[
Adkins I., M. Koberle, S. Grobner, E. Bohn, I.B. Autenrieth and S. Borgmann. 2007. Yersinia outer proteins E, H, P, and T differentially target the cytoskeleton and inhibit phagocytic capacity of dendritic cells. Int. J. Med. Microbiol. 297: 235–244.
]Search in Google Scholar
[
Aepfelbacher M. and J. Heesemann. 2001. Modulation of Rho GTPases and the actin cytoskeleton by Yersinia outer proteins (Yops). Int. J. Med. Microbiol. 291: 269–276.10.1078/1438-4221-0013011680787
]Search in Google Scholar
[
Amedei A., E. Niccolai, L. Marino and M.M. D’Elios. 2011. Role of immune response in Yersinia pestis infection. J. Infect. Dev. Ctries. 5(9): 628–639.
]Search in Google Scholar
[
Andor A., K. Trulzsch, M. Essler, A. Wiedemann, A. Roggen-Kamp, J. Heesemann and M. Aepfelbacher. 2001. YopE of Yersinia, a GAP for Rho-GTPases, selectively modulates Rac-dependent actin structures in endothelial cells. Cell Microbiol. 3: 301–310.
]Search in Google Scholar
[
Bahta M. and T.R. Burke. 2012. Yersinia pestis and approaches to targeting its outer protein H protein-tyrosine phosphatase (YopH). Curr. Med. Chem. 19(33): 5726–5734.
]Search in Google Scholar
[
Bergsbaken T., S.L. Fink and B.T. Cookson. 2009. Pyroptosis: host cell death and inflammation. Nat. Rev. Micro. 7: 99–109.10.1038/nrmicro2070291042319148178
]Search in Google Scholar
[
Bergsbaken T., S.L. Fink, A.B. den Hartigh, W.P. Loomis and B.T. Cookson. 2011. Coordinated host responses during pyroptosis: caspase-1-dependent lysosome exocytosis and inflammatory cytokine maturation. J. Immunol. 187: 2748–2754.10.4049/jimmunol.1100477366015021804020
]Search in Google Scholar
[
Bliska J.B. 2000. Yop effectors of Yersinia spp. and actin rearrangements. Trends. Microbiol. 8(5): 205–208.
]Search in Google Scholar
[
Bliska J.B. 2006. Yersinia inhibits host signaling by acetylating MAPK kinases. ACS. Chem. Biol. 1(6): 349–351.
]Search in Google Scholar
[
Brodsky I.E., N.W. Palm, S. Sadanand, M.B. Ryndak, F.S. Sutter-wala, R.A. Flavell, J.B. Bliska and R. Medzhitov. 2010. A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system. Cell. Host. Microbe. 7: 376–387.10.1016/j.chom.2010.04.009288386520478539
]Search in Google Scholar
[
Broz P., J. von Moltke, J.W. Jones, R.E. Vance and D.M. Monack.
2010. Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing. Cell. Host. Microbe. 8: 471–483.10.1016/j.chom.2010.11.007301620021147462
]Search in Google Scholar
[
Cambronne E.D., J.A. Sorg and O. Schneewind. 2004. Binding of SycH chaperone toYscM1 and YscM2 activates effector yop expression in Yersinia enterocolitica. J. Bacteriol. 186: 829–841.10.1128/JB.186.3.829-841.200432149114729710
]Search in Google Scholar
[
Chen Y. and D.M. Anderson. 2011. Expression hierarchy in the Yersinia type III secretion system established through YopD recognition of RNA. Mol. Microbiol. 80(4): 966–980.
]Search in Google Scholar
[
Chung L.K., N.H. Philip, V.A. Schmidt, A. Koller, T. Stowlg, R.A. Flavell, I.E. Brodsky and J.B. Bliska. 2014. IQGAP1 is important for activation of Caspase-1 in macrophages and is targeted by Yersinia pestis type III effector YopM. mBio. 5(4): e01402–14.10.1128/mBio.01402-14416123924987096
]Search in Google Scholar
[
Dessein R., M. Gironella, C. Vignal, L. Peyrin-Biroulet, H. Sokok, T. Secher, S. Lacas-Gervais, J.J. Gratadoux, F. Lafont, J.C. Dagorn and others. 2009. Toll-like receptor 2 is critical for induction of Reg3b expression and intestinal clearance of Yersinia pseudotuberculosis. Gut. 58: 771–776.10.1136/gut.2008.16844319174417
]Search in Google Scholar
[
Dewoody R., P.M. Merritt, A.S. Houppert and M.M. Marketon.
2011. YopK regulates the Yersinia pestis type III secretion system from within host cells. Mol. Microbiol. 79(6): 1445–1461.
]Search in Google Scholar
[
Dewoody R., P.M. Merritt, A.S. Houppert and M.M. Marketon. 2013. Regulation of the Yersinia type III secretion system: traffic control. Front. Cell Infect. Mi. 3(4): 1–13.
]Search in Google Scholar
[
Edqvist P.J., M. Aili, J. Liu and M.S. Francis. 2007. Minimal YopB and YopD translocator secretion by Yersinia is sufficient for Yop-effector delivery into target cells. Microbes Infect. 9: 224–233.10.1016/j.micinf.2006.11.01017223369
]Search in Google Scholar
[
Fallman M., K. Andersson, S. Hakansson, K.E. Magnusson, O. Stendahl and H. Wolf-Watz. 1995. Yersinia pseudotuberculosis inhibits Fc receptor-mediated phagocytosis in J774 cells. Infect. Immun. 63: 3117–3124.10.1128/iai.63.8.3117-3124.19951734257622239
]Search in Google Scholar
[
Galindo C.L., J.A. Rosenzweig, M.L. Kirtley and A.K. Chopra. 2011. Pathogenesis of Yersinia enterocolitica and Yersinia pseudotuberculosisin Human Yersiniosis. J. Pathog. 2011: 1–16.10.4061/2011/182051333567022567322
]Search in Google Scholar
[
Groves E., K. Rittinger, M. Amstutz, S. Berry, D.W. Holden, G.R. Cornelis and E. Caron. 2010. Sequestering of Rac by the Yersinia effector YopO blocks Fcgamma receptor-mediated phagocytosis. J. Biol. Chem. 285: 4087–4098.10.1074/jbc.M109.071035282354919926792
]Search in Google Scholar
[
Hamid N., A. Gustavsson, K. Andersson, K. McGee, C. Persson, C.E. Rudd and M. Fallman. 1999. YopH dephosphorylates Cas and Fyn-binding protein in macrophages. Microb. Pathog. 27: 231–242.10.1006/mpat.1999.030110502464
]Search in Google Scholar
[
Hajjar A.M., R.K. Ernst, E.S.III Fortuno, A.S. Brasfield, C.S. Yam, L.A. Newlon, T.R. Kollmann, S.I. Miller and C.B. Wilson. 2012. Humanized TLR4/MD-2 mice reveal LPS recognition differentially impacts susceptibility to Yersinia pestis and Salmonella enterica. PLoS Pathog. 8(10): e1002963.10.1371/journal.ppat.1002963346966123071439
]Search in Google Scholar
[
Hentschke M., L. Berneking, C.B. Campos, F. Buck, K. Ruckdeschel and M. Aepfelbacher. 2010. Yersinia virulence factor YopM induces sustained RSK activation by interfering with dephosphorylation. PLoS ONE. 5(10): e13165.10.1371/journal.pone.0013165295014420957203
]Search in Google Scholar
[
Holmstrom A., R. Rosqvist, H. Wolf-Watz and A. Forsberg. 1995. Virulence plasmid-encoded YopK is essential for Yersinia pseudotuberculosis to cause systemic infection in mice. Infect. Immun. 63: 2269–2276.10.1128/iai.63.6.2269-2276.19951732967768608
]Search in Google Scholar
[
Jessen D.L., P. Osel-Owusu, M. Toosky, W. Roughead, D.S. Bradley and M.L. Nilles. 2014. Type III secretion needle proteins induce cell signaling and cytokine secretion via toll-like receptors. Infect. Immunity. 82(6): 2300–2309.10.1128/IAI.01705-14401919124643544
]Search in Google Scholar
[
Jorgensen I. and E.A. Miao. 2012. YopM puts Caspase-1 on ice. Cell Host. Microbe. 12(6): 737–738.
]Search in Google Scholar
[
Jung C., U. Meinzer, N. Montcuquet, E. Thachil, D. Chateau, R. Thiebaut, M. Roy, Z. Alnabhani, D. Berrebi, M. Dussaillant and others. 2012. Yersinia pseudotuberculosis disrupts intestinal barrier integrity through hematopoietic TLR-2 signaling. J. Clin. Invest. 122(6): 2239–2251.
]Search in Google Scholar
[
Kerschen E.J., D.A. Cohen, A.M. Kaplan and S.C. Straley. 2004. The plague virulence protein YopM targets the innate immune response by causing a global depletion of NK cells. Infect. Immun. 72(8): 4589–4602.
]Search in Google Scholar
[
LaRock C.N. and B.T. Cookson. 2012. The Yersinia virulence effector YopM binds caspase-1 to arrest inflammasome assembly and processing. Cell Host. Microbe. 12(6): 799–805.
]Search in Google Scholar
[
Luigi F. and N. Gabriel. 2012. Orchestrating Inflammasomes. Science 337: 1299–1230.10.1126/science.1229010434047622984056
]Search in Google Scholar
[
McDonald C., P.O. Vacratsis, J.B. Bliska and J.E. Dixon. 2003. The Yersinia virulence factor YopM forms a novel protein complex with two cellular kinases. J. Biol. Chem. 278(20): 18514–18523.
]Search in Google Scholar
[
Meinzer U., F. Barreau, S. Esmiol-Welterlin, C. Jung, C. Villard, T. Legar, S. Ben-Mkaddem, D. Berrebi, M. Dussaillant, Z. Alnabhani and others. 2012. Yersinia pseudotuberculosis effector YopJ subverts the Nod2/RICK/TAK1 pathway and activates Caspase-1 to induce intestinal barrier dysfunction. Cell Host and Microbe. 11: 337–351.10.1016/j.chom.2012.02.00922520462
]Search in Google Scholar
[
Monack D.M., J. Mecsas, D. Bouley and S. Falkow. 1998. Yersinia-induced apoptosis in vivo aids in the establishment of a systemic infection of mice. J. Exp. Med. 188: 2127–2137.10.1084/jem.188.11.212722123859841926
]Search in Google Scholar
[
Montager C., C. Arquint and G.R. Cornelis. 2011. Translocators YopB and YopD from Yersinia enterocolitica form a multimeric integral membrane complex in eukaryotic cell membranes. J. Bacteriol. 193(24): 6923–69238.
]Search in Google Scholar
[
Mukherjee S., G. Keitany, Y. Li, Y. Wang, H.L. Ball, E.J. Goldsmith and K. Orth. 2006. Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation. Science. 312(5777): 1211–1214.
]Search in Google Scholar
[
Mukherjee S. and K. Orth. 2008. In vitro signaling by MAPK and NFκB pathways inhibited by Yersinia YopJ. Methods. Enzymol. 438: 343–353.10.1016/S0076-6879(07)38024-5
]Search in Google Scholar
[
Navarro L., A. Koller, R. Nordfelth, H. Wolf-Watz, S. Taylor and J.E. Dixon. 2007. Identification of a molecular target for the Yersinia protein kinase A. Mol. Cell. 26: 465–477.10.1016/j.molcel.2007.04.025
]Search in Google Scholar
[
Paquette N., J. Conlon, C. Sweet, F. Rus, L. Wildon, A. Pereira, C.V. Rosadini, N. Goutagny, A.N. Weber, W.S. Lane and others.
2012. Serine/threonine acetylation of TGFβ-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling. Proc. Natl. Acad. Sci. 109(31): 12710–12715.
]Search in Google Scholar
[
Persson C., R. Nordfelth, K. Andersson, A. Forsberg, H. Wolf-Watz and M. Fallman. 1999. Localization of the Yersinia PTPase to focal complexes is an important virulence mechanism. Mol. Microbiol. 33: 828–838.10.1046/j.1365-2958.1999.01529.x
]Search in Google Scholar
[
Philip N.H. and I.E. Brodsky. 2012. Cell death programs in Yersinia immunity and pathogenesis. Front. Cell. Infect. Mi. 2(149): 1–7.
]Search in Google Scholar
[
Philip N.H., C.P. Dillon, A.G. Snyder, P. Fitzgerald, M.A. Wynosky--Dolfi, E.E. Zwack, B. Hu, L. Fitzgerald, E.A. Mauldin, A.M. Copenhaver and others. 2014. Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-κB and MAPK signaling. Proc. Natl. Acad. Sci. 111(20): 7385–7390.10.1073/pnas.1403252111
]Search in Google Scholar
[
Prehna G., M.I. Ivanov, J.B. Bliska and C.E. Stebbins. 2006. Yersinia virulence depends on mimicry of host Rho-family nucleotide dissociation inhibitors. Cell. 26: 869–880.10.1016/j.cell.2006.06.056
]Search in Google Scholar
[
Rimpilainen M., A. Forsberg and H. Wolf-Watz. 1992. Anovel protein, LcrQ, involved in the low-calcium response of Yersinia pseudotuberculosis shows extensive homology to YopH. J. Bacteriol. 174: 3355–3363.
]Search in Google Scholar
[
Ruckdeschel K., A. Deuretzbacher and R. Haase. 2008. Crosstalk of signalling processes of innate immunity with Yersinia Yop effector functions. Immunobiology. 213: 261–269.10.1016/j.imbio.2007.11.001
]Search in Google Scholar
[
Ruckdeschel K., A. Roggenkamp, S. Schubert and J. Heesemann. 1996. Differential contribution of Yersinia enterocolitica virulence factors to evasion of microbicidal action of neutrophils. Infect. Immun. 64: 724–733.10.1128/iai.64.3.724-733.1996
]Search in Google Scholar
[
Ruiz-Bravo A., E. Moreno and M. Jimenez-Valera. 2001. Intestinal infection of BALB/c mice with Yersinia enterocolitica O9 causes major modifications in phenotype and functions of spleen cells. Microbiology. 147: 3165–3169.10.1099/00221287-147-11-3165
]Search in Google Scholar
[
Schmidt G. 2011. Yersinia enterocolitica outer protein T (YopT). Eur. J. Cell. Biol. 90: 955–958.10.1016/j.ejcb.2010.12.005
]Search in Google Scholar
[
Shao F., P.M. Merritt, Z. Bao, R.W. Innes and J.E. Dixon. 2002. A Yersinia effector and a Pseudomonas a virulence protein define a family of cysteine proteases functioning in bacterial pathogenesis. Cell. 109: 575–588.10.1016/S0092-8674(02)00766-3
]Search in Google Scholar
[
Straley S.C. and W.S. Bowmer. 1986. Virulence genes regulated at the transcriptional level by Ca2+ in Yersinia pestis include structural genes for outer membrane proteins. Infect. Immun. 51: 445–454.10.1128/iai.51.2.445-454.1986
]Search in Google Scholar
[
Swietnicki W., B.S. Powell and J. Goodin. 2005. Yersinia pestis Yop secretion protein F: Purification, characterization, and protective efficacy against bubonic plague. Protein. Expres. Purif. 42: 166–172.
]Search in Google Scholar
[
Trcek J., M.F. Oellerich, K. Niedung, F. Ebel, S. Freund and K. Trulzsch. 2011. Gut proteases target Yersinia invasin in vivo. BMC Res. Notes. 4: 129.10.1186/1756-0500-4-129
]Search in Google Scholar
[
Viboud G.I. and J.B. Bliska. 2001. A bacterial type III secretion system inhibits actin polymerization to prevent pore formation in host cell membranes. EMBO J. 20: 5373–5382.10.1093/emboj/20.19.5373
]Search in Google Scholar
[
Viboud G.I. and J.B. Bliska. 2005. Yersinia outer proteins: role in modulation of host cell signaling responses and pathogenesis. Annu. Rev. Microbiol. 59: 69–89.10.1146/annurev.micro.59.030804.121320
]Search in Google Scholar
[
Vladimer G.I., D. Weng, S.W. Montminy Paquette, S.K. Vanaja, V.A.K. Rathinam, M.H. Aune, J.E. Conlon, J.J. Burbage, M.K. Proulx, Q. Liu and others. 2012. The NLRP12 inflammasome recognizes Yersinia pestis. Immunity 37(1): 96–107.10.1016/j.immuni.2012.07.006
]Search in Google Scholar
[
von Moltke J., N.J. Trinidad, M. Moayeri, A.F. Kintzer, S.B. Wang, N. van Rooijen, C.R. Brown, B.A. Krantz, S.H. Leppla, K. Gronert and R.E. Vance. 2012. Rapid induction of inflammatory lipid mediators by the inflammasome in vivo. Nature 490(7418): 107–111.10.1038/nature11351
]Search in Google Scholar
[
Wilharm G., W. Neumayer and J. Heesemann. 2003. Recombinant Yersinia enterocolitica YscM1 andYscM2: homodimer formation and susceptibility to thrombin cleavage. Protein. Expres. Purif. 31: 167–172.10.1016/S1046-5928(03)00183-9
]Search in Google Scholar
[
Zheng T.S., S.F. Schlosser, T. Dao, R. Hingorani, N. Crispe, J.L. Boyer and R.A. Flavell. 1998. Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo. Proc. Natl. Acad. Sci. USA 95: 13618–13623.10.1073/pnas.95.23.13618248689811849
]Search in Google Scholar
[
Zheng Y., S. Lilo, P. Mena and J.B. Bliska. 2012. YopJ-induced cas-pase-1 activation in Yersinia-infected macrophages: independent of apoptosis, linked to necrosis, Dispensable for innate host defense. PLoS ONE. 7(4): e36019.
]Search in Google Scholar
[
Zhou H., D.M. Monack, N. Kayagaki, I. Wertz, J. Yin, B. Wolf and V.M. Dixit. 2005. Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-κB activation. J. Exp. Med. 202(10): 1327–1332.
]Search in Google Scholar
