1 (January 2024)

Exploring the Anti-Inflammatory Potential of Phytochemicals from Anvillea radiata: In Vitro Assay, Molecular Docking, and Molecular Dynamics Simulations

Hematological and Biochemical Indices of a Local Rabbit Does Population Fed Diet Incorporated with Jujube Pulp (Ziziphus lotus)

Fire Risk Mapping for Holm Oak Forests in El Hassasna Region as Part of the Ecosystem Restoration Programme

An Efficient Protein Extraction Method from Astragalus armatus Willd. Roots for Proteomic Analysis

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