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Gut Microbiota, Circulating Metabolites and Risk of Endometriosis: A Two-Step Mendelian Randomization Study

  
13. Dez. 2024

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COVER HERUNTERLADEN

Ahmadi S, Taghizadieh M, Mehdizadehfar E, Hasani A, Khalili Fard J, Feizi H, Hamishehkar H, Ansarin M, Yekani M, Memar MY. Gut microbiota in neurological diseases: Melatonin plays an important regulatory role. Biomed Pharmacother. 2024 May;174:116487 https://doi.org/10.1016/j.biopha.2024.116487 Ahmadi S Taghizadieh M Mehdizadehfar E Hasani A Khalili Fard J Feizi H Hamishehkar H Ansarin M Yekani M Memar MY. Gut microbiota in neurological diseases: Melatonin plays an important regulatory role . Biomed Pharmacother . 2024 May ; 174 : 116487 https://doi.org/10.1016/j.biopha.2024.116487 Search in Google Scholar

Ahn SH, Singh V, Tayade C. Biomarkers in endometriosis: Challenges and opportunities. Fertil Steril. 2017 Mar;107(3):523–532. https://doi.org/10.1016/j.fertnstert.2017.01.009 Ahn SH Singh V Tayade C. Biomarkers in endometriosis: Challenges and opportunities . Fertil Steril . 2017 Mar ; 107 ( 3 ): 523 532 . https://doi.org/10.1016/j.fertnstert.2017.01.009 Search in Google Scholar

Allaire C, Bedaiwy MA, Yong PJ. Diagnosis and management of endometriosis. CMAJ. 2023 Mar;195(10):E363–E371. https://doi.org/10.1503/cmaj.220637 Allaire C Bedaiwy MA Yong PJ. Diagnosis and management of endometriosis . CMAJ . 2023 Mar ; 195 ( 10 ): E363 E371 . https://doi.org/10.1503/cmaj.220637 Search in Google Scholar

Anastasiu CV, Moga MA, Elena Neculau A, Bălan A, Scârneciu I, Dragomir RM, Dull AM, Chicea LM. Biomarkers for the noninvasive diagnosis of endometriosis: State of the art and future perspectives. Int J Mol Sci. 2020 Mar;21(5):1750. https://doi.org/10.3390/ijms21051750 Anastasiu CV Moga MA Elena Neculau A Bălan A Scârneciu I Dragomir RM Dull AM Chicea LM. Biomarkers for the noninvasive diagnosis of endometriosis: State of the art and future perspectives . Int J Mol Sci . 2020 Mar ; 21 ( 5 ): 1750 . https://doi.org/10.3390/ijms21051750 Search in Google Scholar

Asghari S, Valizadeh A, Aghebati-Maleki L, Nouri M, Yousefi M. Endometriosis: Perspective, lights, and shadows of etiology. Biomed Pharmacother. 2018 Oct;106:163–174. https://doi.org/10.1016/j.biopha.2018.06.109 Asghari S Valizadeh A Aghebati-Maleki L Nouri M Yousefi M. Endometriosis: Perspective, lights, and shadows of etiology . Biomed Pharmacother . 2018 Oct ; 106 : 163 174 . https://doi.org/10.1016/j.biopha.2018.06.109 Search in Google Scholar

Ata B, Yildiz S, Turkgeldi E, Brocal VP, Dinleyici EC, Moya A, Urman B. The endobiota study: Comparison of vaginal, cervical and gut microbiota between women with stage ¾ endometriosis and healthy controls. Sci Rep. 2019 Feb;9(1):2204. https://doi.org/10.1038/s41598-019-39700-6 Ata B Yildiz S Turkgeldi E Brocal VP Dinleyici EC Moya A Urman B. The endobiota study: Comparison of vaginal, cervical and gut microbiota between women with stage ¾ endometriosis and healthy controls . Sci Rep . 2019 Feb ; 9 ( 1 ): 2204 . https://doi.org/10.1038/s41598-019-39700-6 Search in Google Scholar

Azpiroz MA, Orguilia L, Palacio MI, Malpartida A, Mayol S, Mor G, Gutiérrez G. Potential biomarkers of infertility associated with microbiome imbalances. Am J Reprod Immunol. 2021 Oct; 86(4):e13438. https://doi.org/10.1111/aji.13438 Azpiroz MA Orguilia L Palacio MI Malpartida A Mayol S Mor G Gutiérrez G. Potential biomarkers of infertility associated with microbiome imbalances . Am J Reprod Immunol . 2021 Oct ; 86 ( 4 ): e13438 . https://doi.org/10.1111/aji.13438 Search in Google Scholar

Bailey MT, Coe CL. Endometriosis is associated with an altered profile of intestinal microflora in female rhesus monkeys. Hum Reprod. 2002 Jul;17(7):1704–1708. https://doi.org/10.1093/humrep/17.7.1704 Bailey MT Coe CL. Endometriosis is associated with an altered profile of intestinal microflora in female rhesus monkeys . Hum Reprod . 2002 Jul ; 17 ( 7 ): 1704 1708 . https://doi.org/10.1093/humrep/17.7.1704 Search in Google Scholar

Barko PC, McMichael MA, Swanson KS, Williams DA. The gastrointestinal microbiome: A review. J Vet Intern Med. 2018 Jan;32(1):9–25. https://doi.org/10.1111/jvim.14875 Barko PC McMichael MA Swanson KS Williams DA. The gastrointestinal microbiome: A review . J Vet Intern Med . 2018 Jan ; 32 ( 1 ): 9 25 . https://doi.org/10.1111/jvim.14875 Search in Google Scholar

Birney E. Mendelian randomization. Cold Spring Harb Perspect Med. 2022 May;12(4):a041302. https://doi.org/10.1101/cshperspect.a041302 Birney E. Mendelian randomization . Cold Spring Harb Perspect Med . 2022 May ; 12 ( 4 ): a041302 . https://doi.org/10.1101/cshperspect.a041302 Search in Google Scholar

Bjorkman S, Taylor HS. MicroRNAs in endometriosis: Biological function and emerging biomarker candidates†. Biol Reprod. 2019 May;100(5):1135–1146. https://doi.org/10.1093/biolre/ioz014 Bjorkman S Taylor HS. MicroRNAs in endometriosis: Biological function and emerging biomarker candidates† . Biol Reprod . 2019 May ; 100 ( 5 ): 1135 1146 . https://doi.org/10.1093/biolre/ioz014 Search in Google Scholar

Bowden J, Holmes MV. Meta-analysis and Mendelian randomization: A review. Res Synth Methods. 2019 Dec;10(4):486–496. https://doi.org/10.1002/jrsm.1346 Bowden J Holmes MV. Meta-analysis and Mendelian randomization: A review . Res Synth Methods . 2019 Dec ; 10 ( 4 ): 486 496 . https://doi.org/10.1002/jrsm.1346 Search in Google Scholar

Buhaş MC, Gavrilaş LI, Candrea R, Cătinean A, Mocan A, Miere D, Tătaru A. Gut microbiota in psoriasis. Nutrients. 2022 Jul; 14(14):2970. https://doi.org/10.3390/nu14142970 Buhaş MC Gavrilaş LI Candrea R Cătinean A Mocan A Miere D Tătaru A. Gut microbiota in psoriasis . Nutrients . 2022 Jul ; 14 ( 14 ): 2970 . https://doi.org/10.3390/nu14142970 Search in Google Scholar

Burgess S, Thompson SG. Interpreting findings from Mendelian randomization using the MR-Egger method. Eur J Epidemiol. 2017 May;32(5):377–389. https://doi.org/10.1007/s10654-017-0255-x Burgess S Thompson SG. Interpreting findings from Mendelian randomization using the MR-Egger method . Eur J Epidemiol . 2017 May ; 32 ( 5 ): 377 389 . https://doi.org/10.1007/s10654-017-0255-x Search in Google Scholar

Burgess S, Thompson SG; CRP CHD Genetics Collaboration. Avoiding bias from weak instruments in Mendelian randomization studies. Int J Epidemiol. 2011 Jun;40(3):755–764. https://doi.org/10.1093/ije/dyr036 Burgess S Thompson SG CRP CHD Genetics Collaboration ,. Avoiding bias from weak instruments in Mendelian randomization studies . Int J Epidemiol . 2011 Jun ; 40 ( 3 ): 755 764 . https://doi.org/10.1093/ije/dyr036 Search in Google Scholar

Cao Z, Wu Y, Li Q, Li Y, Wu J. A causal relationship between childhood obesity and risk of osteoarthritis: Results from a two-sample Mendelian randomization analysis. Ann Med. 2022 Dec;54(1):1636–1645. https://doi.org/10.1080/07853890.2022.2085883 Cao Z Wu Y Li Q Li Y Wu J. A causal relationship between childhood obesity and risk of osteoarthritis: Results from a two-sample Mendelian randomization analysis . Ann Med . 2022 Dec ; 54 ( 1 ): 1636 1645 . https://doi.org/10.1080/07853890.2022.2085883 Search in Google Scholar

Chadchan SB, Cheng M, Parnell LA, Yin Y, Schriefer A, Mysorekar IU, Kommagani R. Antibiotic therapy with metronidazole reduces endometriosis disease progression in mice: A potential role for gut microbiota. Hum Reprod. 2019 Jun;34(6):1106–1116. https://doi.org/10.1093/humrep/dez041 Chadchan SB Cheng M Parnell LA Yin Y Schriefer A Mysorekar IU Kommagani R. Antibiotic therapy with metronidazole reduces endometriosis disease progression in mice: A potential role for gut microbiota . Hum Reprod . 2019 Jun ; 34 ( 6 ): 1106 1116 . https://doi.org/10.1093/humrep/dez041 Search in Google Scholar

Chen F, Dai X, Zhou CC, Li KX, Zhang YJ, Lou XY, Zhu YM, Sun YL, Peng BX, Cui W. Integrated analysis of the faecal metagenome and serum metabolome reveals the role of gut microbiome-associated metabolites in the detection of colorectal cancer and adenoma. Gut. 2022 Jul;71(7):1315–1325. https://doi.org/10.1136/gutjnl-2020-323476 Chen F Dai X Zhou CC Li KX Zhang YJ Lou XY Zhu YM Sun YL Peng BX Cui W. Integrated analysis of the faecal metagenome and serum metabolome reveals the role of gut microbiome-associated metabolites in the detection of colorectal cancer and adenoma . Gut . 2022 Jul ; 71 ( 7 ): 1315 1325 . https://doi.org/10.1136/gutjnl-2020-323476 Search in Google Scholar

Cheng H, Garrick DJ, Fernando RL. Efficient strategies for leave-one-out cross validation for genomic best linear unbiased prediction. J Anim Sci Biotechnol. 2017 May;8:38. https://doi.org/10.1186/s40104-017-0164-6 Cheng H Garrick DJ Fernando RL. Efficient strategies for leave-one-out cross validation for genomic best linear unbiased prediction . J Anim Sci Biotechnol . 2017 May ; 8 : 38 . https://doi.org/10.1186/s40104-017-0164-6 Search in Google Scholar

Clemente JC, Manasson J, Scher JU. The role of the gut microbiome in systemic inflammatory disease. BMJ. 2018 Jan 8;360:j5145. https://doi.org/10.1136/bmj.j5145 Clemente JC Manasson J Scher JU. The role of the gut microbiome in systemic inflammatory disease . BMJ . 2018 Jan 8 ; 360 : j5145 . https://doi.org/10.1136/bmj.j5145 Search in Google Scholar

Czyzyk A, Podfigurna A, Szeliga A, Meczekalski B. Update on endometriosis pathogenesis. Minerva Ginecol. 2017 Oct;69(5):447–461. https://doi.org/10.23736/S0026-4784.17.04048-5 Czyzyk A Podfigurna A Szeliga A Meczekalski B. Update on endometriosis pathogenesis . Minerva Ginecol . 2017 Oct ; 69 ( 5 ): 447 461 . https://doi.org/10.23736/S0026-4784.17.04048-5 Search in Google Scholar

Del Chierico F, Rapini N, Deodati A, Matteoli MC, Cianfarani S, Putignani L. Pathophysiology of type 1 diabetes and gut microbiota role. Int J Mol Sci. 2022 Nov;23(23):14650. https://doi.org/10.3390/ijms232314650 Del Chierico F Rapini N Deodati A Matteoli MC Cianfarani S Putignani L. Pathophysiology of type 1 diabetes and gut microbiota role . Int J Mol Sci . 2022 Nov ; 23 ( 23 ): 14650 . https://doi.org/10.3390/ijms232314650 Search in Google Scholar

Della Corte L, Di Filippo C, Gabrielli O, Reppuccia S, La Rosa VL, Ragusa R, Fichera M, Commodari E, Bifulco G, Giampaolino P. The Burden of endometriosis on women’s lifespan: A narrative overview on quality of life and psychosocial wellbeing. Int J Environ Res Public Health. 2020 Jun;17(13):4683. https://doi.org/10.3390/ijerph17134683 Della Corte L Di Filippo C Gabrielli O Reppuccia S La Rosa VL Ragusa R Fichera M Commodari E Bifulco G Giampaolino P. The Burden of endometriosis on women’s lifespan: A narrative overview on quality of life and psychosocial wellbeing . Int J Environ Res Public Health . 2020 Jun ; 17 ( 13 ): 4683 . https://doi.org/10.3390/ijerph17134683 Search in Google Scholar

Dutta M, Joshi M, Srivastava S, Lodh I, Chakravarty B, Chaudhury K. A metabonomics approach as a means for identification of potential biomarkers for early diagnosis of endometriosis. Mol Biosyst. 2012 Oct;8(12):3281–3287. https://doi.org/10.1039/c2mb25353d Dutta M Joshi M Srivastava S Lodh I Chakravarty B Chaudhury K. A metabonomics approach as a means for identification of potential biomarkers for early diagnosis of endometriosis . Mol Biosyst . 2012 Oct ; 8 ( 12 ): 3281 3287 . https://doi.org/10.1039/c2mb25353d Search in Google Scholar

Dutta M, Singh B, Joshi M, Das D, Subramani E, Maan M, Jana SK, Sharma U, Das S, Dasgupta S, et al. Metabolomics reveals perturbations in endometrium and serum of minimal and mild endometriosis. Sci Rep. 2018 Apr;8(1):6466. https://doi.org/10.1038/s41598-018-23954-7 Dutta M Singh B Joshi M Das D Subramani E Maan M Jana SK Sharma U Das S Dasgupta S et al. Metabolomics reveals perturbations in endometrium and serum of minimal and mild endometriosis . Sci Rep . 2018 Apr ; 8 ( 1 ): 6466 . https://doi.org/10.1038/s41598-018-23954-7 Search in Google Scholar

Elkabets M, Ribeiro VS, Dinarello CA, Ostrand-Rosenberg S, Di Santo JP, Apte RN, Vosshenrich CA. IL-1β regulates a novel myeloid-derived suppressor cell subset that impairs NK cell development and function. Eur J Immunol. 2010 Dec;40(12):3347–3357. https://doi.org/10.1002/eji.201041037 Elkabets M Ribeiro VS Dinarello CA Ostrand-Rosenberg S Di Santo JP Apte RN Vosshenrich CA. IL-1β regulates a novel myeloid-derived suppressor cell subset that impairs NK cell development and function . Eur J Immunol . 2010 Dec ; 40 ( 12 ): 3347 3357 . https://doi.org/10.1002/eji.201041037 Search in Google Scholar

Franzosa EA, Sirota-Madi A, Avila-Pacheco J, Fornelos N, Haiser HJ, Reinker S, Vatanen T, Hall AB, Mallick H, McIver LJ, et al. Gut microbiome structure and metabolic activity in inflammatory bowel disease. Nat Microbiol. 2019 Feb;4(2):293–305. https://doi.org/10.1038/s41564-018-0306-4 Franzosa EA Sirota-Madi A Avila-Pacheco J Fornelos N Haiser HJ Reinker S Vatanen T Hall AB Mallick H McIver LJ et al. Gut microbiome structure and metabolic activity in inflammatory bowel disease . Nat Microbiol . 2019 Feb ; 4 ( 2 ): 293 305 . https://doi.org/10.1038/s41564-018-0306-4 Search in Google Scholar

Frayne J, Milroy T, Simonis M, Lam A. Challenges in diagnosing and managing endometriosis in general practice: A Western Australian qualitative study. Aust J Gen Pract. 2023 Aug;52(8):547–555. https://doi.org/10.31128/AJGP-10-22-6579 Frayne J Milroy T Simonis M Lam A. Challenges in diagnosing and managing endometriosis in general practice: A Western Australian qualitative study . Aust J Gen Pract . 2023 Aug ; 52 ( 8 ): 547 555 . https://doi.org/10.31128/AJGP-10-22-6579 Search in Google Scholar

Garcia Garcia JM, Vannuzzi V, Donati C, Bernacchioni C, Bruni P, Petraglia F. Endometriosis: Cellular and molecular mechanisms leading to fibrosis. Reprod Sci. 2023 May;30(5):1453–1461. https://doi.org/10.1007/s43032-022-01083-x Garcia Garcia JM Vannuzzi V Donati C Bernacchioni C Bruni P Petraglia F. Endometriosis: Cellular and molecular mechanisms leading to fibrosis . Reprod Sci . 2023 May ; 30 ( 5 ): 1453 1461 . https://doi.org/10.1007/s43032-022-01083-x Search in Google Scholar

Ghazi N, Arjmand M, Akbari Z, Mellati AO, Saheb-Kashaf H, Zamani Z. 1H NMR-based metabolomics approaches as non-invasive tools for diagnosis of endometriosis. Int J Reprod Biomed. 2016 Jan;14(1):1–8. Ghazi N Arjmand M Akbari Z Mellati AO Saheb-Kashaf H Zamani Z. 1H NMR-based metabolomics approaches as non-invasive tools for diagnosis of endometriosis . Int J Reprod Biomed . 2016 Jan ; 14 ( 1 ): 1 8 . Search in Google Scholar

Gnona KM, Stewart WCL. Revisiting the Wald test in small casecontrol studies with a skewed covariate. Am J Epidemiol. 2022 Jul; 191(8):1508–1518. https://doi.org/10.1093/aje/kwac058 Gnona KM Stewart WCL. Revisiting the Wald test in small casecontrol studies with a skewed covariate . Am J Epidemiol . 2022 Jul ; 191 ( 8 ): 1508 1518 . https://doi.org/10.1093/aje/kwac058 Search in Google Scholar

Guo SW, Habiba M, Benagiano G. From retrograde menstruation to endometrial determinism and a brave new world of “root treatment” of endometriosis: Destiny or a fanciful utopia? Biomolecules. 2023 Feb 9;13(2):336. https://doi.org/10.3390/biom13020336 Guo SW Habiba M Benagiano G. From retrograde menstruation to endometrial determinism and a brave new world of “root treatment” of endometriosis: Destiny or a fanciful utopia? Biomolecules . 2023 Feb 9 ; 13 ( 2 ): 336 . https://doi.org/10.3390/biom13020336 Search in Google Scholar

Ha CWY, Martin A, Sepich-Poore GD, Shi B, Wang Y, Gouin K, Humphrey G, Sanders K, Ratnayake Y, Chan KSL, et al. Translocation of viable gut microbiota to mesenteric adipose drives formation of creeping fat in humans. Cell. 2020 Oct;183(3):666–683.e17. https://doi.org/10.1016/j.cell.2020.09.009 Ha CWY Martin A Sepich-Poore GD Shi B Wang Y Gouin K Humphrey G Sanders K Ratnayake Y Chan KSL et al. Translocation of viable gut microbiota to mesenteric adipose drives formation of creeping fat in humans . Cell . 2020 Oct ; 183 ( 3 ): 666 683 . e17 . https://doi.org/10.1016/j.cell.2020.09.009 Search in Google Scholar

Hemani G, Zheng J, Elsworth B, Wade KH, Haberland V, Baird D, Laurin C, Burgess S, Bowden J, Langdon R, et al. The MR-Base platform supports systematic causal inference across the human phenome. Elife. 2018 May;7:e34408. https://doi.org/10.7554/eLife.34408 Hemani G Zheng J Elsworth B Wade KH Haberland V Baird D Laurin C Burgess S Bowden J Langdon R et al. The MR-Base platform supports systematic causal inference across the human phenome . Elife . 2018 May ; 7 : e34408 . https://doi.org/10.7554/eLife.34408 Search in Google Scholar

Hou K, Wu ZX, Chen XY, Wang JQ, Zhang D, Xiao C, Zhu D, Koya JB, Wei L, Li J, et al. Microbiota in health and diseases. Signal Transduct Target Ther. 2022 Apr;7(1):135. https://doi.org/10.1038/s41392-022-00974-4 Hou K Wu ZX Chen XY Wang JQ Zhang D Xiao C Zhu D Koya JB Wei L Li J et al. Microbiota in health and diseases . Signal Transduct Target Ther . 2022 Apr ; 7 ( 1 ): 135 . https://doi.org/10.1038/s41392-022-00974-4 Search in Google Scholar

Iesanu MI, Zahiu CDM, Dogaru IA, Chitimus DM, Pircalabioru GG, Voiculescu SE, Isac S, Galos F, Pavel B, O’Mahony SM, et al. Melatonin-microbiome two-sided interaction in dysbiosis-associated conditions. Antioxidants. 2022 Nov;11(11):2244. https://doi.org/10.3390/antiox11112244 Iesanu MI Zahiu CDM Dogaru IA Chitimus DM Pircalabioru GG Voiculescu SE Isac S Galos F Pavel B O’Mahony SM et al. Melatonin-microbiome two-sided interaction in dysbiosis-associated conditions . Antioxidants . 2022 Nov ; 11 ( 11 ): 2244 . https://doi.org/10.3390/antiox11112244 Search in Google Scholar

Jana SK, Dutta M, Joshi M, Srivastava S, Chakravarty B, Chaudhury K. 1H NMR based targeted metabolite profiling for understanding the complex relationship connecting oxidative stress with endometriosis. Biomed Res Int. 2013;2013:329058. https://doi.org/10.1155/2013/329058 Jana SK Dutta M Joshi M Srivastava S Chakravarty B Chaudhury K. 1H NMR based targeted metabolite profiling for understanding the complex relationship connecting oxidative stress with endometriosis . Biomed Res Int . 2013 ; 2013 : 329058 . https://doi.org/10.1155/2013/329058 Search in Google Scholar

Jerman LF, Hey-Cunningham AJ. The role of the lymphatic system in endometriosis: A comprehensive review of the literature. Biol Reprod. 2015 Mar;92(3):64. https://doi.org/10.1095/biolreprod.114.124313 Jerman LF Hey-Cunningham AJ. The role of the lymphatic system in endometriosis: A comprehensive review of the literature . Biol Reprod . 2015 Mar ; 92 ( 3 ): 64 . https://doi.org/10.1095/biolreprod.114.124313 Search in Google Scholar

Jiang W, Lu G, Gao D, Lv Z, Li D. The relationships between the gut microbiota and its metabolites with thyroid diseases. Front Endocrinol. 2022 Aug;13:943408. https://doi.org/10.3389/fendo.2022.943408 Jiang W Lu G Gao D Lv Z Li D. The relationships between the gut microbiota and its metabolites with thyroid diseases . Front Endocrinol . 2022 Aug ; 13 : 943408 . https://doi.org/10.3389/fendo.2022.943408 Search in Google Scholar

Jung MK, Lee SY, Min EJ, Ko JM. CT Scan differences of pulmonary TB according to presence of pleural effusion. Chest. 2023 Dec; 164(6):1387–1395. https://doi.org/10.1016/j.chest.2023.06.043 Jung MK Lee SY Min EJ Ko JM. CT Scan differences of pulmonary TB according to presence of pleural effusion . Chest . 2023 Dec ; 164 ( 6 ): 1387 1395 . https://doi.org/10.1016/j.chest.2023.06.043 Search in Google Scholar

Kogut MH, Lee A, Santin E. Microbiome and pathogen interaction with the immune system. Poult Sci. 2020 Apr;99(4):1906–1913. https://doi.org/10.1016/j.psj.2019.12.011 Kogut MH Lee A Santin E. Microbiome and pathogen interaction with the immune system . Poult Sci . 2020 Apr ; 99 ( 4 ): 1906 1913 . https://doi.org/10.1016/j.psj.2019.12.011 Search in Google Scholar

Krishnan S, Ding Y, Saedi N, Choi M, Sridharan GV, Sherr DH, Yarmush ML, Alaniz RC, Jayaraman A, Lee K. Gut microbiota-derived tryptophan metabolites modulate inflammatory response in hepatocytes and macrophages. Cell Rep. 2018 Apr;23(4):1099–1111. https://doi.org/10.1016/j.celrep.2018.03.109 Krishnan S Ding Y Saedi N Choi M Sridharan GV Sherr DH Yarmush ML Alaniz RC Jayaraman A Lee K. Gut microbiota-derived tryptophan metabolites modulate inflammatory response in hepatocytes and macrophages . Cell Rep . 2018 Apr ; 23 ( 4 ): 1099 1111 . https://doi.org/10.1016/j.celrep.2018.03.109 Search in Google Scholar

Laganà AS, Garzon S, Götte M, Viganò P, Franchi M, Ghezzi F, Martin DC. The pathogenesis of endometriosis: Molecular and cell biology insights. Int J Mol Sci. 2019 Nov;20(22):5615. https://doi.org/10.3390/ijms20225615 Laganà AS Garzon S Götte M Viganò P Franchi M Ghezzi F Martin DC. The pathogenesis of endometriosis: Molecular and cell biology insights . Int J Mol Sci . 2019 Nov ; 20 ( 22 ): 5615 . https://doi.org/10.3390/ijms20225615 Search in Google Scholar

Lambrinoudaki I, Augoulea A, Creatsa M, Vlachos N, Christo-doulakos G, Papadias C. Endometriosis and other benign and malignant müllerian lesions in pelvic and extrapelvic organs. Anal Quant Cytol Histol. 2009 Jun;31(3):170–176. Lambrinoudaki I Augoulea A Creatsa M Vlachos N Christo-doulakos G Papadias C. Endometriosis and other benign and malignant müllerian lesions in pelvic and extrapelvic organs . Anal Quant Cytol Histol . 2009 Jun ; 31 ( 3 ): 170 176 . Search in Google Scholar

Lee SH, Harold D, Nyholt DR; ANZGene Consortium; International Endogene Consortium; Genetic and Environmental Risk for Alzheimer’s disease Consortium; Goddard ME, Zondervan KT, Williams J, Montgomery GW, et al. Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer’s disease, multiple sclerosis and endometriosis. Hum Mol Genet. 2013 Feb;22(4):832–841. https://doi.org/10.1093/hmg/dds491 Lee SH Harold D Nyholt DR ANZGene Consortium; International Endogene Consortium; Genetic and Environmental Risk for Alzheimer’s disease Consortium Goddard ME Zondervan KT Williams J Montgomery GW et al. Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer’s disease, multiple sclerosis and endometriosis . Hum Mol Genet . 2013 Feb ; 22 ( 4 ): 832 841 . https://doi.org/10.1093/hmg/dds491 Search in Google Scholar

Lephart ED, Naftolin F. Estrogen action and gut microbiome metabolism in dermal health. Dermatol Ther. 2022 Jul;12(7):1535–1550. https://doi.org/10.1007/s13555-022-00759-1 Lephart ED Naftolin F. Estrogen action and gut microbiome metabolism in dermal health . Dermatol Ther . 2022 Jul ; 12 ( 7 ): 1535 1550 . https://doi.org/10.1007/s13555-022-00759-1 Search in Google Scholar

Letsiou S, Peterse DP, Fassbender A, Hendriks MM, van den Broek NJ, Berger R, O DF, Vanhie A, Vodolazkaia A, Van Langen-donckt A, et al. Endometriosis is associated with aberrant metabolite profiles in plasma. Fertil Steril. 2017 Mar;107(3):699–706.e6. https://doi.org/10.1016/j.fertnstert.2016.12.032 Letsiou S Peterse DP Fassbender A Hendriks MM van den Broek NJ Berger R O DF Vanhie A Vodolazkaia A Van Langen-donckt A et al. Endometriosis is associated with aberrant metabolite profiles in plasma . Fertil Steril . 2017 Mar ; 107 ( 3 ): 699 706.e6 . https://doi.org/10.1016/j.fertnstert.2016.12.032 Search in Google Scholar

Li R, Zhou R, Wang H, Li W, Pan M, Yao X, Zhan W, Yang S, Xu L, Ding Y, et al. Gut microbiota-stimulated cathepsin K secretion mediates TLR4-dependent M2 macrophage polarization and promotes tumor metastasis in colorectal cancer. Cell Death Differ. 2019 Nov;26(11):2447–2463. https://doi.org/10.1038/s41418-019-0312-y Li R Zhou R Wang H Li W Pan M Yao X Zhan W Yang S Xu L Ding Y et al. Gut microbiota-stimulated cathepsin K secretion mediates TLR4-dependent M2 macrophage polarization and promotes tumor metastasis in colorectal cancer . Cell Death Differ . 2019 Nov ; 26 ( 11 ): 2447 2463 . https://doi.org/10.1038/s41418-019-0312-y Search in Google Scholar

Liu K, Liu X, Cao T, Cui X, Sun P, Zhang L, Wu X. Causal relationship between endometriosis and pelvic inflammatory diseases: Mendelian randomization study. Int J Womens Health. 2024 Apr;16:727–735. https://doi.org/10.2147/ijwh.s440110 Liu K Liu X Cao T Cui X Sun P Zhang L Wu X. Causal relationship between endometriosis and pelvic inflammatory diseases: Mendelian randomization study . Int J Womens Health . 2024 Apr ; 16 : 727 735 . https://doi.org/10.2147/ijwh.s440110 Search in Google Scholar

Lobo TF, Borges CM, Mattar R, Gomes CP, de Angelo AGS, Pendeloski KPT, Daher S. Impaired Treg and NK cells profile in overweight women with gestational diabetes mellitus. Am J Reprod Immunol. 2018 Mar;79(3):e12810. https://doi.org/10.1111/aji.12810 Lobo TF Borges CM Mattar R Gomes CP de Angelo AGS Pendeloski KPT Daher S. Impaired Treg and NK cells profile in overweight women with gestational diabetes mellitus . Am J Reprod Immunol . 2018 Mar ; 79 ( 3 ): e12810 . https://doi.org/10.1111/aji.12810 Search in Google Scholar

Lui JB, McGinn LS, Chen Z. Gut microbiota amplifies host-intrinsic conversion from the CD8 T cell lineage to CD4 T cells for induction of mucosal immune tolerance. Gut Microbes. 2016;7(1):40–47. https://doi.org/10.1080/19490976.2015.1117737 Lui JB McGinn LS Chen Z. Gut microbiota amplifies host-intrinsic conversion from the CD8 T cell lineage to CD4 T cells for induction of mucosal immune tolerance . Gut Microbes . 2016 ; 7 ( 1 ): 40 47 . https://doi.org/10.1080/19490976.2015.1117737 Search in Google Scholar

Magadán-Corpas P, Pérez-Valero Á, Ye S, Sordon S, Huszcza E, Popłoński J, Villar CJ, Lombó F. Gut Microbiota and inflammation modulation in a rat model for ulcerative colitis after the intraperitoneal administration of apigenin, luteolin, and xanthohumol. Int J Mol Sci. 2024 Mar;25(6):3236. https://doi.org/10.3390/ijms25063236 Magadán-Corpas P Pérez-Valero Á Ye S Sordon S Huszcza E Popłoński J Villar CJ Lombó F. Gut Microbiota and inflammation modulation in a rat model for ulcerative colitis after the intraperitoneal administration of apigenin, luteolin, and xanthohumol . Int J Mol Sci . 2024 Mar ; 25 ( 6 ): 3236 . https://doi.org/10.3390/ijms25063236 Search in Google Scholar

Maia H Jr, Haddad C, Coelho G, Casoy J. Role of inflammation and aromatase expression in the eutopic endometrium and its relationship with the development of endometriosis. Womens Health. 2012 Nov;8(6):647–658. https://doi.org/10.2217/whe.12.52 Maia H Jr Haddad C Coelho G Casoy J. Role of inflammation and aromatase expression in the eutopic endometrium and its relationship with the development of endometriosis . Womens Health . 2012 Nov ; 8 ( 6 ): 647 658 . https://doi.org/10.2217/whe.12.52 Search in Google Scholar

Ni Z, Sun S, Bi Y, Ding J, Cheng W, Yu J, Zhou L, Li M, Yu C. Correlation of fecal metabolomics and gut microbiota in mice with endometriosis. Am J Reprod Immunol. 2020 Dec;84(6):e13307. https://doi.org/10.1111/aji.13307 Ni Z Sun S Bi Y Ding J Cheng W Yu J Zhou L Li M Yu C. Correlation of fecal metabolomics and gut microbiota in mice with endometriosis . Am J Reprod Immunol . 2020 Dec ; 84 ( 6 ): e13307 . https://doi.org/10.1111/aji.13307 Search in Google Scholar

Oală IE, Mitranovici MI, Chiorean DM, Irimia T, Crişan AI, Melinte IM, Cotruş T, Tudorache V, Moraru L, Moraru R, et al. Endometriosis and the role of pro-inflammatory and anti-inflammatory cytokines in pathophysiology: A narrative review of the literature. Diagnostics. 2024 Jan;14(3):312. https://doi.org/10.3390/diagnostics14030312 Oală IE Mitranovici MI Chiorean DM Irimia T Crişan AI Melinte IM Cotruş T Tudorache V Moraru L Moraru R et al. Endometriosis and the role of pro-inflammatory and anti-inflammatory cytokines in pathophysiology: A narrative review of the literature . Diagnostics . 2024 Jan ; 14 ( 3 ): 312 . https://doi.org/10.3390/diagnostics14030312 Search in Google Scholar

Park EM, Chelvanambi M, Bhutiani N, Kroemer G, Zitvogel L, Wargo JA. Targeting the gut and tumor microbiota in cancer. Nat Med. 2022 Apr;28(4):690–703. https://doi.org/10.1038/s41591-022-01779-2 Park EM Chelvanambi M Bhutiani N Kroemer G Zitvogel L Wargo JA. Targeting the gut and tumor microbiota in cancer . Nat Med . 2022 Apr ; 28 ( 4 ): 690 703 . https://doi.org/10.1038/s41591-022-01779-2 Search in Google Scholar

Preiningerova JL, Jiraskova Zakostelska Z, Srinivasan A, Ticha V, Kovarova I, Kleinova P, Tlaskalova-Hogenova H, Kubala Havrdova E. Multiple sclerosis and microbiome. Biomolecules. 2022 Mar;12(3):433. https://doi.org/10.3390/biom12030433 Preiningerova JL Jiraskova Zakostelska Z Srinivasan A Ticha V Kovarova I Kleinova P Tlaskalova-Hogenova H Kubala Havrdova E. Multiple sclerosis and microbiome . Biomolecules . 2022 Mar ; 12 ( 3 ): 433 . https://doi.org/10.3390/biom12030433 Search in Google Scholar

R Core Team. A Language and Environment for Statistical Computing. Vienna (Austria): R Foundation for Statistical Computing; 2019 [cited 2024 May 15]. Available from https://www.r-project.org R Core Team . A Language and Environment for Statistical Computing . Vienna (Austria) : R Foundation for Statistical Computing ; 2019 [cited 2024 May 15 ]. Available from https://www.r-project.org Search in Google Scholar

Rao VA, Kurian NK, Rao KA. Cytokines, NK cells and regulatory T cell functions in normal pregnancy and reproductive failures. Am J Reprod Immunol. 2023 Feb;89(2):e13667. https://doi.org/10.1111/aji.13667 Rao VA Kurian NK Rao KA. Cytokines, NK cells and regulatory T cell functions in normal pregnancy and reproductive failures . Am J Reprod Immunol . 2023 Feb ; 89 ( 2 ): e13667 . https://doi.org/10.1111/aji.13667 Search in Google Scholar

Régnier M, Van Hul M, Knauf C, Cani PD. Gut microbiome, endocrine control of gut barrier function and metabolic diseases. J Endocrinol. 2021 Feb;248(2):R67–R82. https://doi.org/10.1530/joe-20-0473 Régnier M Van Hul M Knauf C Cani PD. Gut microbiome, endocrine control of gut barrier function and metabolic diseases . J Endocrinol . 2021 Feb ; 248 ( 2 ): R67 R82 . https://doi.org/10.1530/joe-20-0473 Search in Google Scholar

Saha R, Pettersson HJ, Svedberg P, Olovsson M, Bergqvist A, Marions L, Tornvall P, Kuja-Halkola R. Heritability of endometriosis. Fertil Steril. 2015 Oct;104(4):947–952. https://doi.org/10.1016/j.fertnstert.2015.06.035 Saha R Pettersson HJ Svedberg P Olovsson M Bergqvist A Marions L Tornvall P Kuja-Halkola R. Heritability of endometriosis . Fertil Steril . 2015 Oct ; 104 ( 4 ): 947 952 . https://doi.org/10.1016/j.fertnstert.2015.06.035 Search in Google Scholar

Sanderson E. Multivariable Mendelian randomization and mediation. Cold Spring Harb Perspect Med. 2021 Feb;11(2):a038984. https://doi.org/10.1101/cshperspect.a038984 Sanderson E. Multivariable Mendelian randomization and mediation . Cold Spring Harb Perspect Med . 2021 Feb ; 11 ( 2 ): a038984 . https://doi.org/10.1101/cshperspect.a038984 Search in Google Scholar

Sang N, Gao RC, Zhang MY, Wu ZZ, Wu ZG, Wu GC. Causal relationship between sleep traits and risk of systemic lupus erythematosus: A two-sample Mendelian randomization study. Front Immunol. 2022 Jun;13:918749. https://doi.org/10.3389/fimmu.2022.918749 Sang N Gao RC Zhang MY Wu ZZ Wu ZG Wu GC. Causal relationship between sleep traits and risk of systemic lupus erythematosus: A two-sample Mendelian randomization study . Front Immunol . 2022 Jun ; 13 : 918749 . https://doi.org/10.3389/fimmu.2022.918749 Search in Google Scholar

Sekula P, Del Greco M F, Pattaro C, Köttgen A. Mendelian randomization as an approach to assess causality using observational data. J Am Soc Nephrol. 2016 Nov;27(11):3253–3265. https://doi.org/10.1681/asn.2016010098 Sekula P Del Greco M F Pattaro C Köttgen A. Mendelian randomization as an approach to assess causality using observational data . J Am Soc Nephrol . 2016 Nov ; 27 ( 11 ): 3253 3265 . https://doi.org/10.1681/asn.2016010098 Search in Google Scholar

Shafrir AL, Farland LV, Shah DK, Harris HR, Kvaskoff M, Zondervan K, Missmer SA. Risk for and consequences of endometriosis: A critical epidemiologic review. Best Pract Res Clin Obstet Gynaecol. 2018 Aug;51:1–15. https://doi.org/10.1016/j.bpobgyn.2018.06.001 Shafrir AL Farland LV Shah DK Harris HR Kvaskoff M Zondervan K Missmer SA. Risk for and consequences of endometriosis: A critical epidemiologic review . Best Pract Res Clin Obstet Gynaecol . 2018 Aug ; 51 : 1 15 . https://doi.org/10.1016/j.bpobgyn.2018.06.001 Search in Google Scholar

Shan J, Ni Z, Cheng W, Zhou L, Zhai D, Sun S, Yu C. Gut microbiota imbalance and its correlations with hormone and inflammatory factors in patients with stage ¾ endometriosis. Arch Gynecol Obstet. 2021 Nov;304(5):1363–1373. https://doi.org/10.1007/s00404-021-06057-z Shan J Ni Z Cheng W Zhou L Zhai D Sun S Yu C. Gut microbiota imbalance and its correlations with hormone and inflammatory factors in patients with stage ¾ endometriosis . Arch Gynecol Obstet . 2021 Nov ; 304 ( 5 ): 1363 1373 . https://doi.org/10.1007/s00404-021-06057-z Search in Google Scholar

Sharifi M, Rajabpoor Nikoo N, Badehnoosh B, Shafabakhsh R, Asemi R, Reiter RJ, Asemi Z. Therapeutic effects of melatonin on endometriosis, targeting molecular pathways: Current knowledge and future perspective. Pathol Res Pract. 2023 Mar;243:154368. https://doi.org/10.1016/j.prp.2023.154368 Sharifi M Rajabpoor Nikoo N Badehnoosh B Shafabakhsh R Asemi R Reiter RJ Asemi Z. Therapeutic effects of melatonin on endometriosis, targeting molecular pathways: Current knowledge and future perspective . Pathol Res Pract . 2023 Mar ; 243 : 154368 . https://doi.org/10.1016/j.prp.2023.154368 Search in Google Scholar

Shi N, Li N, Duan X, Niu H. Interaction between the gut microbiome and mucosal immune system. Mil Med Res. 2017 Apr;4:14. https://doi.org/10.1186/s40779-017-0122-9 Shi N Li N Duan X Niu H. Interaction between the gut microbiome and mucosal immune system . Mil Med Res . 2017 Apr ; 4 : 14 . https://doi.org/10.1186/s40779-017-0122-9 Search in Google Scholar

Shin SY, Fauman EB, Petersen AK, Krumsiek J, Santos R, Huang J, Arnold M, Erte I, Forgetta V, Yang TP, et al.; Multiple Tissue Human Expression Resource (MuTHER) Consortium. An atlas of genetic influences on human blood metabolites. Nat Genet. 2014 Jun;46(6):543–550. https://doi.org/10.1038/ng.2982 Shin SY Fauman EB Petersen AK Krumsiek J Santos R Huang J Arnold M Erte I Forgetta V Yang TP et al., Multiple Tissue Human Expression Resource (MuTHER) Consortium ,. An atlas of genetic influences on human blood metabolites ,. Nat Genet . 2014 Jun ; 46 ( 6 ): 543 550 . https://doi.org/10.1038/ng.2982 Search in Google Scholar

Socała K, Doboszewska U, Szopa A, Serefko A, Włodarczyk M, Zielińska A, Poleszak E, Fichna J, Wlaź P. The role of microbiotagut-brain axis in neuropsychiatric and neurological disorders. Pharmacol Res. 2021 Oct;172:105840. https://doi.org/10.1016/j.phrs.2021.105840 Socała K Doboszewska U Szopa A Serefko A Włodarczyk M Zielińska A Poleszak E Fichna J Wlaź P. The role of microbiotagut-brain axis in neuropsychiatric and neurological disorders . Pharmacol Res . 2021 Oct ; 172 : 105840 . https://doi.org/10.1016/j.phrs.2021.105840 Search in Google Scholar

Staley JR, Blackshaw J, Kamat MA, Ellis S, Surendran P, Sun BB, Paul DS, Freitag D, Burgess S, Danesh J, et al. PhenoScanner: A database of human genotype-phenotype associations. Bioinformatics. 2016 Oct;32(20):3207–3209. https://doi.org/10.1093/bioinformatics/btw373 Staley JR Blackshaw J Kamat MA Ellis S Surendran P Sun BB Paul DS Freitag D Burgess S Danesh J et al. PhenoScanner: A database of human genotype-phenotype associations . Bioinformatics . 2016 Oct ; 32 ( 20 ): 3207 3209 . https://doi.org/10.1093/bioinformatics/btw373 Search in Google Scholar

Sun S, Xu X, Liang L, Wang X, Bai X, Zhu L, He Q, Liang H, Xin X, Wang L, et al. Lactic acid-producing probiotic Saccharo-myces cerevisiae attenuates ulcerative colitis via suppressing macrophage pyroptosis and modulating gut microbiota. Front Immunol. 2021 Nov;12:777665. https://doi.org/10.3389/fimmu.2021.777665 Sun S Xu X Liang L Wang X Bai X Zhu L He Q Liang H Xin X Wang L et al. Lactic acid-producing probiotic Saccharo-myces cerevisiae attenuates ulcerative colitis via suppressing macrophage pyroptosis and modulating gut microbiota . Front Immunol . 2021 Nov ; 12 : 777665 . https://doi.org/10.3389/fimmu.2021.777665 Search in Google Scholar

Svensson A, Brunkwall L, Roth B, Orho-Melander M, Ohlsson B. Associations between endometriosis and gut microbiota. Reprod Sci. 2021 Aug;28(8):2367–2377. https://doi.org/10.1007/s43032-021-00506-5 Svensson A Brunkwall L Roth B Orho-Melander M Ohlsson B. Associations between endometriosis and gut microbiota . Reprod Sci . 2021 Aug ; 28 ( 8 ): 2367 2377 . https://doi.org/10.1007/s43032-021-00506-5 Search in Google Scholar

Thaiss CA, Zmora N, Levy M, Elinav E. The microbiome and innate immunity. Nature. 2016 Jul;535(7610):65–74. https://doi.org/10.1038/nature18847 Thaiss CA Zmora N Levy M Elinav E. The microbiome and innate immunity . Nature . 2016 Jul ; 535 ( 7610 ): 65 74 . https://doi.org/10.1038/nature18847 Search in Google Scholar

Tong Y, Gao H, Qi Q, Liu X, Li J, Gao J, Li P, Wang Y, Du L, Wang C. High fat diet, gut microbiome and gastrointestinal cancer. Theranostics. 2021 Apr;11(12):5889–5910. https://doi.org/10.7150/thno.56157 Tong Y Gao H Qi Q Liu X Li J Gao J Li P Wang Y Du L Wang C. High fat diet, gut microbiome and gastrointestinal cancer . Theranostics . 2021 Apr ; 11 ( 12 ): 5889 5910 . https://doi.org/10.7150/thno.56157 Search in Google Scholar

van Aken M, Oosterman J, van Rijn T, Ferdek M, Ruigt G, Kozicz T, Braat D, Peeters A, Nap A. Hair cortisol and the relationship with chronic pain and quality of life in endometriosis patients. Psychoneuroendocrinology. 2018 Mar;89:216–222. https://doi.org/10.1016/j.psyneuen.2018.01.001 van Aken M Oosterman J van Rijn T Ferdek M Ruigt G Kozicz T Braat D Peeters A Nap A. Hair cortisol and the relationship with chronic pain and quality of life in endometriosis patients . Psychoneuroendocrinology . 2018 Mar ; 89 : 216 222 . https://doi.org/10.1016/j.psyneuen.2018.01.001 Search in Google Scholar

Verbanck M, Chen CY, Neale B, Do R. Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat Genet. 2018 May;50(5):693–698. https://doi.org/10.1038/s41588-018-0099-7 Verbanck M Chen CY Neale B Do R. Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases . Nat Genet . 2018 May ; 50 ( 5 ): 693 698 . https://doi.org/10.1038/s41588-018-0099-7 Search in Google Scholar

Vercellini P, Viganò P, Somigliana E, Fedele L. Endometriosis: Pathogenesis and treatment. Nat Rev Endocrinol. 2014 May;10(5): 261–275. https://doi.org/10.1038/nrendo.2013.255 Vercellini P Viganò P Somigliana E Fedele L. Endometriosis: Pathogenesis and treatment . Nat Rev Endocrinol . 2014 May ; 10 ( 5 ): 261 275 . https://doi.org/10.1038/nrendo.2013.255 Search in Google Scholar

Vicente-Muñoz S, Morcillo I, Puchades-Carrasco L, Payá V, Pellicer A, Pineda-Lucena A. Nuclear magnetic resonance metabo-lomic profiling of urine provides a noninvasive alternative to the identification of biomarkers associated with endometriosis. Fertil Steril. 2015 Nov;104(5):1202–1209. https://doi.org/10.1016/j.fertnstert.2015.07.1149 Vicente-Muñoz S Morcillo I Puchades-Carrasco L Payá V Pellicer A Pineda-Lucena A. Nuclear magnetic resonance metabo-lomic profiling of urine provides a noninvasive alternative to the identification of biomarkers associated with endometriosis . Fertil Steril . 2015 Nov ; 104 ( 5 ): 1202 1209 . https://doi.org/10.1016/j.fertnstert.2015.07.1149 Search in Google Scholar

Vouk K, Hevir N, Ribić-Pucelj M, Haarpaintner G, Scherb H, Osredkar J, Möller G, Prehn C, Rižner TL, Adamski J. Discovery of phosphatidylcholines and sphingomyelins as biomarkers for ovarian endometriosis. Hum Reprod. 2012 Oct;27(10):2955–2965. https://doi.org/10.1093/humrep/des152 Vouk K Hevir N Ribić-Pucelj M Haarpaintner G Scherb H Osredkar J Möller G Prehn C Rižner TL Adamski J. Discovery of phosphatidylcholines and sphingomyelins as biomarkers for ovarian endometriosis . Hum Reprod . 2012 Oct ; 27 ( 10 ): 2955 2965 . https://doi.org/10.1093/humrep/des152 Search in Google Scholar

Wang J, Kurilshikov A, Radjabzadeh D, Turpin W, Croitoru K, Bonder MJ, Jackson MA, Medina-Gomez C, Frost F, Homuth G, et al. Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative. Microbiome. 2018 Jun; 6(1):101. https://doi.org/10.1186/s40168-018-0479-3 Wang J Kurilshikov A Radjabzadeh D Turpin W Croitoru K Bonder MJ Jackson MA Medina-Gomez C Frost F Homuth G et al. Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative . Microbiome . 2018 Jun ; 6 ( 1 ): 101 . https://doi.org/10.1186/s40168-018-0479-3 Search in Google Scholar

Wiertsema SP, van Bergenhenegouwen J, Garssen J, Knippels LMJ. The interplay between the gut microbiome and the immune system in the context of infectious diseases throughout life and the role of nutrition in optimizing treatment strategies. Nutrients. 2021 Mar;13(3):886. https://doi.org/10.3390/nu13030886 Wiertsema SP van Bergenhenegouwen J Garssen J Knippels LMJ. The interplay between the gut microbiome and the immune system in the context of infectious diseases throughout life and the role of nutrition in optimizing treatment strategies . Nutrients . 2021 Mar ; 13 ( 3 ): 886 . https://doi.org/10.3390/nu13030886 Search in Google Scholar

Xu Q, Ni JJ, Han BX, Yan SS, Wei XT, Feng GJ, Zhang H, Zhang L, Li B, Pei YF. Causal relationship between gut microbiota and autoimmune diseases: A two-sample Mendelian randomization study. Front Immunol. 2022 Jan;12:746998. https://doi.org/10.3389/fimmu.2021.746998 Xu Q Ni JJ Han BX Yan SS Wei XT Feng GJ Zhang H Zhang L Li B Pei YF. Causal relationship between gut microbiota and autoimmune diseases: A two-sample Mendelian randomization study . Front Immunol . 2022 Jan ; 12 : 746998 . https://doi.org/10.3389/fimmu.2021.746998 Search in Google Scholar

Yang H. The causal correlation between gut microbiota abundance and pathogenesis of cervical cancer: a bidirectional mendelian randomization study. Front Microbiol. 2024 Feb;15:1336101. https://doi.org/10.3389/fmicb.2024.1336101 Yang H. The causal correlation between gut microbiota abundance and pathogenesis of cervical cancer: a bidirectional mendelian randomization study . Front Microbiol . 2024 Feb ; 15 : 1336101 . https://doi.org/10.3389/fmicb.2024.1336101 Search in Google Scholar

Zeng Y, Cao S, Yang H. Roles of gut microbiome in epilepsy risk: A Mendelian randomization study. Front Microbiol. 2023 Feb; 14:1115014. https://doi.org/10.3389/fmicb.2023.1115014 Zeng Y Cao S Yang H. Roles of gut microbiome in epilepsy risk: A Mendelian randomization study . Front Microbiol . 2023 Feb ; 14 : 1115014 . https://doi.org/10.3389/fmicb.2023.1115014 Search in Google Scholar

Zhang L, Qing P, Yang H, Wu Y, Liu Y, Luo Y. Gut microbiome and metabolites in systemic lupus erythematosus: Link, mechanisms and intervention. Front Immunol. 2021 Jul;12:686501. https://doi.org/10.3389/fimmu.2021.686501 Zhang L Qing P Yang H Wu Y Liu Y Luo Y. Gut microbiome and metabolites in systemic lupus erythematosus: Link, mechanisms and intervention . Front Immunol . 2021 Jul ; 12 : 686501 . https://doi.org/10.3389/fimmu.2021.686501 Search in Google Scholar

Zhao F, An R, Wang L, Shan J, Wang X. Specific gut microbiome and serum metabolome changes in lung cancer patients. Front Cell Infect Microbiol. 2021 Aug;11:725284. https://doi.org/10.3389/fcimb.2021.725284 Zhao F An R Wang L Shan J Wang X. Specific gut microbiome and serum metabolome changes in lung cancer patients . Front Cell Infect Microbiol . 2021 Aug ; 11 : 725284 . https://doi.org/10.3389/fcimb.2021.725284 Search in Google Scholar

Zhao H, Zhu J, Ju L, Sun L, Tse LA, Kinra S, Li Y. Osteoarthritis and stroke: A bidirectional Mendelian randomization study. Osteoarthritis Cartilage. 2022 Oct;30(10):1390–1397. https://doi.org/10.1016/j.joca.2022.06.006 Zhao H Zhu J Ju L Sun L Tse LA Kinra S Li Y. Osteoarthritis and stroke: A bidirectional Mendelian randomization study . Osteoarthritis Cartilage . 2022 Oct ; 30 ( 10 ): 1390 1397 . https://doi.org/10.1016/j.joca.2022.06.006 Search in Google Scholar

Zheng H, Liu X, Guo SW. Corroborating evidence for aberrant expression of histone deacetylase 8 in endometriosis. Reprod Med Biol. 2023 Jul;22(1):e12527. https://doi.org/10.1002/rmb2.12527 Zheng H Liu X Guo SW. Corroborating evidence for aberrant expression of histone deacetylase 8 in endometriosis . Reprod Med Biol . 2023 Jul ; 22 ( 1 ): e12527 . https://doi.org/10.1002/rmb2.12527 Search in Google Scholar

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