[1. Shimizu T, Ohshima I, Ozawa M, Takahashi S, Tajima A, Shiota M, et al. Heat stress diminishes gonadotropin receptor expression and enhances susceptibility to apoptosis of rat granulosa cells. Reproduction. 2005; 129:463-72.10.1530/rep.1.00502]Search in Google Scholar
[2. Hsu YL, Yu HS, Lin HC, Wu KY, Yang RC, Kuo PL. Heat shock induces apoptosis through reactive oxygen species involving mitochondrial and death receptor pathways in corneal cells. Exp Eye Res. 2011; 93:405-12.10.1016/j.exer.2011.06.005]Search in Google Scholar
[3. Nijhuis EH, Le Gac S, Poot AA, Feijen J, Vermes I. Bax-mediated mitochondrial membrane permeabilization after heat treatment is caspase-2 dependent. Int J Hyperthermia. 2008; 24:357-65.10.1080/02656730801944914]Open DOISearch in Google Scholar
[4. Meldrum KK, Meldrum DR, Sezen SF, Crone JK, Burnett AL. Heat shock prevents simulated ischemiainduced apoptosis in renal tubular cells via a PKCdependent mechanism. Am J Physiol Regul Integr Comp Physiol. 2001; 281:R359-64.10.1152/ajpregu.2001.281.1.R359]Search in Google Scholar
[5. Marfe G, Pucci B, De Martino L, Fiorito F, Di Stefano C, Indelicato M, et al. Heat-shock pretreatment inhibits sorbitol-induced apoptosis in K562, U937 and HeLa cells. Int J Cancer. 2009; 125:2077-85.10.1002/ijc.24572]Search in Google Scholar
[6. Chen HW, Hsu C, Lue SI, Yang RC. Attenuation of sepsis-induced apoptosis by heat shock pretreatment in rats. Cell Stress Chaperones. 2000; 5:188-95.10.1379/1466-1268(2000)005<0188:AOSIAB>2.0.CO;2]Open DOISearch in Google Scholar
[7. Subjeck JR, Sciandra JJ, Johnson RJ. Heat shock proteins and thermotolerance; a comparison of induction kinetics. Br J Radiol. 1982; 55:579-84.10.1259/0007-1285-55-656-579]Search in Google Scholar
[8. Liang P, Jiang B, Huang X, Xiao W, Zhang P, Yang X, et al. Anti-apoptotic role of EGF in HaCaT keratinocytes via a PPAR β-dependent mechanism. Wound Repair Regen. 2008; 16:691-8.10.1111/j.1524-475X.2008.00419.x]Open DOISearch in Google Scholar
[9. Jiang B, Liang P, Zhang B, Song J, Huang X, Xiao X. Role of PPAR-β in hydrogen peroxide-induced apoptosis in human umbilical vein endothelial cells. Atherosclerosis. 2009; 204:353-8.10.1016/j.atherosclerosis.2008.09.009]Search in Google Scholar
[10. Jiang B, Liang P, Zhang B, Huang X, Xiao X. Enhancement of PPAR-β activity by repetitive lowgrade H2O2 stress protects human umbilical vein endothelial cells from subsequent oxidative stressinduced apoptosis. Free Radic Biol Med. 2009; 46: 555-63.10.1016/j.freeradbiomed.2008.10.051]Search in Google Scholar
[11. Sholley MM, Gudas SA, Schwartz CC, Kalimi MY. Dehydroepiandrosterone and related steroids induce multilamellar lipid structures in cultured human endothelial cells. Am J Pathol. 1990; 136:1187-99.]Search in Google Scholar
[12. Sznaidman ML, Haffner CD, Maloney PR, Fivush A, Chao E, Goreham D, et al. Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)-synthesis and biological activity. Bioorg Med Chem Lett. 2003; 13:1517-21.10.1016/S0960-894X(03)00207-5]Open DOISearch in Google Scholar
[13. Fan Y, Wang Y, Tang Z, Zhang H, Qin X, Zhu Y, et al. Suppression of pro-inflammatory adhesion molecules by PPAR-delta in human vascular endothelial cells. Arterioscler Thromb Vasc Biol. 2008; 28:315-21.10.1161/ATVBAHA.107.14981518048767]Open DOISearch in Google Scholar
[14. Itoh YH, Aihara M, Oguri T, Miyata N. [Thermotolerance and heat shock protein (HSP 70) in vascular endothelial cells]. Nihon Igaku Hoshasen Gakkai Zasshi. 1994; 54: 1187-9. (In Japanese, English abstract)]Search in Google Scholar
[15. Haimovitz-Friedman A, Cordon-Cardo C, Bayoumy S, Garzotto M, McLoughlin M, Gallily R, et al. Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation. J Exp Med. 1997; 186:1831-41.10.1084/jem.186.11.183121991519382882]Search in Google Scholar
[16. Aoki M, Nata T, Morishita R, Matsushita H, Nakagami H, Yamamoto K, et al. Endothelial apoptosis induced by oxidative stress through activation of NF-êB: antiapoptotic effect of antioxidant agents on endothelial cells. Hypertension. 2001; 38:48-55.10.1161/01.HYP.38.1.48]Open DOISearch in Google Scholar
[17. Michalik L, Desvergne B, Tan NS, Basu-Modak S, Escher P, Rieusset J, et al. Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)_ and PPAR-â mutant mice. J Cell Biol. 2001; 154:799-814.10.1083/jcb.200011148219645511514592]Search in Google Scholar
[18. Tzika AA, Mintzopoulos D, Mindrinos M, Zhang J, Rahme LG, Tompkins RG. Microarray analysis suggests that burn injury results in mitochondrial dysfunction in human skeletal muscle. Int J Mol Med. 2009; 24: 387-92.10.3892/ijmm_00000244320725119639232]Open DOISearch in Google Scholar
[19. Takasu T, Lyons JC, Park HJ, Song CW. Apoptosis and perturbation of cell cycle progression in an acidic environment after hyperthermia. Cancer Res. 1998; 58: 2504-8.]Search in Google Scholar
[20. Deng H, Ravikumar TS, Yang WL. Bone morphogenetic protein-4 inhibits heat-induced apoptosis by modulating MAPK pathways in human colon cancer HCT116 cells. Cancer Lett. 2007; 256:207-17.10.1016/j.canlet.2007.06.00817640799]Search in Google Scholar
[21. Martindale JL, Holbrook NJ. Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol. 2002; 192:1-15.10.1002/jcp.1011912115731]Search in Google Scholar
[22. Quigney DJ, Gorman AM, Samali A. Heat shock protects PC12 cells against MPP+ toxicity. Brain Res. 2003; 993:133-9.10.1016/j.brainres.2003.09.00414642838]Search in Google Scholar
[23. Gorman AM, Szegezdi E, Quigney DJ, Samali A. Hsp27 inhibits 6-hydroxydopamine-induced cytochrome crelease and apoptosis in PC12 cells. Biochem Biophys Res Commun. 2005; 327:801-10.10.1016/j.bbrc.2004.12.06615649417]Search in Google Scholar
[24. Zeise E, Rensing L. Hyperthermic pre-treatment protects rat IPC-81 leukaemia cells against heat- and hydrogen peroxide-induced apoptosis. Int J Hyperthermia. 2002; 18:344-60.10.1080/02656730210123561]Open DOISearch in Google Scholar
[25. A unified nomenclature system for the nuclear receptor superfamily. Cell. 1999; 97:161-3.10.1016/S0092-8674(00)80726-6]Search in Google Scholar
[26. Akiyama TE, Sakai S, Lambert G, Nicol CJ, Matsusue K, Pimprale S, et al. Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux. Mol Cell Biol. 2002; 22:2607-19.10.1128/MCB.22.8.2607-2619.200213370911909955]Open DOISearch in Google Scholar
[27. Clark RB. The role of PPARs in inflammation and immunity. J Leukoc Biol. 2002; 71:388-400.10.1189/jlb.71.3.388]Search in Google Scholar
[28. Kim DJ, Bility MT, Billin AN, Willson TM, Gonzalez FJ, Peters JM. PPAR β /☐ selectively induces differentiation and inhibits cell proliferation. Cell Death Differ. 2006; 13:53-60.10.1038/sj.cdd.440171316021179]Open DOISearch in Google Scholar
[29. Kim HJ, Kim MY, Hwang JS, Kim HJ, Lee JH, Chang KC, et al. PPAR_β inhibits IL-1 β-stimulated proliferation and migration of vascular smooth muscle cells via up-regulation of IL-1Ra. Cell Mol Life Sci. 2010; 67: 2119-30.10.1007/s00018-010-0328-420221783]Search in Google Scholar
[30. Muller R, Rieck M, Muller-Brusselbach S. Regulation of cell proliferation and differentiation by PPAR- β/☐. PPAR Res. 2008; 2008:614852.10.1155/2008/614852254284318815620]Search in Google Scholar
[31. Tsuji K, Mitsutake S, Yokose U, Sugiura M, Kohama T, Igarashi Y. Role of ceramide kinase in peroxisome proliferator-activated receptor β -induced cell survival of mouse keratinocytes. FEBS J. 2008; 275:3815-26.10.1111/j.1742-4658.2008.06527.x18565104]Search in Google Scholar
[32. Kim HJ, Kim MY, Jin H, Kim HJ, Kang SS, Kim HJ, et al. Peroxisome proliferator-activated receptor egulates extracellular matrix and apoptosis of vascular smooth muscle cells through the activation of transforming growth factor-_1/Smad3. Circ Res. 2009; 105:16-24.10.1161/CIRCRESAHA.108.18915919461048]Search in Google Scholar
[33. Tan NS, Michalik L, Noy N, Yasmin R, Pacot C, Heim M, et al. Critical roles of PPAR β /☐ in keratinocyte response to inflammation. Genes Dev. 2001; 15: 3263-77.10.1101/gad.20750131285511751632]Open DOISearch in Google Scholar
[34. Tan NS, Michalik L, Desvergne B, Wahli W. Geneticor transforming growth factor-beta 1-induced changes in epidermal peroxisome proliferator-activated receptor beta/delta expression dictate wound repair kinetics. J Biol Chem. 2005; 280:18163-70.10.1074/jbc.M41282920015708854]Search in Google Scholar
[35. Tugwood JD, Issemann I, Anderson RG, Bundell KR, McPheat WL, Green S. The mouse peroxisome proliferator activated receptor recognizes a response element in the 5' flanking sequence of the rat acyl CoA oxidase gene. EMBO J. 1992; 11:433-9.10.1002/j.1460-2075.1992.tb05072.x]Search in Google Scholar
[36. Lemay DG, Hwang DH. Genome-wide identification of peroxisome proliferator response elements using integrated computational genomics. J Lipid Res. 2006; 47:1583-7.10.1194/jlr.M500504-JLR20016585784]Open DOISearch in Google Scholar
[37. Adhikary T, Kaddatz K, Finkernagel F, Schönbauer A, Meissner W, Scharfe M, et al. Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor- β /☐ (PPAR β /☐). PLoS One. 2011; 6:e16344.10.1371/journal.pone.0016344302380421283829]Open DOISearch in Google Scholar
[38. Di Paola R, Crisafulli C, Mazzon E, Esposito E, Paterniti I, Galuppo M, et al. GW0742, a high-affinity PPAR- β /☐ agonist, inhibits acute lung injury in mice. Shock. 2010; 33:426-35.10.1097/SHK.0b013e3181b8f2fb20407409]Open DOISearch in Google Scholar
[39. Di Paola R, Esposito E, Mazzon E, Paterniti I, Galuppo M, Cuzzocrea S. GW0742, a selective PPAR β /☐ agonist, contributes to the resolution of inflammation after gut ischemia/reperfusion injury. J Leukoc Biol. 2010; 88:291-301.10.1189/jlb.011005320430778]Search in Google Scholar
[40. Yin KJ, Deng Z, Hamblin M, Xiang Y, Huang H, Zhang J, et al. Peroxisome proliferator-activated receptor ⃞ regulation of miR-15a in ischemia-induced cerebral vascular endothelial injury. J Neurosci. 2010; 30:6398-408.10.1523/JNEUROSCI.0780-10.2010287474420445066]Open DOISearch in Google Scholar