<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Severe aortic stenosis (AS) is the most common valvular heart disease, with an increasing prevalence due to age-related degenerative modifications of the valve. Once AS becomes symptomatic, the survival of patients is significantly reduced with an annual mortality rate of 25%. Depending on surgical risk, anatomical and technical aspects, and the patient’s option, correction can be made either by surgical valve replacement (SAVR) or by transcatheter aortic valve implantation (TAVI). Although aortic valve implantation brings relief of symptoms, there is little data on the quality of life (QoL) of patients undergoing TAVI and the factors that directly influence it. Even if age and comorbidities are known modifiers of survival, there is no specific tool to assess the impact of AS and to determine the appropriate treatment strategy.</p>
</abstract>

Severe aortic stenosis (AS) is the most common valvular heart disease, with an increasing prevalence due to age-related degenerative modifications of the valve. Once AS becomes symptomatic, the survival of patients is significantly reduced with an annual mortality rate of 25%. Depending on surgical risk, anatomical and technical aspects, and the patient’s option, correction can be made either by surgical valve replacement (SAVR) or by transcatheter aortic valve implantation (TAVI). Although aortic valve implantation brings relief of symptoms, there is little data on the quality of life (QoL) of patients undergoing TAVI and the factors that directly influence it. Even if age and comorbidities are known modifiers of survival, there is no specific tool to assess the impact of AS and to determine the appropriate treatment strategy.

Survival, Functional Capacity and Quality of Life after Transcatheter Aortic Valve Implantation: Present Considerations and Future Perspectives

„Carol Davila” University of Medicine and Pharmacy

ARES Excellence Centers in Interventional Cardiology and Radiology, Monza Hospital

Romanian Journal of Cardiology

This work is licensed under the Creative Commons Attribution 4.0 International License.

Severe aortic stenosis (AS) is the most common valvular heart disease, with an increasing prevalence due to age-related degenerative modifications of the...

Variable	OR	95%CI	P-value
Age	1.01	0.96–1.07	0.647
Gender	1.13	0.56–2.27	0.737
Eq5D-5L index on baseline	10.62	2.32–48.52	0.002
Current smoker	3.21	1.06–9.77	0.040
Peripheral artery disease	1.40	0.73–2.66	0.312
Renal dysfunction	2.12	1.11–4.04	0.023
Limitation of mobility (5mGST)	2.29	1.35–6.17	0.006
Frailty (EFS)	2.25	1.07–4.70	0.003

Domain	Questions	Maximum points
Physical symptoms	1, 14	14
Physical limitations	3, 6, 7, 15	28
Emotional impact and expectations	16	7
Emotional impact	2,8, 9, 10, 11, 12, 13	49
Social limitations	4,5	14
		Total score=112

Survival, Functional Capacity and Quality of Life after Transcatheter Aortic Valve Implantation: Present Considerations and Future Perspectives

Article Category: Review

Online veröffentlicht: 03. Mai 2022

Seitenbereich: 319 - 325

DOI: https://doi.org/10.47803/rjc.2021.31.2.319

Schlüsselwörter
aortic stenosis, transcatheter aortic valve implantation, quality of life, mortality, frailty

© 2021 Crina-Ioana Radulescu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Figure 1

Figure 2

Figure 3

Predictors of deterioration of quality of life 1 year after TAVI (from Goudzwaard et al., 2020)

Summary of the TASQ, Toronto Aortic Stenosis Quality of Life Questionnaire

Survival, Functional Capacity and Quality of Life after Transcatheter Aortic Valve Implantation: Present Considerations and Future Perspectives

Article Category: Review

Online veröffentlicht: 03. Mai 2022

Seitenbereich: 319 - 325

DOI: https://doi.org/10.47803/rjc.2021.31.2.319

Schlüsselwörteraortic stenosis, transcatheter aortic valve implantation, quality of life, mortality, frailty

© 2021 Crina-Ioana Radulescu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Figure 1

Figure 2

Figure 3

Predictors of deterioration of quality of life 1 year after TAVI (from Goudzwaard et al., 2020)

Summary of the TASQ, Toronto Aortic Stenosis Quality of Life Questionnaire

Schlüsselwörter
aortic stenosis, transcatheter aortic valve implantation, quality of life, mortality, frailty