[1. Chen L, Magliano DJ, Zimmet PZ. The worldwide epidemiology of type 2 diabetes mellitus-present and future perspectives. Nat Rev Endocrinol. 2012; 8: 228-36.10.1038/nrendo.2011.183]Open DOISearch in Google Scholar
[2. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001; 414:813-20.10.1038/414813a]Search in Google Scholar
[3. Giacco F, Brownlee M. Oxidative stress and diabetic complications. Circ Res. 2010; 107:1058-70.10.1161/CIRCRESAHA.110.223545]Search in Google Scholar
[4. Rask-Madsen C, King GL. Vascular complications of diabetes: mechanisms of injury and protective factors. Cell Metab. 2013; 17:20-33.10.1016/j.cmet.2012.11.012]Search in Google Scholar
[5. van den Oever IA, Raterman HG, Nurmohamed MT, Simsek S. Endothelial dysfunction, inflammation, and apoptosis in diabetes mellitus. Mediators Inflamm. 2010; 2010:792393.10.1155/2010/792393]Search in Google Scholar
[6. Schafer A, Bauersachs J. Endothelial dysfunction, impaired endogenous platelet inhibition and platelet activation in diabetes and atherosclerosis. Curr Vasc Pharmacol. 2008; 6:52-60.10.2174/157016108783331295]Open DOISearch in Google Scholar
[7. Robson SC, S⃞vigny J, Zimmermann H. The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance. Purinergic Signal. 2006; 2:409-30.10.1007/s11302-006-9003-5]Open DOISearch in Google Scholar
[8. Wang TF, Guidotti G. CD39 is an ecto-(Ca2+,Mg2+)- apyrase. J Biol Chem. 1996; 271:9898-901.10.1074/jbc.271.17.9898]Search in Google Scholar
[9. Wang TF, Guidotti G. Widespread expression of ectoapyrase (CD39) in the central nervous system. Brain Res. 1998; 790:318-22.10.1016/S0006-8993(97)01562-X]Search in Google Scholar
[10. Dwyer KM, Deaglio S, Gao W, Friedman D, Strom TB, Robson SC. CD39 and control of cellular immune responses. Purinergic Signal. 2007; 3:171-80.10.1007/s11302-006-9050-y209676618404431]Open DOISearch in Google Scholar
[11. Atkinson B, Dwyer K, Enjyoji K, Robson SC. Ectonucleotidases of the CD39/NTPDase family modulate platelet activation and thrombus formation: Potential as therapeutic targets. Blood Cells Mol Dis. 2006; 36: 217-22.10.1016/j.bcmd.2005.12.025]Search in Google Scholar
[12. Marcus AJ, Broekman MJ, Drosopoulos JH, Islam N, Alyonycheva TN, Safier LB, et al. The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39. J Clin Invest. 1997; 99:1351-60.10.1172/JCI119294]Search in Google Scholar
[13. Koziak K, Sevigny J, Robson SC, Siegel JB, Kaczmarek E. Analysis of CD39/ATP diphosphohydrolase (ATPDase) expression in endothelial cells, platelets and leukocytes. Thromb Haemost. 1999; 82:1538-44.10.1055/s-0037-1614868]Search in Google Scholar
[14. Michno A, Bielarczyk H, Pawelczyk T, Jankowska- Kulawy A, Klimaszewska J, Szutowicz A. Alterations of adenine nucleotide metabolism and function of blood platelets in patients with diabetes. Diabetes. 2007; 56:462-7.10.2337/db06-0390]Search in Google Scholar
[15. Sobol AB, Watala C. The role of platelets in diabetesrelated vascular complications. Diabetes Res Clin Pract. 2000; 50:1-16.10.1016/S0168-8227(00)00160-1]Open DOISearch in Google Scholar
[16. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983; 65: 55-63.10.1016/0022-1759(83)90303-4]Search in Google Scholar
[17. Oez S, Platzer E, Welte K. A quantitative colorimetric method to evaluate the functional state of human polymorphonuclear leukocytes. Blut. 1990; 60:97-102.10.1007/BF017205152302467]Search in Google Scholar
[18. Ido Y, Carling D, Ruderman N. Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation. Diabetes. 2002; 51:159-67.10.2337/diabetes.51.1.15911756336]Open DOISearch in Google Scholar
[19. Leal EC, Aveleira CA, Castilho AF, Serra AM, Baptista FI, Hosoya K, et al. High glucose and oxidative/nitrosative stress conditions induce apoptosis in retinal endothelial cells by a caspaseindependent pathway. Exp Eye Res. 2009; 88:983-91.10.1016/j.exer.2008.12.01019146853]Search in Google Scholar
[20. Altannavch TS, Roubalova K, Kucera P, Andel M. Effect of high glucose concentrations on expression of ELAM-1, VCAM-1 and ICAM-1 in HUVEC with and without cytokine activation. Physiol Res. 2004; 53:77-82.10.33549/physiolres.930343]Search in Google Scholar
[21. Yang Z, Laubach VE, French BA, Kron IL. Acute hyperglycemia enhances oxidative stress and exacerbates myocardial infarction by activating nicotinamide adenine dinucleotide phosphate oxidase during reperfusion. J Thorac Cardiovasc Surg. 2009; 137:723-9.10.1016/j.jtcvs.2008.08.056268002719258097]Search in Google Scholar
[22. Yano M, Hasegawa G, Ishii M, Yamasaki M, Fukui M, Nakamura N, et al. Short-term exposure of high glucose concentration induces generation of reactive oxygen species in endothelial cells: implication for the oxidative stress associated with postprandial hyperglycemia. Redox Rep. 2004; 9:111-6.10.1179/13510000422500477915231066]Open DOISearch in Google Scholar
[23. Monnier L, Mas E, Ginet C, Michel F, Villon L, Cristol JP, et al. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA. 2006 ; 295:1681-7.10.1001/jama.295.14.168116609090]Search in Google Scholar
[24. Favaloro EJ. Differential expression of surface antigens on activated endothelium. Immunol Cell Biol. 1993; 71:571-81.10.1038/icb.1993.638314284]Search in Google Scholar
[25. Kapojos JJ, van den Berg A, Borghuis T, Banas B, Huitema S, Poelstra K, et al. Enhanced ecto-apyrase activity of stimulated endothelial or mesangial cells is downregulated by glucocorticoids in vitro. Eur J Pharmacol. 2004; 501:191-8.10.1016/j.ejphar.2004.08.00815464078]Search in Google Scholar
[26. Wurm A, Iandiev I, Hollborn M, Wiedemann P, Reichenbach A, Zimmermann H, et al. Purinergic receptor activation inhibits osmotic glial cell swelling in the diabetic rat retina. Exp Eye Res. 2008; 87:385-93.10.1016/j.exer.2008.07.00418687327]Search in Google Scholar
[27. Lunkes GI, Lunkes DS, Leal D, Araujo Mdo C, Correa M, Becker L, et al. Effect of high glucose levels in human platelet NTPDase and 5?-nucleotidase activities. Diabetes Res Clin Pract. 2008; 81:351-7.10.1016/j.diabres.2008.06.00118644642]Search in Google Scholar
[28. Garcia-Hernandez MH, Portales-Cervantes L, Cortez- Espinosa N, Vargas-Morales JM, Fritche Salazar JF, Rivera-Lopez E, et al. Expression and function of P2X(7) receptor and CD39/Entpd1 in patients with type 2 diabetes and their association with biochemical parameters. Cell Immunol. 2011; 269:135-43. 10.1016/j.cellimm.2011.03.02221492831]Search in Google Scholar