[1. Michaud CM, McKenna MT, Begg S, Tomijima N, Majmudar M, Bulzacchelli MT, et al. The burden of disease and injury in the United States 1996. Popul Health Metr. 2006; 4:11.10.1186/1478-7954-4-11163573617049081]Search in Google Scholar
[2. Spector TD, MacGregor AJ. Risk factors for osteoarthritis: genetics. Osteoarthritis Cartilage. 2004; 12:S39-44.10.1016/j.joca.2003.09.00514698640]Open DOISearch in Google Scholar
[3. Valdes AM, Spector TD. The contribution of genes to osteoarthritis. Med Clin North Am. 2009 ; 93:45-66.10.1016/j.mcna.2008.08.00719059021]Open DOISearch in Google Scholar
[4. Lee YH, Rho YH, Choi SJ, Ji JD, Song GG. Osteoarthritis susceptibility loci defined by genome scan metaanalysis. Rheumatol Int. 2006; 26:996-1000.10.1007/s00296-006-0120-916583188]Open DOISearch in Google Scholar
[5. Valdes AM, Van Oene M, Hart DJ, Surdulescu GL, Loughlin J, Doherty M, et al. Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women. Arthritis Rheum. 2006; 54:533-9.10.1002/art.2162116453284]Open DOISearch in Google Scholar
[6. Benito MJ, Veale DJ, FitzGerald O, van den Berg WB, Bresnihan B. Synovial tissue inflammation in early and late osteoarthritis. Ann Rheum Dis. 2005; 64:1263-7.10.1136/ard.2004.025270175562915731292]Open DOISearch in Google Scholar
[7. Leppavuori J, Kujala U, Kinnunen J, Kaprio J, Nissila M, Heliovaara M, et al. Genome scan for predisposing loci for distal interphalangeal joint osteoarthritis: evidence for a locus on 2q. Am J Hum Genet. 1999; 65: 1060-7.10.1086/302569128823910486325]Open DOISearch in Google Scholar
[8. Tseng S, Reddi AH, Di Cesare PE. Cartilage Oligomeric Matrix Protein (COMP): A Biomarker of Arthritis. Biomark Insights. 2009; 4:33-44.10.4137/BMI.S645]Search in Google Scholar
[9. Mabuchi A, Ikeda T, Fukuda A, Koshizuka Y, Hiraoka H, Miyoshi K, et al. Identification of sequence polymorphisms of the COMP (cartilage oligomeric matrix protein) gene and association study in osteoarthrosis of the knee and hip joints. J Hum Genet. 2001; 46:456-62.10.1007/s10038017004511501943]Open DOISearch in Google Scholar
[10. Valdes AM, Loughlin J, Oene MV, Chapman K, Surdulescu GL, Doherty M, et al. Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee. Arthritis Rheum. 2007;56: 137-46.10.1002/art.2230117195216]Search in Google Scholar
[11. Nelson F, Dahlberg L, Laverty S, Reiner A, Pidoux I, Ionescu M, et al. Evidence for altered synthesis of type II collagen in patients with osteoarthritis. J Clin Invest. 1998; 102:2115-25.10.1172/JCI4853]Open DOISearch in Google Scholar
[12. Baldwin CT, Cupples LA, Joost O, Demissie S, Chaisson C, McAlindon T, et al. Absence of linkage or association for osteoarthritis with the vitamin D receptor/type II collagen locus: the Framingham Osteoarthritis Study. J Rheumatol. 2002; 29:161-5.]Search in Google Scholar
[13. Jakkula E, Melkoniemi M, Kiviranta I, Lohiniva J, Raina SS, Perala M, et al. The role of sequence variations within the genes encoding collagen II, IX and XI in non-syndromic, early-onset osteoarthritis. Osteoarthritis Cartilage. 2005; 13:497-507.10.1016/j.joca.2005.02.005]Open DOISearch in Google Scholar
[14. Kizawa H, Kou I, Iida A, Sudo A, Miyamoto Y, Fukuda A, et al. An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis. Nat Genet. 2005; 37: 138-44.10.1038/ng1496]Open DOISearch in Google Scholar
[15. Mototani H, Mabuchi A, Saito S, Fujioka M, Iida A, Takatori Y, et al. A functional single nucleotide polymorphism in the core promoter region of CALM1 is associated with hip osteoarthritis in Japanese. Hum Mol Genet. 2005; 14:1009-17.10.1093/hmg/ddi093]Open DOISearch in Google Scholar
[16. Corr M. Wnt-beta-catenin signaling in the pathogenesis of osteoarthritis. Nat Clin Pract Rheumatol. 2008; 4: 550-6.10.1038/ncprheum0904]Open DOISearch in Google Scholar
[17. Kim SJ, Im DS, Kim SH, Ryu JH, Hwang SG, Seong JK, et al. Beta-catenin regulates expression of cyclooxygenase-2 in articular chondrocytes. Biochem Biophys Res Commun. 2002; 296:221-6.10.1016/S0006-291X(02)00824-0]Open DOISearch in Google Scholar
[18. Diarra D, Stolina M, Polzer K, Zwerina J, Ominsky MS, Dwyer D, et al. Dickkopf-1 is a master regulator of joint remodeling. Nat Med. 2007; 13:156-63.10.1038/nm153817237793]Open DOISearch in Google Scholar
[19. Loughlin J, Dowling B, Chapman K, Marcelline L, Mustafa Z, Southam L, et al. Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. Proc Natl Acad Sci U S A. 2004; 101:9757-62.10.1073/pnas.040345610147074715210948]Open DOISearch in Google Scholar
[20. Urano T, Narusawa K, Shiraki M, Usui T, Sasaki N, Hosoi T, et al. Association of a single nucleotide polymorphism in the WISP1 gene with spinal osteoarthritis in postmenopausal Japanese women. J Bone Miner Metab. 2007; 25:253-8.10.1007/s00774-007-0757-917593496]Open DOISearch in Google Scholar
[21. Bergink AP, van Meurs JB, Loughlin J, Arp PP, Fang Y, Hofman A, et al. Estrogen receptor alpha gene haplotype is associated with radiographic osteoarthritis of the knee in elderly men and women. Arthritis Rheum. 2003; 48:1913-22.10.1002/art.1104612847685]Open DOISearch in Google Scholar
[22. Jin SY, Hong SJ, Yang HI, Park SD, Yoo MC, Lee HJ, et al. Estrogen receptor-alpha gene haplotype is associated with primary knee osteoarthritis in Korean population. Arthritis Res Ther. 2004; 6:R415-21.10.1186/ar1207]Open DOISearch in Google Scholar
[23. Jordan KM, Syddall H, Dennison EM, Cooper C, Arden NK. Birthweight, vitamin D receptor gene polymorphism, and risk of lumbar spine osteoarthritis. J Rheumatol. 2005; 32:678-83.]Search in Google Scholar
[24. Lian K, Lui L, Zmuda JM, Nevitt MC, Hochberg MC, Lee JM, et al. Estrogen receptor alpha genotype is associated with a reduced prevalence of radiographic hip osteoarthritis in elderly Caucasian women. Osteoarthritis Cartilage. 2007; 15:972-8.10.1016/j.joca.2007.02.020]Open DOISearch in Google Scholar
[25. Uitterlinden AG, Burger H, van Duijn CM, Huang Q, Hofman A, Birkenhager JC, et al. Adjacent genes, for COL2A1 and the vitamin D receptor, are associated with separate features of radiographic osteoarthritis of the knee. Arthritis Rheum. 2000; 43:1456-64.10.1002/1529-0131(200007)43:7<1456::AID-ANR7>3.0.CO;2-M]Open DOISearch in Google Scholar
[26. Valdes AM, Hart DJ, Jones KA, Surdulescu G, Swarbrick P, Doyle DV, et al. Association study of candidate genes for the prevalence and progression of knee osteoarthritis. Arthritis Rheum. 2004; 50: 2497-507.10.1002/art.20443]Open DOISearch in Google Scholar
[27. Bid HK, Mishra DK, Mittal RD. Vitamin-D receptor (VDR) gene (Fok-I, Taq-I and Apa-I) polymorphisms in healthy individuals from north Indian population. Asian Pac J Cancer Prev. 2005; 6:147-52.]Search in Google Scholar
[28. Huang J, Ushiyama T, Inoue K, Kawasaki T, Hukuda S. Vitamin D receptor gene polymorphisms and osteoarthritis of the hand, hip, and knee: acase-control study in Japan. Rheumatology (Oxford). 2000; 39: 79-84.10.1093/rheumatology/39.1.79]Open DOISearch in Google Scholar
[29. Lee YH, Woo JH, Choi SJ, Ji JD, Song GG. Vitamin D receptor TaqI, BsmI and ApaI polymorphisms and osteoarthritis susceptibility: A meta-analysis. Joint Bone Spine. 2009 ; 76:156-61.10.1016/j.jbspin.2008.06.011]Open DOISearch in Google Scholar
[30. Wilkins JM, Southam L, Mustafa Z, Chapman K, Loughlin J. Association of a functional microsatellite within intron 1 of the BMP5 gene with susceptibility to osteoarthritis. BMC Med Genet. 2009; 10:141.10.1186/1471-2350-10-141]Search in Google Scholar
[31. Miyamoto Y, Mabuchi A, Shi D, Kubo T, Takatori Y, Saito S, et al. A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis. Nat Genet. 2007; 39:529-33.10.1038/2005]Search in Google Scholar
[32. Southam L, Rodriguez-Lopez J, Wilkins JM, Pombo- Suarez M, Snelling S, Gomez-Reino JJ, et al. An SNP in the 5'-UTR of GDF5 is associated with osteoarthritis susceptibility in Europeans and with in vivo differences in allelic expression in articular cartilage. Hum Mol Genet. 2007; 16:2226-32.10.1093/hmg/ddm174]Search in Google Scholar
[33. Honsawek S, Chayanupatkul M, Tanavalee A, Sakdinakiattikoon M, Deepaisarnsakul B, Yuktanandana P, et al. Relationship of plasma and synovial fluid BMP-7 with disease severity in knee osteoarthritis patients: a pilot study. Int Orthop. 2009; 33:1171-5.10.1007/s00264-009-0751-z]Open DOISearch in Google Scholar
[34. Hayashi M, Muneta T, Ju YJ, Mochizuki T, Sekiya I. Weekly intra-articular injections of bone morphogenetic protein-7 inhibits osteoarthritis progression. Arthritis Res Ther. 2008; 10:R118.10.1186/ar2521259280518826579]Search in Google Scholar
[35. Meulenbelt I, Min JL, Bos S, Riyazi N, Houwing- Duistermaat JJ, van der Wijk HJ, et al. Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis. Hum Mol Genet. 2008; 17:1867-75.10.1093/hmg/ddn08218334578]Open DOISearch in Google Scholar
[36. Kerna I, Kisand K, Tamm AE, Lintrop M, Veske K, Tamm AO. Missense single nucleotide polymorphism of the ADAM12 gene is associated with radiographic knee osteoarthritis in middle-aged Estonian cohort. Osteoarthritis Cartilage. 2009; 17:1093-8.10.1016/j.joca.2009.02.00619268722]Open DOISearch in Google Scholar
[37. Rodriguez-Lopez J, Pombo-Suarez M, Loughlin J, Tsezou A, Blanco FJ, Meulenbelt I, et al. Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes. Osteoarthritis Cartilage. 2009; 17:321-7.10.1016/j.joca.2008.07.01218790654]Open DOISearch in Google Scholar
[38. Barlas IO, Sezgin M, Erdal ME, Sahin G, Ankarali HC, Altintas ZM, et al. Association of (-1,607) 1G/2G polymorphism of matrix metalloproteinase-1 gene with knee osteoarthritis in the Turkish population (knee osteoarthritis and MMPs gene polymorphisms). Rheumatol Int. 2009; 29:383-8.10.1007/s00296-008-0705-618802702]Search in Google Scholar
[39. Lories RJ, Peeters J, Bakker A, Tylzanowski P, Derese I, Schrooten J, et al. Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice. Arthritis Rheum. 2007; 56:4095-103.10.1002/art.2313718050203]Open DOISearch in Google Scholar
[40. Roach HI, Aigner T. DNA methylation in osteoarthritic chondrocytes: a new molecular target. Osteoarthritis Cartilage. 2007; 15:128-37.10.1016/j.joca.2006.07.00216908204]Open DOISearch in Google Scholar
[41. Iliopoulos D, Malizos KN, Tsezou A. Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention. Ann Rheum Dis. 2007; 66:1616-21.10.1136/ard.2007.069377209532117502362]Open DOISearch in Google Scholar
[42. Iliopoulos D, Malizos KN, Oikonomou P, Tsezou A. Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks. PLoS ONE. 2008; 3:e3740.10.1371/journal.pone.0003740258294519011694]Open DOISearch in Google Scholar
[43. Loughlin J, Sinsheimer JS, Carr A, Chapman K. The CALM1 core promoter polymorphism is not associated with hip osteoarthritis in a United Kingdom Caucasian population. Osteoarthritis Cartilage. 2006; 14:295-8.10.1016/j.joca.2005.11.00116359877]Open DOISearch in Google Scholar
[44. Shi D, Ni H, Dai J, Qin J, Xu Y, Zhu L, et al. Lack of association between the CALM1 core promoter polymorphism (-16C/T) and susceptibility to knee osteoarthritis in a Chinese Han population. BMC Med Genet. 2008; 9:91.10.1186/1471-2350-9-91257605618940010]Open DOISearch in Google Scholar
[45. Tsezou A, Satra M, Oikonomou P, Bargiotas K, Malizos KN. The growth differentiation factor 5 (GDF5) core promoter polymorphism is not associated with knee osteoarthritis in the Greek population. J Orthop Res. 2008; 26:136-40.10.1002/jor.2046417676627]Search in Google Scholar
[46. Kochi Y, Suzuki A, Yamada R, Yamamoto K. Genetics of rheumatoid arthritis: underlying evidence of ethnic differences. J Autoimmun. 2009; 32:158-62.10.1016/j.jaut.2009.02.02019324521]Open DOISearch in Google Scholar
[47. Glasson SS, Askew R, Sheppard B, Carito B, Blanchet T, Ma HL, et al. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature. 2005; 434:644-8.10.1038/nature0336915800624]Search in Google Scholar
[48. Ikegawa S. New gene associations in osteoarthritis: what do they provide, and where are we going? Curr Opin Rheumatol. 2007; 19:429-34.10.1097/BOR.0b013e32825b079d17762607]Open DOISearch in Google Scholar
[49. Honsawek S, Tanavalee A, Sakdinakiattikoon M, Chayanupatkul M, Yuktanandana P. Correlation of plasma and synovial fluid osteopontin with disease severity in knee osteoarthritis. Clin Biochem. 2009; 42: 808-12.10.1016/j.clinbiochem.2009.02.00219217889]Open DOISearch in Google Scholar
[50. Honsawek S, Tanavalee A, Yuktanandana P. Elevated circulating and synovial fluid endoglin are associated with primary knee osteoarthritis severity. Arch Med Res. 2009; 40:590-4.10.1016/j.arcmed.2009.07.01020082874]Open DOISearch in Google Scholar
[51. Li WW, Nemirovskiy O, Fountain S, Rodney Mathews W, Szekely-Klepser G. Clinical validation of an immunoaffinity LC-MS/MS assay for the quantification of a collagen type II neoepitope peptide: A biomarker of matrix metalloproteinase activity and osteoarthritis in human urine. Anal Biochem. 2007; 369:41-53.10.1016/j.ab.2007.05.00217570334]Open DOISearch in Google Scholar
[52. Sharif M, Granell R, Johansen J, Clarke S, Elson C, Kirwan JR. Serum cartilage oligomeric matrix protein and other biomarker profiles in tibiofemoral and patellofemoral osteoarthritis of the knee. Rheumatology (Oxford). 2006; 45:522-6.10.1093/rheumatology/kei21616319098]Open DOISearch in Google Scholar
[53. Zivanovic S, Rackov LP, Vojvodic D, Vucetic D. Human cartilage glycoprotein 39-biomarker of joint damage in knee osteoarthritis. Int Orthop. 2009; 33:1165-70.10.1007/s00264-009-0747-8289896919308408]Open DOISearch in Google Scholar
[54. Aspden RM. Osteoarthritis: a problem of growth not decay? Rheumatology (Oxford). 2008; 47:1452-60.10.1093/rheumatology/ken19918495820]Open DOISearch in Google Scholar
[55. Ministry of Public Health of Thailand. Thai seniors encounter degenerative diseases. (online). 2010 [cited 15 June 2010]. Available from: http://www.moph.go.th/show_hotnew.php?idHot_new=30798.]Search in Google Scholar
[56. Sanchez-Sabate E, Alvarez L, Gil-Garay E, Munuera L, Vilaboa N. Identification of differentially expressed genes in trabecular bone from the iliac crest of osteoarthritic patients. Osteoarthritis Cartilage. 2009; 17:1106-14.10.1016/j.joca.2009.01.01019303468]Open DOISearch in Google Scholar
[57. Park HJ, Yoon SH, Zheng LT, Lee KH, Kim JW, Chung JH, et al. Association of the -2510A/G chemokine (C-C motif) ligand 2 polymorphism with knee osteoarthritis in a Korean population. Scand J Rheumatol. 2007; 36: 299-306.10.1080/0300974070128816517763208]Search in Google Scholar
[58. Valdes AM, Loughlin J, Timms KM, van Meurs JJ, Southam L, Wilson SG, et al. Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis. Am J Hum Genet. 2008; 82:1231-40.10.1016/j.ajhg.2008.04.006242720818471798]Open DOISearch in Google Scholar
[59. Schneider EM, Du W, Fiedler J, Hogel J, Gunther KP, Brenner H, et al. The (-765 G->C) promoter variant of the COX-2/PTGS2 gene is associated with a lower risk for end-stage hip and knee osteoarthritis. Ann Rheum Dis (online). 2010 Apr 8 [cited 15 June 2010]. Available from: http://ard.bmj.com/content/early/2010/03/02/ard.2009.124040.long.10.1136/ard.2009.12404020378913]Search in Google Scholar
[60. Attur M, Wang HY, Byers Kraus V, Bukowski JF, Aziz N, Krasnokutsky S, et al. Radiographic severity of knee osteoarthritis is conditional on interleukin-1 receptor antagonist gene variations. Ann Rheum Dis. 2010; 69: 856-61.10.1136/ard.2009.113043292514619934104]Search in Google Scholar
[61. Moxley G, Meulenbelt I, Chapman K, van Diujn CM, Eline Slagboom P, Neale MC, et al. Interleukin-1 region meta-analysis with osteoarthritis phenotypes. Osteoarthritis Cartilage. 2010; 18:200-7.10.1016/j.joca.2009.08.00619733643]Search in Google Scholar
[62. Sezgin M, Erdal ME, Altintas ZM, Ankarali HC, Barlas IO, Turkmen E, et al. Lack of association polymorphisms of the IL1RN, IL1A, and IL1B genes with knee osteoarthritis in Turkish patients. Clin Invest Med. 2007; 30:E86-92.10.25011/cim.v30i2.98417716546]Search in Google Scholar
[63. Livshits G, Zhai G, Hart DJ, Kato BS, Wang H, Williams FM, et al. Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford Study. Arthritis Rheum. 2009; 60:2037-45.10.1002/art.24598284182019565477]Search in Google Scholar
[64. Sakao K, Takahashi KA, Arai Y, Saito M, Honjo K, Hiraoka N, et al. Osteoblasts derived from osteophytes produce interleukin-6, interleukin-8, and matrix metalloproteinase-13 in osteoarthritis. J Bone Miner Metab. 2009; 27:412-23.10.1007/s00774-009-0058-619333684]Search in Google Scholar
[65. Gordon A, Kiss-Toth E, Stockley I, Eastell R, Wilkinson JM. Polymorphisms in the interleukin-1 receptor antagonist and interleukin-6 genes affect risk of osteolysis in patients with total hip arthroplasty. Arthritis Rheum. 2008; 58:3157-65.10.1002/art.2386318821666]Open DOISearch in Google Scholar
[66. Kamarainen OP, Solovieva S, Vehmas T, Luoma K, Riihimaki H, Ala-Kokko L, et al. Common interleukin-6 promoter variants associate with the more severe forms of distal interphalangeal osteoarthritis. Arthritis Res Ther. 2008; 10:R21.10.1186/ar2374237445818257935]Search in Google Scholar
[67. Joosten LA, Lubberts E, Durez P, Helsen MM, Jacobs MJ, Goldman M, et al. Role of interleukin-4 and interleukin-10 in murine collagen-induced arthritis. Protective effect of interleukin-4 and interleukin-10 treatment on cartilage destruction. Arthritis Rheum. 1997; 40:249-60.10.1002/art.17804002099041936]Search in Google Scholar
[68. Fytili P, Giannatou E, Karachalios T, Malizos K, Tsezou A. Interleukin-10G and interleukin-10R microsatellite polymorphisms and osteoarthritis of the knee. Clin Exp Rheumatol. 2005; 23:621-7.]Search in Google Scholar
[69. Riyazi N, Kurreeman FA, Huizinga TW, Dekker FW, Stoeken-Rijsbergen G, Kloppenburg M. The role of interleukin 10 promoter polymorphisms in the susceptibility of distal interphalangeal osteoarthritis. J Rheumatol. 2005; 32:1571-5.]Search in Google Scholar
[70. Rovetta G, Buffrini L, Monteforte P, Grignolo MC, Molfetta L. HLA-DRB1alleles and osteoarthritis in a group of patients living in Liguria-Italy. Minerva Med. 2006; 97:271-5.]Search in Google Scholar
[71. Moos V, Menard J, Sieper J, Sparmann M, Muller B. Association of HLA-DRB1*02 with osteoarthritis in a cohort of 106 patients. Rheumatology (Oxford). 2002; 41:666-9.10.1093/rheumatology/41.6.66612048293]Search in Google Scholar
[72. Riyazi N, Spee J, Huizinga TW, Schreuder GM, de Vries RR, Dekker FW, et al. HLA class II is associated with distal interphalangeal osteoarthritis. Ann Rheum Dis. 2003; 62:227-30.10.1136/ard.62.3.227175446612594107]Open DOISearch in Google Scholar
[73. Wakitani S, Imoto K, Mazuka T, Kim S, Murata N, Yoneda M. Japanese generalised osteoarthritis was associated with HLA class I-a study of HLA-A, B, Cw, DQ, DR in 72 patients. Clin Rheumatol. 2001; 20: 417-9.10.1007/s10067017000611771525]Open DOISearch in Google Scholar
[74. Jiang Q, Shi D, Yi L, Ikegawa S, Wang Y, Nakamura T, et al. Replication of the association of the aspartic acid repeat polymorphism in the asporin gene with kneeosteoarthritis susceptibility in Han Chinese. J Hum Genet. 2006; 51:1068-72.10.1007/s10038-006-0065-617024313]Open DOISearch in Google Scholar
[75. Kaliakatsos M, Tzetis M, Kanavakis E, Fytili P, Chouliaras G, Karachalios T, et al. Asporin and knee osteoarthritis in patients of Greek origin. Osteoarthritis Cartilage. 2006; 14:609-11.10.1016/j.joca.2005.10.01216377215]Open DOISearch in Google Scholar
[76. Song JH, Lee HS, Kim CJ, Cho YG, Park YG, Nam SW, et al. Aspartic acid repeat polymorphism of the asporin gene with susceptibility to osteoarthritis of the knee in a Korean population. Knee. 2008; 15:191-5.10.1016/j.knee.2007.11.00518178444]Open DOISearch in Google Scholar
[77. Nakamura T, Shi D, Tzetis M, Rodriguez-Lopez J, Miyamoto Y, Tsezou A, et al. Meta-analysis of association between the ASPN D-repeat and osteoarthritis. Hum Mol Genet. 2007; 16:1676-81.10.1093/hmg/ddm11517517696]Open DOISearch in Google Scholar
[78. Rodriguez-Lopez J, Pombo-Suarez M, Liz M, Gomez- Reino JJ, Gonzalez A. Lack of association of a variable number of aspartic acid residues in the asporin gene with osteoarthritis susceptibility: case-control studies in Spanish Caucasians. Arthritis Res Ther. 2006; 8:R55.10.1186/ar1920]Search in Google Scholar
[79. Shi D, Nakamura T, Dai J, Yi L, Qin J, Chen D, et al. Association of the aspartic acid-repeat polymorphism in the asporin gene with age at onset of knee osteoarthritis in Han Chinese population. J Hum Genet. 2007; 52:664-7.10.1007/s10038-007-0166-x]Open DOISearch in Google Scholar
[80. Meulenbelt I, Bijkerk C, De Wildt SC, Miedema HS, Breedveld FC, Pols HA, et al. Haplotype analysis of three polymorphisms of the COL2A1 gene and associations with generalised radiological osteoarthritis. Ann Hum Genet. 1999; 63:393-400.10.1046/j.1469-1809.1999.6350393.x]Open DOISearch in Google Scholar
[81. Ikeda T, Mabuchi A, Fukuda A, Kawakami A, Ryo Y, Yamamoto S, et al. Association analysis of single nucleotide polymorphisms in cartilage-specific collagen genes with knee and hip osteoarthritis in the Japanese population. J Bone Miner Res. 2002; 17:1290-6.10.1359/jbmr.2002.17.7.1290]Open DOISearch in Google Scholar
[82. Chen HC, Shah SH, Li YJ, Stabler TV, Jordan JM, Kraus VB. Inverse association of general joint hypermobility with hand and knee osteoarthritis and serum cartilage oligomeric matrix protein levels. Arthritis Rheum. 2008; 58:3854-64.10.1002/art.24319]Open DOISearch in Google Scholar
[83. Pullig O, Weseloh G, Klatt AR, Wagener R, Swoboda B. Matrilin-3 in human articular cartilage: increased expression in osteoarthritis. Osteoarthritis Cartilage. 2002; 10:253-63.10.1053/joca.2001.0508]Open DOISearch in Google Scholar
[84. Min JL, Meulenbelt I, Riyazi N, Kloppenburg M, Houwing-Duistermaat JJ, Seymour AB, et al. Association of matrilin-3 polymorphisms with spinal disc degeneration and osteoarthritis of the first carpometacarpal joint of the hand. Ann Rheum Dis. 2006; 65:1060-6.10.1136/ard.2005.045153]Open DOISearch in Google Scholar
[85. Pullig O, Tagariello A, Schweizer A, Swoboda B, Schaller P, Winterpacht A. MATN3 (matrilin-3) sequence variation (pT303M) is a risk factor for osteoarthritis of the CMC1 joint of the hand, but not for knee osteoarthritis. Ann Rheum Dis. 2007; 66: 279-80.10.1136/ard.2006.058263]Search in Google Scholar
[86. Klatt AR, Klinger G, Paul-Klausch B, Kuhn G, Renno JH, Wagener R, et al. Matrilin-3 activates the expression of osteoarthritis-associated genes in primary human chondrocytes. FEBS Lett. 2009; 583:3611-7.10.1016/j.febslet.2009.10.035]Open DOISearch in Google Scholar
[87. Pullig O, Weseloh G, Gauer S, Swoboda B. Osteopontin is expressed by adult human osteoarthritic chondrocytes: protein and mRNA analysis of normal and osteoarthritic cartilage. Matrix Biol. 2000; 19: 245-55.10.1016/S0945-053X(00)00068-8]Open DOISearch in Google Scholar
[88. Gao SG, Li KH, Zeng KB, Tu M, Xu M, Lei GH. Elevated osteopontin level of synovial fluid and articular cartilage is associated with disease severity in knee osteoarthritis patients. Osteoarthritis Cartilage. 2010; 18, 82-7.]Search in Google Scholar
[89. Szekanecz Z, Haines GK, Harlow LA, Shah MR, Fong TW, Fu R, et al. Increased synovial expression of transforming growth factor (TGF)-beta receptor endoglin and TGF-beta 1 in rheumatoid arthritis: possible interactions in the pathogenesis of the disease. Clin Immunol Immunopathol. 1995; 76:187-94.10.1006/clin.1995.1114]Open DOISearch in Google Scholar
[90. Lane NE, Lian K, Nevitt MC, Zmuda JM, Lui L, Li J, et al. Frizzled-related protein variants are risk factors for hip osteoarthritis. Arthritis Rheum. 2006; 54: 1246-54.10.1002/art.21673]Open DOISearch in Google Scholar
[91. Min JL, Meulenbelt I, Riyazi N, Kloppenburg M, Houwing-Duistermaat JJ, Seymour AB, et al. Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites. Arthritis Rheum. 2005; 52:1077-80.10.1002/art.20993]Open DOISearch in Google Scholar
[92. Rodriguez-Lopez J, Pombo-Suarez M, Liz M, Gomez- Reino JJ, Gonzalez A. Further evidence of the role of frizzled-related protein gene polymorphisms in osteoarthritis. Ann Rheum Dis. 2007; 66:1052-5.10.1136/ard.2006.065938]Open DOISearch in Google Scholar
[93. Blom AB, Brockbank SM, van Lent PL, van Beuningen HM, Geurts J, Takahashi N, et al. Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: prominent role of Wnt-induced signaling protein 1. Arthritis Rheum. 2009; 60:501-12.10.1002/art.24247]Open DOISearch in Google Scholar
[94. Nakase T, Miyaji T, Tomita T, Kaneko M, Kuriyama K, Myoui A, et al. Localization of bone morphogenetic protein-2 in human osteoarthritic cartilage and osteophyte. Osteoarthritis Cartilage. 2003; 11:278-84.10.1016/S1063-4584(03)00004-9]Open DOISearch in Google Scholar
[95. Southam L, Dowling B, Ferreira A, Marcelline L, Mustafa Z, Chapman K, et al. Microsatellite association mapping of a primary osteoarthritis susceptibility locus on chromosome 6p12.3-q13. Arthritis Rheum. 2004; 50: 3910-4.10.1002/art.20634]Open DOISearch in Google Scholar
[96. Chubinskaya S, Frank BS, Michalska M, Kumar B, Merrihew CA, Thonar EJ, et al. Osteogenic protein 1 in synovial fluid from patients with rheumatoid arthritis or osteoarthritis: relationship with disease and levels of hyaluronan and antigenic keratan sulfate. Arthritis Res Ther. 2006; 8:R73.10.1186/ar1947]Search in Google Scholar
[97. Settle SH, Jr., Rountree RB, Sinha A, Thacker A, Higgins K, Kingsley DM. Multiple joint and skeletal patterning defects caused by single and double mutations in the mouse Gdf6 and Gdf5 genes. Dev Biol. 2003; 254: 116-30.10.1016/S0012-1606(02)00022-2]Open DOISearch in Google Scholar
[98. Solovieva S, Hirvonen A, Siivola P, Vehmas T, Luoma K, Riihimaki H, et al. Vitamin D receptor gene polymorphisms and susceptibility of hand osteoarthritis in Finnish women. Arthritis Res Ther. 2006; 8:R20.10.1186/ar1874152654916507122]Search in Google Scholar
[99. Hulejova H, Baresova V, Klezl Z, Polanska M, Adam M, Senolt L. Increased level of cytokines and matrix metalloproteinases in osteoarthritic subchondral bone. Cytokine. 2007; 38:151-6. 10.1016/j.cyto.2007.06.00117689092]Open DOISearch in Google Scholar