Anti-inflammatory Effect of Gambier Catechin (Uncaria gambir Roxb) on Rheumatoid Arthritis: A Review
, und | 03. Jan. 2024
Online veröffentlicht: 03. Jan. 2024
Seitenbereich: 92 - 97
Eingereicht: 30. Juli 2023
Akzeptiert: 27. Sept. 2023
DOI: https://doi.org/10.3889/seejim.2023.6055
Schlüsselwörter
© 2023 Refa Rahmaddiansyah et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
BACKGROUND
Rheumatoid arthritis (RA) is a chronic inflammatory disease of the joints and varies in severity in patients. Inflammation in the joints causes high levels of systemic pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) which have an impact on permanent damage to the joints. Until now, the treatment of RA is only symptomatic, without being able to prevent the progression of damage to the joints, and this treatment also causes side effects such as gastrointestinal and cardiovascular toxicity. Therefore, many patients are looking for alternative medicine to complement their treatment.
METHODS
This research was a narrative review that was performed using PubMed, Science Direct, and Google Scholar using pre-clinical and clinical studies which aim to determine whether the therapeutic mechanism of gambier catechin (
RESULTS
The gambier plant is a typical plant of West Sumatra, which is rich in phytochemicals. The active compounds in gambier are catechins which are classified as flavanols/flavonoids. Catechins are compounds that are well-known as antioxidant, anti-inflammatory compounds, the highest found in gambier plants. Catechins affect the expression of inflammation-related genes and proteins such as TNF-α, IL-1, and show their anti-inflammatory roles. This research is a literature review using secondary data from original research based on
CONCLUSION
It can be concluded that gambier catechins have the potential as a candidate for RA therapy. This, if developed, can certainly improve the health status of the community locally and globally.