Human Leukocyte Antigen-G (HLA-G) 14-bp deletion polymorphism is associated with decreased risk of pulmonary fibrosis in Indonesian Javanese patients with multidrug-resistant tuberculosis
Article Category: Brief communication (Original)
Online veröffentlicht: 31. Jan. 2017
Seitenbereich: 473 - 479
DOI: https://doi.org/10.5372/1905-7415.0904.416
Schlüsselwörter
© 2017 Marwoto, Afiono Agung Prasetyo, Ratna Sariyatun, Suradi, Reviono, Harsini
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Distribution of the HLA-G 14-bp in/del polymorphism in the context of MDR-TB patient drug resistance status and the results of the thorax radiographical imaging.
| Genotypes (n,%) | ||||
|---|---|---|---|---|
| D/D(n = 19) | I/D(n = 30) | W(n = 8) | ||
| Drug Resistances some data were missing. | ||||
| Ethambutol | 0.18 | |||
| Sensitive | 12(63) | 14(47) | 4(50) | respectively |
| Resistant | 6(32) | 16(53) | 4(50) | |
| Streptomicin | 0.26 | |||
| Sensitive | 10(53) | 12(40) | 3(38) | respectively |
| Resistant | 8(42) | 18(60) | 5(63) | |
| Rontgen of thorax some data were missing. | ||||
| Cavity | 0.70 | |||
| Negative | 9(47) | 13 (43) | 3(38) | respectively |
| Positive | 9(47) | 16(53) | 4(50) | |
| Infiltration | - | |||
| Negative | 2(11) | 3(10) | 1(13) | |
| Positive | 16(84) | 26(87) | 6(75) | |
| Nodule | - | |||
| Negative | 18(95) | 29(97) | 6(75) | |
| Positive | 0(0) | 0(0) | 1(13) | |
| Fibrosis | 0.02 | |||
| Negative | 14(74) | 23 (77) | 2(25) | |
| Positive | 4(21) | 6(20) | 5(63) | |
| Consolidation | - | |||
| Negative | 17(90) | 29(97) | 7(88) | |
| Positive | 1(5) | 0(0) | 0(0) | |
| Pleural effusion | - | |||
| Negative | 17(90) | 28(93) | 6(75) | |
| Positive | 1(5) | 1(3) | 1(13) | |
Distribution of the HLA-G 14-bp in/del polymorphism in the context of hematologic profiles of MDR-TB patients.
| Genotypes (n,%) | ||||
|---|---|---|---|---|
| D/D(n = 19) | I/D(n = 30) | W(n = 8) | ||
| Hemoglobin (g/dL) some data were missing.γ IFN γ = interferon-gamma; IL-10 = interleukin-10 | - | |||
| <13.3 for men | 9(47) | 16(53) | 4(50) | |
| 13.3-16.75 or 11.8-14.8 for women | 9(47) | 11(37) | 3(38) | |
| >16.7 for men for women | 0(0) | 1(3) | 0(0) | |
| Erythrocytes (×l06/μL) some data were missing.γ IFN γ = interferon-gamma; IL-10 = interleukin-10 | 0.999 | |||
| <4.37 for men for women | 5(26) | 5(17) | 1(13) | 0.56 |
| 4.37-5.66 for men for women | 11(58) | 20(67) | 3(38) | |
| >5.66 for men for women | 2(11) | 3(10) | 3(38) | |
| Leukocytes (×l06μL) some data were missing.γ IFN γ = interferon-gamma; IL-10 = interleukin-10 | 0.45a | |||
| 3.9-11.1 for men for women | 12(63) | 22(73) for women | 4(50) | |
| >11.1 for men for women | 6(32) | 6(20) | 3(38) | |
| Thrombocytes (×105μL) some data were missing.γ IFN γ = interferon-gamma; IL-10 = interleukin-10 | 0.64 | |||
| 1.5-4.0 | 12(63) | 15(50) | 6(75) | 0.23 |
| >4.0 | 6(32) | 13 (43) | 1(13) | |
| Hematocrit (%) some data were missing.γ IFN γ = interferon-gamma; IL-10 = interleukin-10 | 0.999 | |||
| <33 | 4(21) | 5(17) | 2(25) | 0.999 |
| 33-45 | 13 (68) | 19(63) | 5(63) | |
| >45 | 1(5) | 4(13) | 0(0) | |
| Na+ (mEq/L) some data were missing.γ IFN γ = interferon-gamma; IL-10 = interleukin-10 | 0.37 | |||
| <135 | 4(21) | 11(37) | 1(13) | 0.66 for men for women |
| 135-145 | 14(74) | 17(57) | 6(75) | |
| K+(mEq/L) some data were missing.γ IFN γ = interferon-gamma; IL-10 = interleukin-10 | 0.88 | |||
| <3.7 | 5(26) | 7(23) | 1(13) | 0.92 |
| 3.7-5.2 | 6(32) | 12(40) | 2(25) | |
| >5.2 | 7(37) | 9(30) | 4(50) | |
| CD4+ T cell count (cells/μL) | - | |||
| <200 | 1(5) | 0(0) | 0(0) | |
| 200-500 | 3(16) | 7(23) | 4(50) | |
| >500 | 15(79) | 23 (77) | 4(50) | |
| %CD4+Tcells | 0.96 | |||
| 14-28 | 6(32) | 10(33) | 3(38) | |
| >29 | 13 (68) | 20(67) | 5(63) | |
| IFNa(pg/mL) | 0.34 | |||
| <10 | 13 for women | 19(63) | 2(25) | 0.05 for men for women |
| >10 | 6(32) | 11(37) | 6(75) | |
| IL-10(pg/mL) | ||||
| <10 | 18(95) | 30(100) | 8(100) | - |
| >10 | 1(5) | 0(0) | 0(0) | |