<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_1905-7415.1005.514_s_001_w2aab3b7c10b1b6b1aab1c17b1Aa"><h3>Background</h3><p>Primary hyperparathyroidism is a common disease in adults, but extremely rare in the pediatric age group. To our knowledge, pediatric primary hyperparathyroidism has never been reported in Thailand.</p></sec><sec id="j_1905-7415.1005.514_s_002_w2aab3b7c10b1b6b1aab1c17b2Aa"><h3>Objectives</h3><p>To describe 3 cases of primary hyperparathyroidism presenting in Thai children with different clinical manifestations.</p></sec><sec id="j_1905-7415.1005.514_s_003_w2aab3b7c10b1b6b1aab1c17b3Aa"><h3>Methods</h3><p>Cases of primary hyperparathyroidism in 3 Thai pediatric patients are reported herein, with a brief literature review.</p></sec><sec id="j_1905-7415.1005.514_s_004_w2aab3b7c10b1b6b1aab1c17b4Aa"><h3>Results</h3><p>Three patients are described. The first patient, a 14-year-old Thai girl, presented with progressively worsening bowlegs and lordosis of the spine for 1.5 years. The second patient, a 15-year-old Thai boy, presented with a history of hip pain and constipation for 3 years. The third patient, an obese 11-year-old Thai boy, presented with acute abdominal pain, which was initially incorrectly diagnosed as acute pancreatitis.</p></sec><sec id="j_1905-7415.1005.514_s_005_w2aab3b7c10b1b6b1aab1c17b5Aa"><h3>Conclusions</h3><p>The clinical symptoms of hyperparathyroidism in Thai children are nonspecific at an early stage of the disease. The diagnoses are usually delayed and the patients therefore suffer complications of long-term hypercalcemia such as bone deformities or renal nephrocalcinosis. We recommend initial laboratory screening in pediatric patients with nonspecific symptoms and complaints of persistent bone pain. Appropriate investigations to confirm or eliminate primary hyperparathyroidism should be made, as an early diagnosis can facilitate early treatment and prevent the organ damage that can result from delayed diagnosis.</p></sec></abstract>

BackgroundPrimary hyperparathyroidism is a common disease in adults, but extremely rare in the pediatric age group. To our knowledge, pediatric primary hyperparathyroidism has never been reported in Thailand.ObjectivesTo describe 3 cases of primary hyperparathyroidism presenting in Thai children with different clinical manifestations.MethodsCases of primary hyperparathyroidism in 3 Thai pediatric patients are reported herein, with a brief literature review.ResultsThree patients are described. The first patient, a 14-year-old Thai girl, presented with progressively worsening bowlegs and lordosis of the spine for 1.5 years. The second patient, a 15-year-old Thai boy, presented with a history of hip pain and constipation for 3 years. The third patient, an obese 11-year-old Thai boy, presented with acute abdominal pain, which was initially incorrectly diagnosed as acute pancreatitis.ConclusionsThe clinical symptoms of hyperparathyroidism in Thai children are nonspecific at an early stage of the disease. The diagnoses are usually delayed and the patients therefore suffer complications of long-term hypercalcemia such as bone deformities or renal nephrocalcinosis. We recommend initial laboratory screening in pediatric patients with nonspecific symptoms and complaints of persistent bone pain. Appropriate investigations to confirm or eliminate primary hyperparathyroidism should be made, as an early diagnosis can facilitate early treatment and prevent the organ damage that can result from delayed diagnosis.

Primary hyperparathyroidism in Thai children: case series and literature review

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Primary hyperparathyroidism in Thai children: case series and literature review"}

BackgroundPrimary hyperparathyroidism is a common disease in adults, but extremely rare in the pediatric age group. To our knowledge, pediatric primary...

	No of patients	Age (years)	Male: female ratio	Adenoma (%)	Bone presentation (%)	Renal complication (%)	PTH level (pg/mL)	Serum calcium level (mmol/L)	Acute pancreatitis (%)	Hungrybone syndrome (%)
Lawson et al. (1996) [3]	11	12–17	0.8	100	75	45	79–930	2.64–4.2	NA	NA
Hannan et al. (1999) [5]	33	9–19	1.1	94	27	42	27–1,700	2.55–4.55	3	NA
Kollars et al. (2005) [1]	52	4–18	0.67	65	34	33	19–1,700	2.5–4.0	7	NA
Venail et al. (2007) [4]	4	7–14	0.33	100	50	50	87–1,580	2.96–4.34	0	50
Libansky et al. (2008) [12]	10	10–17	1	100	30	50	83–547	2.78–3.64	10	NA
Bhadada et al. (2008) [6]	11	5–18	0.57	91	91	50	128–2,085	2.12–3.40	14	77
Mallet et al. (2008) [2]	44	6–18	0.69	66	16	41	56–2,214	2.5–4.33	NA	NA
George et al. (2010) [7]	18	10–18	0.29	100	89	39	80 + 66	3.35 + 0.49	5.5	28
Durkin et al. (2010) [9]	12	10–18	0.09	75	NA	25	77–300	2.73–3.98	0	NA
Li et al. (2012) [8]	12	9–16	0.71	100	92	75	105–2,800	3.25–5	8	NA

Primary hyperparathyroidism in Thai children: case series and literature review

Article Category: Clinical report

Online veröffentlicht: 31. März 2017

Seitenbereich: 503 - 507

DOI: https://doi.org/10.5372/1905-7415.1005.514

Schlüsselwörter
Hypercalcemia, hyperparathyroidism, parathyroid adenoma, parathyroid hyperplasia

© 2016 Piyawut Kreetapirom, Somchit Jaruratanasirikul

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Summary of clinical characteristics of patients with hyperparathyroidism

Primary hyperparathyroidism in Thai children: case series and literature review

Article Category: Clinical report

Online veröffentlicht: 31. März 2017

Seitenbereich: 503 - 507

DOI: https://doi.org/10.5372/1905-7415.1005.514

SchlüsselwörterHypercalcemia, hyperparathyroidism, parathyroid adenoma, parathyroid hyperplasia

© 2016 Piyawut Kreetapirom, Somchit Jaruratanasirikul

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Summary of clinical characteristics of patients with hyperparathyroidism

Schlüsselwörter
Hypercalcemia, hyperparathyroidism, parathyroid adenoma, parathyroid hyperplasia