<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>The prevalence of diabetes mellitus is increasing worldwide. Endothelial dysfunction plays a critical role in the pathophysiology of diabetes-related vascular complications. Several studies have shown that restoring blood glucose levels failed to reduce the incidence of major cardiovascular events in diabetic population, hence confirming the idea of “metabolic/hyperglycemic memory”. The major pathomechanism is, most likely, represented by the overproduction of reactive oxygen species (ROS). The purpose of this minireview is to summarize current knowledge about the mechanisms of metabolic memory and the impact of cardiovascular medication on this phenomenon, respectively.</p>
</abstract>

The prevalence of diabetes mellitus is increasing worldwide. Endothelial dysfunction plays a critical role in the pathophysiology of diabetes-related vascular complications. Several studies have shown that restoring blood glucose levels failed to reduce the incidence of major cardiovascular events in diabetic population, hence confirming the idea of “metabolic/hyperglycemic memory”. The major pathomechanism is, most likely, represented by the overproduction of reactive oxygen species (ROS). The purpose of this minireview is to summarize current knowledge about the mechanisms of metabolic memory and the impact of cardiovascular medication on this phenomenon, respectively.

Metabolic Memory in Diabetes – Mechanistic Insights and the Impact of Cardiovascular Medication

Department of Cardiology – Cardiology II

„Victor Babes” University of Medicine and Pharmacy

Research Center for Cardiovascular Diseases, Institute of Cardiovascular Diseases

Center for Translational Research and Systems Medicine

Department of Functional Sciences – Pathophysiology

Department of Cardiology – Cardiovascular Surgery

Romanian Journal of Cardiology

This work is licensed under the Creative Commons Attribution 4.0 International License.

The prevalence of diabetes mellitus is increasing worldwide. Endothelial dysfunction plays a critical role in the pathophysiology of diabetes-related vascular...

Metabolic Memory in Diabetes – Mechanistic Insights and the Impact of Cardiovascular Medication

Article Category: Review

Online veröffentlicht: 05. Mai 2022

Seitenbereich: 511 - 516

DOI: https://doi.org/10.47803/rjc.2021.31.3.511

Schlüsselwörter
diabetes mellitus, metabolic memory, oxidative stress, cardiovascular medication

© 2021 Raluca Sosdean et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Metabolic Memory in Diabetes – Mechanistic Insights and the Impact of Cardiovascular Medication

Article Category: Review

Online veröffentlicht: 05. Mai 2022

Seitenbereich: 511 - 516

DOI: https://doi.org/10.47803/rjc.2021.31.3.511

Schlüsselwörterdiabetes mellitus, metabolic memory, oxidative stress, cardiovascular medication

© 2021 Raluca Sosdean et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Schlüsselwörter
diabetes mellitus, metabolic memory, oxidative stress, cardiovascular medication