<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Electrical impedance spectroscopy (EIS) allows for the study and characterization of tissue alterations and properties associated with the skin. Here, the potential application of EIS to estimate the thickness of the stratum corneum is explored in the form of a mathematical model for EIS, which is analyzed in the limit of 1 kHz and closed-form analytical solutions derived. These analytical expressions are verified with the numerical solution of the full set of equations and validated with an EIS study comprising 120 subjects: overall, good agreement is found in the frequency range 1-100 kHz, where the impedance is governed by the stratum corneum. Combining the closed-form expression for the thickness of the stratum corneum predicted by the model with the experimental EIS measurements, a distribution for the stratum corneum thickness of the subjects is found with a mean and standard deviation that agree well with reported stratum corneum thicknesses from other experimental techniques. This, in turn, suggests that EIS could be employed to measure the thickness of the stratum corneum with reasonable accuracy. In addition, the electrical properties relevant to EIS – conductivity and relative permittivity – of the stratum corneum can be estimated with the closed form expressions if the stratum corneum thickness is known.</p></abstract>

Electrical impedance spectroscopy (EIS) allows for the study and characterization of tissue alterations and properties associated with the skin. Here, the potential application of EIS to estimate the thickness of the stratum corneum is explored in the form of a mathematical model for EIS, which is analyzed in the limit of 1 kHz and closed-form analytical solutions derived. These analytical expressions are verified with the numerical solution of the full set of equations and validated with an EIS study comprising 120 subjects: overall, good agreement is found in the frequency range 1-100 kHz, where the impedance is governed by the stratum corneum. Combining the closed-form expression for the thickness of the stratum corneum predicted by the model with the experimental EIS measurements, a distribution for the stratum corneum thickness of the subjects is found with a mean and standard deviation that agree well with reported stratum corneum thicknesses from other experimental techniques. This, in turn, suggests that EIS could be employed to measure the thickness of the stratum corneum with reasonable accuracy. In addition, the electrical properties relevant to EIS – conductivity and relative permittivity – of the stratum corneum can be estimated with the closed form expressions if the stratum corneum thickness is known.

Estimating electrical properties and the thickness of skin with electrical impedance spectroscopy: Mathematical analysis and measurements

Journal of Electrical Bioimpedance

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Electrical impedance spectroscopy (EIS) allows for the study and characterization of tissue alterations and properties associated with the skin. Here, the...

Estimating electrical properties and the thickness of skin with electrical impedance spectroscopy: Mathematical analysis and measurements

Article Category: Articles

Online veröffentlicht: 22. Okt. 2012

Seitenbereich: 51 - 60

Eingereicht: 06. Sept. 2012

DOI: https://doi.org/10.5617/jeb.400

Schlüsselwörter
Dermis, electrical impedance, epidermis, mathematical model, stratum corneum

© 2012 U. Birgersson, E. Birgersson, S. Ollmar, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Estimating electrical properties and the thickness of skin with electrical impedance spectroscopy: Mathematical analysis and measurements

Article Category: Articles

Online veröffentlicht: 22. Okt. 2012

Seitenbereich: 51 - 60

Eingereicht: 06. Sept. 2012

DOI: https://doi.org/10.5617/jeb.400

SchlüsselwörterDermis, electrical impedance, epidermis, mathematical model, stratum corneum

© 2012 U. Birgersson, E. Birgersson, S. Ollmar, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Schlüsselwörter
Dermis, electrical impedance, epidermis, mathematical model, stratum corneum